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Clinical Trials

Volunteer to Be Part of a Research Study

Page through all School of Medicine clinical and research trials below. There are two categories:

  • Detailed Trial Descriptions, submitted by researchers, includes trial specifics and contact information.

  • Additional Clinical Trials, which include basic study details. To contact the researcher either Google the PI (primary investigator) name or use our campus directory.

If you are a researcher seeking volunteers and your study is not posted, please
submit your Web ad here.
  

Detailed Trial Descriptions

 Results From Research and Clinical Trials : Selected site
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COMIRB Approved Advertisement TitleStudy GoalsEligibility CriteriaDate PostedCategory
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We are looking for Healthy Women to participate in a research study on.....Females, Aging, Metabolism, and Exercise (FAME)
To examine the role that female sex hormones play in metabolism, energy expenditure, physical activity and chronic disease.
Healthy women 40-60 who have regular menstrual cycles and using no hormonal contraceptives
5/4/2016 
Do you have Diabetes?
To find the best combination drug treatment for type 2 diabetes
Persons who have had diabetes for less than 5 years and metformin is the only diabetes medication you are taking.
5/4/2016 
Type 1 Diabetes Research Study
To study the effects of an FDA-approved medication on metabolism and blood vessel function.
Person 25-50 with type 1 diabetes who exercise vigorously less than four times per week and have normal blood pressure
5/4/2016 
CHILDHOOD and ADOLESCENT MIGRAINE PREVENTION STUDY
to test two medicines for migraine prevention in children and teens. We want to see if amitriptyline and/or topiramate are better than placebo (sugar pill) in reducing headache frequency.
Children 8-17 who have migraine headaches
5/4/2016 
Just received VARIVAX, the chickenpox vaccine?
Research study looking at the immune response to chickenpox vaccine
Age 12 months to 50 years; able to enroll in study within 10 days of vaccination.
5/4/2016 
Healthy Hispanic Female Needed
For brain imaging research study on how the brain works with we taste sweets. Your participation could help us to develop treatments and preventive measures for anorexia nervosa and obesity
Healthy females 22 to 29 who are right-handed, free of medication with no serious medical conditions, permanent metal implants or braces/retainers, and are at a healthy body weight.
5/4/2016 
Looking for HIV-positive individuals to participate in a research study on Lipodystrophy Syndrome
We are conducting a study of the relationship of bacteria in the gut to HIV infection. We are interested in finding out whether people who have metabolic diseases such as lipodystrophy (loss of fat tissue) as complications of long term antiretroviral therapy have a different makeup of their gut bacteria. We are therefore seeking volunteers with HIV infection to participate in a study of bacteria in the stool.
-Non-obese HIV positive individuals who are 18-65 years old -Either not currently on antiretroviral therapy (ART naïve or off therapy for 6 months or greater) or on effective ART with documented suppression for 6 months or greater. -We are particularly interested in enrolling subjects with lipodystrophy, but would also like to enroll individuals without lipodystrophy as controls.
5/4/2016 
Looking for HIV-positive and HIV-negative men to participate in a research study on smoking and lung disease
We are conducting a study to look at lung complications and disease in HIV/AIDS.
-Between 30 and 70 years old -Both HIV-positive and HIV-negative individuals with and without chronic obstructive pulmonary disease (COPD) -If HIV-positive, on a stable three-drug ART regimen with undetectable viral load for past 6 months
5/4/2016 
GENETIC-AF
The GENETIC-AF is a trial that will investigate the safety and effectiveness of an investigational drug on the recurrence of symptomatic atrial fibrillation in people who have heart failure. The investigational drug will be studied versus an approved drug after patients receive an electrical cardioversion.
Adults who have symptomatic atrial fibrillation may be eligible.
5/4/2016Heart and Blood Diseases
Healthy Volunteers Needed
