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Clinical Trials

Volunteer to Be Part of a Research Study

Page through all School of Medicine clinical and research trials below. There are two categories:

  • Detailed Trial Descriptions, submitted by researchers, includes trial specifics and contact information.

  • Additional Clinical Trials, which include basic study details. To contact the researcher either Google the PI (primary investigator) name or use our campus directory.

If you are a researcher seeking volunteers and your study is not posted, please
submit your Web ad here.

Detailed Trial Descriptions

 Results From Research and Clinical Trials : Selected site
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COMIRB Approved Advertisement TitleStudy GoalsEligibility CriteriaDate PostedCategory
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We are looking for Healthy Women to participate in a research study on.....Females, Aging, Metabolism, and Exercise (FAME)
To examine the role that female sex hormones play in metabolism, energy expenditure, physical activity and chronic disease.
Healthy women 40-60 who have regular menstrual cycles and using no hormonal contraceptives
Do you have Diabetes?
To find the best combination drug treatment for type 2 diabetes
Persons who have had diabetes for less than 5 years and metformin is the only diabetes medication you are taking.
Type 1 Diabetes Research Study
To study the effects of an FDA-approved medication on metabolism and blood vessel function.
Person 25-50 with type 1 diabetes who exercise vigorously less than four times per week and have normal blood pressure
Just received VARIVAX, the chickenpox vaccine?
Research study looking at the immune response to chickenpox vaccine
Age 12 months to 50 years; able to enroll in study within 10 days of vaccination.
Looking for HIV-positive individuals to participate in a research study on Lipodystrophy Syndrome
We are conducting a study of the relationship of bacteria in the gut to HIV infection. We are interested in finding out whether people who have metabolic diseases such as lipodystrophy (loss of fat tissue) as complications of long term antiretroviral therapy have a different makeup of their gut bacteria. We are therefore seeking volunteers with HIV infection to participate in a study of bacteria in the stool.
-Non-obese HIV positive individuals who are 18-65 years old -Either not currently on antiretroviral therapy (ART naïve or off therapy for 6 months or greater) or on effective ART with documented suppression for 6 months or greater. -We are particularly interested in enrolling subjects with lipodystrophy, but would also like to enroll individuals without lipodystrophy as controls.
Looking for HIV-positive and HIV-negative men to participate in a research study on smoking and lung disease
We are conducting a study to look at lung complications and disease in HIV/AIDS.
-Between 30 and 70 years old -Both HIV-positive and HIV-negative individuals with and without chronic obstructive pulmonary disease (COPD) -If HIV-positive, on a stable three-drug ART regimen with undetectable viral load for past 6 months
The GENETIC-AF is a trial that will investigate the safety and effectiveness of an investigational drug on the recurrence of symptomatic atrial fibrillation in people who have heart failure. The investigational drug will be studied versus an approved drug after patients receive an electrical cardioversion.
Adults who have symptomatic atrial fibrillation may be eligible.
6/28/2017Heart and Blood Diseases
Information for patients. Living with diabetes is complicated.
The FREEDOM-3S Study is a clinical research study that will involve approximately 126 patients in the United States. It will look at a potential new treatment option, the ITCA 650,for people with type 2 diabetes. The ITCA 650 is a small metal cylinder (about the size of a matchstick) that is placed under the skin of the abdomen (belly) to slowly release the study medication – exenatide. The FREEDOM-3S Study is looking at how safe and well tolerated two different doses of the ITCA 650 are in people with type 2 diabetes who are already taking liraglutide (also known as Victoza injections, and metformin.
You may be eligible to take part if you: • are 18–80 years of age • have been diagnosed with type 2 diabetes for at least 3 months • have been taking liraglutide (Victoza) injections and metformin every day for at least 3 months.
6/28/2017Gland and Hormone Related Diseases
Controlling blood glucose levels. Can be a real balancing act.
The EASE-3 clinical research study is a study in which doctors hope to learn: • Whether the investigational medicine is safe to use in treating type 1 diabetes. • Whether adding the investigational medicine is more effective in controlling blood glucose than insulin alone.
