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University of Colorado Denver

University of Colorado Denver


Faculty Profile



Department of Anesthesiology

University of Colorado Denver


Regulation of Energy Balance

Grants: 1) R01 DK065094 “Effects of immunosuppressants on cell metabolism”

               2) NIH DK048520 (Hill) Colorado Clinical Nutrition Research Center


Description of Research

My research is often linked to my function as director of the CNRU Mass Spectrometry Core. We are constantly making an effort to develop new analytical and translational technologies and strategies including quantitative mass spectrometry assay for drugs, drug metabolites and endogenous compounds, non-targeted and targeted strategies for metabolic profiling (metabolomics) and the targeted quantification, multiplexing and non-targeted profiling of proteins (proteomics). These technologies are made available to CNRU investigators. In addition, we develop assays as requested by CNRU investigators.

My personal research interests are in the areas:

- transplantation and immunosuppression

- cholesterol-lowering drugs

- vascular endothelial dysfunction

- drug eluting stents

- pharmacokinetics and drug metabolism

- therapeutic drug monitoring

- the role of drug metabolizing enzymes and transporters in barriers (e.g. gastro-intestinal barrier and the blood-brain barrier)


1-2 Most Significant Publications

Haschke M, Zhang YL, Kahle C, Klawitter J, Korecka M, Shaw LM, Christians U. Quantification of 15-F2t-isoprostane in human urine and plasma using high-performance liquid chromatography – atmospheric pressure chemical ionization-tandem mass spectrometry. Clin Chem 2007; 53: 489-497.


Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U. Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-Coa reductase inhibitor atorvastatin. Drug Metab Dispos 28 (2000) 1369-78


Primary Focus Area (if part of the obesity initiative)

·         Obesity and metabolic dysregulation and co-morbidities


Secondary Focus Areas (if part of the obesity initiative)

·         Food intake


Access to Specialized Populations

·         none

Benefit of CNRU

The major benefit of the CNRU for me has been the enhanced interaction and collaboration with other CNRU investigators. Additionally, the CNRU allows me to interact with junior investigators through the pilot project program and through the core laboratories.  The core laboratories of the CNRU are critical to my research success.  These laboratories provide with services and expertise that are beyond the capabilities of my own research group/ laboratory. 


CNRU Cores Used

Mass Spectrometry, Metabolic Core


CNRU Collaborations

Adochio, Bergman, Bessesen, Colgan, Cornier, Eltzschig, Freed, Friedman, Ginde, Gozansky, Hansen, Higgins, Hill, Horton, Jackman, Jonscher, Klawitter, Kohrt, Krebs, Nadeau, Sundara

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