To examine the differences in two subtypes of Parkinson Disease compared to health controls. This study involves an MRI.
- Between the ages of 50-80 - No metal in your body - In general good health
5/4/2016Nervous System Diseases
WISH - Women, insulin and sex hormones. Premenopausal women with type 1 diabetes needed for a research study.
This study plans to learn more about the menstrual cycle in women with Type 1 diabetes compared to the women who do not have diabetes. In addition, this research study plans to learn about the relationship between reproductive hormone levels and early signs of heart disease and hardening of the arteries in women with Type 1diabetes.
Age 18-45 Premenopausal Not using hormonal birth control and planning to stay off of them for at least 3 months. No currently pregnant or planning to become pregnant in the next 3 months. No recent history of amenorrhea (no menstrual period for at least 3 months) during the last 6 months. Menstrual cycle between 25-35 days on average. Normal thyroid function (can be treated) Normal kidney function (urinary albumin excretion rate
5/4/2016Heart and Blood Diseases
Healthy Volunteers Needed: Thinking and Memory in Parkinson's
This research study plans to better understand how changes in brain activity may be related to thinking problems in Parkinson's disease and to determine if stimulating certain areas the brain improves thinking and memory.
Healthy males over 50 with Parkinson's disease on stable doses of medication and have no metal in the body (dental work may be ok).
5/3/2016 
EFFECTS OF TESTOSTERONE THERAPY IN YOUNG ADOLESCENTS WITH KLINEFELTER SNDROME (47.XXY)
This study will study the effects of testosterone therapy on behavior, mood, problem solving, attention span, and motor skills in adolescent males with Klinefelter syndrome in early puberty. During this period in early puberty there is a lot of variability in how and when doctors start testosterone therapy. This study will evaluate if there are benefits to starting testosterone therapy in early puberty.
Participants with Klinefelter syndrome in early puberty (around age 10-15).
5/3/2016 
Volunteers with Alzheimer’s Disease Needed for Memory Study
To examine the safety and efficacy of the study drug, Sargramostim (Leukine®), on memory in adults with Mild-to-Moderate Alzheimer’s Disease.
1. Age 55 to 85 years; 2. Should have a mild-to-moderate Alzheimer's Disease diagnosis (Mini-Mental State Examination 10-26 inclusive); 3. If on anti-dementia treatment should be on stable treatment for at least 2 months (i.e. cholinesterase inhibitor and/or Memantine or Axona); 4. Stable on all other medications for at least 30 days prior to screen; 5. Should be fluent in English; 6. Should be physically able to participate by medical history, clinical exam and tests; 7. Should have a study partner to accompany them to scheduled visits.
5/3/2016 
T•A•C•I•T - Therapy After Cochlear Implants Using Telemedicine
This research plans to learn more about the use of telemedicine as a means of providing therapy to children who have a cochlear implant(s). While Auditory-Verbal Therapy has typically been delivered in person, many people are starting to access therapy over the internet. We are conducting this research to determine if the outcomes of therapy are the same when AVT is delivered in person and via telemedicine.
The TA•C•I•T team is looking for children ages 6 mos.-6 yrs. old who were implanted with cochlear implant(s) before age  3 ½..  Each child will spend nine months in both the in-person and telemedicine condition. The therapist will remain the same throughout the study. Total participation will last 18 months. The child will be tested three times: once when the study starts, and every nine months after that. A qualified study team member will administer speech, listening, and language tests to the child. They will also receive tests to identify how well their auditory area of the brain is developing.
5/3/2016 
Participants with Chronic Kidney Disease Needed for a Research Study about Phosphate
We are looking for men and women to participate in a research study examining whether lowering blood levels of phosphate will improve blood vessel function.
We need men and women who:  -are age 40-79 years old; women must be post-menopausal;  -have chronic kidney disease stage 3b or 4 (estimated GFR 15-45 ml/min);  -are not taking phosphate binders;  -do not have high blood phosphate (>5.5 mg/dL).
5/3/2016 