You may be able to join this study if you: • Are 18 years of age or older and you have had insulin-dependent type 1 diabetes for at least a year. • Are willing to take a study medicine in addition to your insulin therapy. • Have an HbA1c level that falls within the range required by the study. • Have a good understanding of your disease and the ability to manage it and are willing to undergo study assessments.
6/28/2017Gland and Hormone Related Diseases
Do you have headaches?
The University of Colorado is participating in a research study to determine if thoracic spine thrust manipulation alone is beneficial in the treatment of cervicogenic headaches. This project will see if this treatment can aid in reducing pain from these headaches.
You may be eligible to participate in this study if you answer yes to the following questions: - Do you have headaches that are mostly on one side which are associated with neck pain? - Are these headaches worse with movement or certain neck positions? - Do you have these headaches at least once a week for at least the last 2 months? - Are you between 18-60 years of age? - Can you come to physical therapy up to 6 times within a 30 day period? You may be ineligible to participate in this study if you have: - Rheumatoid arthritis - Osteoporosis - Broken bones in your neck or shoulder - A prolonged history of steroid use - A history of whiplash injury within the past six weeks
6/28/2017Muscle, Bone, and Cartilage Diseases
Rotator Cuff Clinical Research Study
The InSpace device is a balloon shaped implant made from a polymer, which is widely used material in the medical industry. The material is biodegradable meaning that following surgery it will gradually dissolve until it is completely absorbed at approximately one year following the implantation. During this time, the device is intended to support your shoulder healing allowing frictionless gliding between the shoulder bones which may improve shoulder muscle activity.
In order to participate, you must: Be 40 years of age or over and in general good health. Experiencing persisting shoulder pain for at least four (4) months which failed non-operative treatments such as: • Physical therapy • Activity modification • Rest (sling) • Anti-inflammatory medication Have had an MRI within 9 months that confirms a full thickness rotator cuff tear. Fulfill all study criteria as assessed by your surgeon and be willing to return for all follow-up visits.
6/28/2017--Select a Category--
Participants needed for an RSV Vaccine Study
We are looking for participants for a research study to test a vaccine to prevent Respiratory Syncytial Virus (RSV) in infants and children. Your child can participate if he/she has a healthy immune system and has never had an infection or illness caused by RSV.
- 6 months to 24 months of age -not in daycare with other children 6 months or younger
6/28/2017Viral Diseases
This study will study the effects of testosterone therapy on behavior, mood, problem solving, attention span, and motor skills in adolescent males with Klinefelter syndrome in early puberty. During this period in early puberty there is a lot of variability in how and when doctors start testosterone therapy. This study will evaluate if there are benefits to starting testosterone therapy in early puberty.
Participants with Klinefelter syndrome in early puberty (around age 10-15).
Volunteers with Alzheimer’s Disease Needed for Memory Study
To examine the safety and efficacy of the study drug, Sargramostim (Leukine®), on memory in adults with Mild-to-Moderate Alzheimer’s Disease.
1. Age 55 to 85 years; 2. Should have a mild-to-moderate Alzheimer's Disease diagnosis (Mini-Mental State Examination 10-26 inclusive); 3. If on anti-dementia treatment should be on stable treatment for at least 2 months (i.e. cholinesterase inhibitor and/or Memantine or Axona); 4. Stable on all other medications for at least 30 days prior to screen; 5. Should be fluent in English; 6. Should be physically able to participate by medical history, clinical exam and tests; 7. Should have a study partner to accompany them to scheduled visits.
T•A•C•I•T - Therapy After Cochlear Implants Using Telemedicine
This research plans to learn more about the use of telemedicine as a means of providing therapy to children who have a cochlear implant(s). While Auditory-Verbal Therapy has typically been delivered in person, many people are starting to access therapy over the internet. We are conducting this research to determine if the outcomes of therapy are the same when AVT is delivered in person and via telemedicine.