ESS-NSPAS Study
Bayer HealthCare is sponsoring a medical research study to look at the effectiveness of Essure after having a procedure (NovaSure) that decreases your heavy menstrual bleeding. Both Essure and NovaSure are approved by the FDA. This study is enrolling patients now and you may qualify to participate.
Are you currently using the Essure method of contraception? Are your periods heavy, frequent or prolonged? One important prerequisite is - you must have had a successful Essure placement AND be willing to undergo a NovaSure endometrial ablation, a treatment option for heavy menstrual bleeding (menorrhagia).
5/3/2016 
Volunteers Needed for Cardiovascular Research Study at the Division of Renal Diseases and Hypertension Clinical Research Unit
This research study will compare blood vessel function in healthy adults to adults with two different types of kidney disease. The testing visit will include non-invasive testing of blood vessel function and collection of blood and cells from an IV. As a volunteer, you will receive the following information about your health:resting EKG; blood cholesterol screening, blood sugar screening, blood pressure screening, and physical Exam.
We are looking for men and women, aged 18-80 years, non-smokers, generally healthy, and free from hypertension. Women must not be pregnant of trying to become pregnant
5/3/2016--Select a Category--
Volunteers are Invited for a Research Study Looking at Pain in Knee Osteoarthritis
- To better understand the complex experience of pain for people with knee osteoarthritis - This study will measure different aspects of pain perception and knee function in people with and without knee osteoarthritis
- Age 50-85 - NOT diagnosed with knee osteoarthritis - NO knee pain
5/3/2016Muscle, Bone, and Cartilage Diseases
Do you have insomnia or Use cannabis to help you sleep?
We are interested in learning more about the effects of cannabis use for insomnia and how it may or may not affect your sleep
Adults 21-80 years old cannabis use for sleep
5/3/2016--Select a Category--
Are you 16-45 years old and interested in participating in a research study?
We are looking for healthy individuals to serve as healthy controls to learn about children and young adults with stroke.
We need control subjects who are: -16-45 years old (currently we are seeking subjects aged 16-23 and 39-45 years old) -Non-smoker -Without history of neurological trauma or disease -Willing to undergo brain MRI scan Participation will require one visit to the Brain Imaging Center on the Anschutz Medical Campus, which will take about one hour. If requested, we can give you a free DVD copy of your MRI scan. For more information, please contact Amanda Kenny (Amanda.Kenny@ucdenver.edu; 303-724-2677).
5/3/2016Nervous System Diseases
Are you interested in learning about how your breast milk helps your baby grow?
To find out how maternal size and diabetes status affect her breast milk To find out what unique parts of breast milk may affect how infants grow. To learn how to ensure infants receive the best nutrition possible
Women 20-35 who are at least 28 weeks into their pregnancy and planning on exclusively breastfeeding their infant for at least 4 months and delivering at University of Colorado Hospital.
5/2/2016 
Free Family Therapy for Youth with Mood Problems
Helping youth and their families understand and cope with mood swings, develop plans for preventing moods from getting worse, communicate more effectively and solve family problems
  • Youth between 9-17 who has recently had significant mood swings, has at least one parent with bipolar disorder and does not abuse alcohol or substances. 
  • Must agree not to participate in family therapy with another provider for the first year.
5/2/2016 
Genital Herpes?
This study will look at the body's immune response (how the body fights infection) to the onset of genital herpes.  1-2 study visits for blood draws over the course of 3 months.
  • 18+ years of age
  • Have developed an outbreak of genital herpes within the last 10 days.
5/2/2016 
Healthy Males needed for a research study of drug levels in blood and hair.
This study plans to learn more about how tenofovir and emtricitabine (Truvada) build up in cells in blood and hair. Participation will include two 12 week dosing periods separated by a 12 week washout period (total duration is 36 weeks). Eligible participants will be given the supply of medications for the study.
  • Must be age 18 to 50 years
  • Must own smartphone
  • Subject has a minimum scalp hair length of 2 cm in the occipital region.
  • Have a low risk for HIV-1 infection
5/2/2016 
The Role of Gut Bacteria in the Development of Type 1 Diabetes.
The goal of the research is to better understand the role bacteria that live in the intestine in the development of type 1 diabetes
  • Patients diagnosed with type 1 diabetes in the last 6 months 
  • Subjects with islet autoantibodies 
  • Subjects who do not have islet antibodies and are first-degree relatives of patients with diabetes or subjects with islet antibodies
  • 1-45 years of age
5/2/2016 
Are you interested in participating in a research study to help us learn more about where the fat tissue in your body originates?
To understand if some fat cells (adipocytes) may originally come from cells in the bone marrow. Understanding the origin of fat cells is important because it may help to determine the health of fat cells and why fat that is stored in some places of your body is more ‘unhealthy’ than other fat.
Men and women: Between the ages of 18 and 75 years AND Had an allogeneic hematopoietic stem cell transplant at least 6 months ago –OR– Have chronic phase chronic myeloid leukemia.
5/2/2016Nutritional and Metabolic Diseases
Are you interested in learning more about daily blood sugar changes in your child?
The Endocrinology department at Children’s Hospital Colorado is looking for children and young adults interested in learning about day-to-day blood sugar changes. The study involves a single visit where diabetes screening will be provided as well as placement of a continuous sugar monitor to be worn for up to 7 days.
Age 10-25 years BMI < 85%ile Baseline health
5/2/2016Nutritional and Metabolic Diseases
Are you looking for an alternative treatment for your insomnia?
The purpose of this pilot study is to learn more about treatments for insomnia. Long-term use and dependence on controlled substance sleep medications (also known as “hypnotics”) is a common issue and is a less than ideal way to treat insomnia. Stopping the use of sleeping pills and trying other treatments for insomnia is difficult for many insomnia patients. Treatments combining supervised medication tapering (SMT), which is a gradual reduction of medication use, and cognitive behavioral insomnia therapy for insomnia (CBT-I), which is a form of talk therapy that helps a person learn to better handle behaviors, habits and thoughts that lead to sleeping problems., help some who wish to stop using sleep aids, but many individuals who complete these treatments do not give up their sleep aids altogether. This project will look at how to best help insomnia patients transitioning from using sleep aids to other treatment options for their insomnia.
• Adults 21 years of age and older who have chronic insomnia • Current medication use for treatment of chronic insomnia (over one year) • Desire to stop medication use
5/2/2016Behaviors and Mental Disorders
Research Study Evaluating the Implementation of a Transdiagnostic Group Intervention for Children with Behavior Problems within a Pediatric Outpatient Setting
Research study designed to learn more about a 10-week group therapy program that might be helpful for children with behavior problems and their parents/legal guardians.
Inclusion criteria for child participants: - Between 8-12 years old - Have behavior problems or a behavior disorder, such as Oppositional Defiant Disorder, Conduct Disorder, Attention-Deficit/Hyperactivity Disorder, Intermittent Explosive Disorder, Disruptive Mood Dysregulation Disorder - Able to read and complete English-language questionnaires - Able to attend 10 consecutive weeks of 90-minute group therapy sessions at Children’s Hospital Colorado - Have at least one parent/legal guardian able to complete English-language questionnaires and willing to participate in parent sessions. Exclusion criteria for child participants: - Intellectual disability - Developmental disability or significant developmental delay - Current suicidal ideation, homicidal ideation and/or self-harm behaviors - Active substance use problems - Current participation in psychological treatment or participation in psychological therapy within the past year - Do not have at least one parent/legal guardian willing to participate in the study
5/2/2016Behaviors and Mental Disorders