The TA•C•I•T team is looking for children ages 6 mos.-6 yrs. old who were implanted with cochlear implant(s) before age  3 ½..  Each child will spend nine months in both the in-person and telemedicine condition. The therapist will remain the same throughout the study. Total participation will last 18 months. The child will be tested three times: once when the study starts, and every nine months after that. A qualified study team member will administer speech, listening, and language tests to the child. They will also receive tests to identify how well their auditory area of the brain is developing.
Participants with Chronic Kidney Disease Needed for a Research Study about Phosphate
We are looking for men and women to participate in a research study examining whether lowering blood levels of phosphate will improve blood vessel function.
We need men and women who:  -are age 40-79 years old; women must be post-menopausal;  -have chronic kidney disease stage 3b or 4 (estimated GFR 15-45 ml/min);  -are not taking phosphate binders;  -do not have high blood phosphate (>5.5 mg/dL).
Volunteers Needed for Cardiovascular Research Study at the Division of Renal Diseases and Hypertension Clinical Research Unit
This research study will compare blood vessel function in healthy adults to adults with two different types of kidney disease. The testing visit will include non-invasive testing of blood vessel function and collection of blood and cells from an IV.  As a volunteer, you will receive the following information about your health: resting EKG; blood cholesterol screening,    blood sugar screening, blood pressure screening, and physical Exam.
We are looking for men and women, aged 50-80 years, non-smokers, generally healthy, and free from hypertension.  Women must not be pregnant of trying to become pregnant
6/27/2017--Select a Category--
Healthy Women Needed
This study plans to research how metabolic challenges of increased insulin and increased fats affect reproductive hormones.
In order to be eligible you must: Be a healthy woman age 18-38, have a BMI between 18 and 25, have regular menstrual cycles (25-35 days), not be currently using hormones (like birth control medication), not be pregnant or planning to become pregnant. In order to enroll all participants must meet specific criteria. The criteria listed above is only a partial list of all the requirements. Only a clinical research staff member can determine eligibility.
6/27/2017--Select a Category--
Does outpatient palliative care improve patient-centered outcomes in Parkinson's disease?
This study plans to learn more about the effect of palliative care on patients and caregivers affected by Parkinson’s disease or related disorders including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), multiple system atrophy (MSA) or Lewy Body Dementia (LBD). Palliative care is a treatment approach focused on improving quality of life by relieving suffering in the areas of physical symptoms such as pain, psychiatric symptoms such as depression, psychosocial issues and spiritual needs.
Over the age of 40 and have been diagnosed with Parkinson's disease (PD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), multiple system atrophy (MSA), or Lewy Body Dementia (LBD); and have unmet needs, such as poorly controlled non-motor symptoms, psychological issues, spiritual challenges or caregiver distress.
6/27/2017Nervous System Diseases
Volunteers Needed for a Research Study about Rheumatoid Arthritis
The purpose of this study is to learn more about how rheumatoid arthritis develops even before the first joint symptoms appear.
You may be able to participate in the study if: You are at least 18 years old You do NOT have rheumatoid arthritis (RA)
6/27/2017Immune System Diseases
Heart Sounds at Home: Prospective Maternal Surveillance of SSA Positive Pregnancies using a Hand-held Fetal Heart Rate Monitor
The purpose of the research study is for pregnant SSA positive mothers, using a home Doppler fetal heart rate monitor, to detect abnormal heart rates and rhythms in their babies before they are both
Exclusion criteria are: 1. If you are less than 16 weeks or > 18 6/7 th weeks pregnant 2. If you do not have SSA antibodies
6/27/2017Diseases and Abnormalities at or before Birth
Smokers Wanted for Brain Research Study
We want to know if magnetic stimulation of the brain can reduce cigarette cravings. We will do an MRI of your brain before and after the magnetic stimulation. This study takes 3 hours of your time in one single visit. We want to know if transcranial magnetic stimulation of the brain can reduce cigarette cravings. We will do an MRI of your brain before and after the magnetic stimulation. This study takes 3 hours of your time in one single visit. This study is funded by the NIH (F32 DA 041011).
You may qualify if you: • Smoke at least 10 cigarettes per day (on average) • Are 18-55 years old • Have no metal implants • Have no history of seizures • Are able to not smoke for 3 hours
6/27/2017Behaviors and Mental Disorders
Are you interested in learning about how your breast milk helps your baby grow?
To find out how maternal size and diabetes status affect her breast milk To find out what unique parts of breast milk may affect how infants grow. To learn how to ensure infants receive the best nutrition possible
Women 20-35 with type 1, type 2,or gestational diabetes who are at least 28 weeks into their pregnancy and planning on exclusively breastfeeding their infant for at least 4 months and delivering at University of Colorado Hospital.
Free Family Therapy for Youth with Mood Problems
Helping youth and their families understand and cope with mood swings, develop plans for preventing moods from getting worse, communicate more effectively and solve family problems
  • Youth between 9-17 who has recently had significant mood swings, has at least one parent with bipolar disorder and does not abuse alcohol or substances. 
  • Must agree not to participate in family therapy with another provider for the first year.
Genital Herpes?
This study will look at the body's immune response (how the body fights infection) to the onset of genital herpes.  1-2 study visits for blood draws over the course of 3 months.
  • 18+ years of age
  • Have developed an outbreak of genital herpes within the last 10 days.
Healthy Males needed for a research study of drug levels in blood and hair.
This study plans to learn more about how tenofovir and emtricitabine (Truvada) build up in cells in blood and hair. Participation will include two 12 week dosing periods separated by a 12 week washout period (total duration is 36 weeks). Eligible participants will be given the supply of medications for the study.
  • Must be age 18 to 50 years
  • Must own smartphone
  • Subject has a minimum scalp hair length of 2 cm in the occipital region.
  • Have a low risk for HIV-1 infection
The Role of Gut Bacteria in the Development of Type 1 Diabetes.
The goal of the research is to better understand the role bacteria that live in the intestine in the development of type 1 diabetes
  • Patients diagnosed with type 1 diabetes in the last 6 months 
  • Subjects with islet autoantibodies 
  • Subjects who do not have islet antibodies and are first-degree relatives of patients with diabetes or subjects with islet antibodies
  • 1-45 years of age
Are you interested in participating in a research study to help us learn more about where the fat tissue in your body originates?
To understand if some fat cells (adipocytes) may originally come from cells in the bone marrow. Understanding the origin of fat cells is important because it may help to determine the health of fat cells and why fat that is stored in some places of your body is more ‘unhealthy’ than other fat.
Men and women: Between the ages of 18 and 75 years AND Had an allogeneic hematopoietic stem cell transplant at least 6 months ago –OR– Have chronic phase chronic myeloid leukemia.
6/26/2017Nutritional and Metabolic Diseases
Are you looking for an alternative treatment for your insomnia?
The purpose of this pilot study is to learn more about treatments for insomnia. Long-term use and dependence on controlled substance sleep medications (also known as “hypnotics”) is a common issue and is a less than ideal way to treat insomnia. Stopping the use of sleeping pills and trying other treatments for insomnia is difficult for many insomnia patients. Treatments combining supervised medication tapering (SMT), which is a gradual reduction of medication use, and cognitive behavioral insomnia therapy for insomnia (CBT-I), which is a form of talk therapy that helps a person learn to better handle behaviors, habits and thoughts that lead to sleeping problems., help some who wish to stop using sleep aids, but many individuals who complete these treatments do not give up their sleep aids altogether. This project will look at how to best help insomnia patients transitioning from using sleep aids to other treatment options for their insomnia.
• Adults 21 years of age and older who have chronic insomnia • Current medication use for treatment of chronic insomnia (over one year) • Desire to stop medication use
6/26/2017Behaviors and Mental Disorders
Participants needed for a study with Diabetes and couples health behaviors
This is a couples-based approach for increasing physical activity among adults with type 2 diabetes. Increasing physical activity has been shown to have great health benefits for managing diabetes.
One partner (or both) has Type 2 Diabetes One partner (or both) has been sedentary Each member is willing to increase their current level of physical activity Between the ages of 30 and 69
6/26/2017Nutritional and Metabolic Diseases

Contact Us

Brenda Crawford, Research Coordinator, (303) 724-5362

Building 500 - 13001 E. 17th Place, Campus Box C290, Aurora, CO 80045

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