​Additional Clinical Trails

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INSULIN RESISTANCE AND ADENOMAS OF THE COLORECTUM (IRASC)
Sedjo, Rebecca L.01-039
INTERAGENCY REGISTRY OF MECHANICALLY ASSISTED CIRCULATORY SUPPORT (INTERMACS)
Cleveland, Joseph C06-0312
A PHASE 1 TRIAL OF PF-03084014 IN PATIENTS WITH ADVANCED SOLID TUMOR MALIGNANCY AND T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA/LYMPHOBLASTIC LYMPHOMA. Sponsor Protocol No. A8641014-1004; WIRB Protocol No. 20090536
Messersmith, Wells Alton09-0166
Evaluation of Thriving After Cancer Treatment is Complete (TACTIC) Clinic
Overholser, Linda Sue09-0597
A Phase I, Multicenter, Open-Label Dose Escalation Study of LDK378, Administered Orally in Adult Patients with Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase (ALK). Sponsor Protocol CLDK378X2101. WIRB Protocol No. 20110186
Camidge, David Ross11-0221
The effects of protective stabilization on two-year follow-up patterns of pediatric dental patients
Chin, Katherine Leong11-0523
A Phase I, Open-Label Study of the Safety and Pharmacokinetics of Escalating Doses of DMOT4039A in Patients with Unresectable Pancreatic or Platinum-Resistant Ovarian Cancer. Sponsor Protocol DMO4993g. WIRB Protocol No.20111410
Weekes, Colin Dexter11-1211
A Phase 1 and Pharmacologic Study of MM-151 in Patients with Refractory Advanced Tumors. Sponsor Protocol MM-151-01-01-01/ WIRB Protocol No. 20120026
Lieu, Christopher H11-1825
A Phase 1 Pharmacokinetic and Safety Study of Pacilitaxel Injection Concentrate for Nano-Dispersion (PICN) Alone and in Combination with Carboplatin in Subjects with Advanced Solid Malignancies. Sponsor Protocol No. CLR 10 23. WIRB Protocol No. 20120626
Jimeno, Antonio12-0489
A Phase 1 Study to Evaluate the Effect of Hepatic Impairment on the Pharmacokinetics and Safety of Crizotinib in Advanced Cancer Patients. Sponsor Protocol No. A8081012. WIRB Protocol No. 20120634
O'Bryant, Cindy L12-0515
A Phase 1b Study of the Safety and Pharmacology of MPDL3280A Administered with Bevacizumab and/or Chemotherapy in Patients with Advanced Solid Tumors. Sponsor Protocol GP28328. WIRB Protocol No. 20121229
Eckhardt, Sue G12-0927
Heart Failure Symptom Clusters and Heart Failure Self-care: an exploratory descriptive study
McDermott, Carrie Martha12-1608
A Phase I, multi-center, non-randomized, open label, parallel-group study evaluating the pharmacokinetics and safety of regorafenib (BAY 73-4506) in cancer subjects with severe renal impairment compared to a control group. Sponsor Protocol No. BAY 73-4506 / 16653. WIRB Protocol No. 20130998
O'Bryant, Cindy L13-1882
A Multi-Center, Dose Finding, Open Label, Phase 1 Study of RX-5902 in Subjects with Advanced or Metastatic Solid Tumors. Sponsor Protocol No. RX-5902-P1-01. WIRB Protocol No. 20131320
Eckhardt, Sue G13-2176
A PHASE 1B OPEN-LABEL THREE-ARM MULTI-CENTER STUDY TO ASSESS THE SAFETY AND TOLERABILITY OF PF-05212384 (PI3K/mTOR INHIBITOR) IN COMBINATION WITH OTHER ANTI-TUMOR AGENTS. Sponsor Protocol No. B2151002. WIRB Protocol No. 20131499
Leong, Stephen13-2359
A Phase 1b Dose Escalation Study of Vantictumab (OMP-18R5) in Combination with Nab-Paclitaxel and Gemcitabine in Patients with Previously Untreated Stage IV Pancreatic Cancer. Sponsor Protocol No. 18R5-003. WIRB Protocol No. 20131595
Messersmith, Wells Alton13-2391
A Dose-regimen Finding Study to Evaluate Safety, Tolerability, Pharmacokinetics and Activity of Oraxol in Subjects with Advanced Malignancies. Sponsor Protocol No. ORAX-01-13-US. WIRB Protocol No. 20131698
Jimeno, Antonio13-2451
A MULTI-CENTER,OPEN LABEL, FIRST IN HUMAN, PHASE I DOSE ESCALATION STUDY TO INVESTIGATE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF RO6839921, AN MDM2 ANTAGONIST FOLLOWING INTRAVENOUS ADMINISTRATION IN PATIENTS WITH ADVANCED MALIGNANCIES, INCLUDING ACUTE MYELOID LEUKEMIA (AML). Sponsor Protocol No. NP28903. WIRB Protocol No. 20140542
Gore, Lia13-2649
A Randomized, Double-Blind, Placebo-Controlled Study of Chemotherapy Plus Cetuximab in Combination with VTX-2337 in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck. Sponsor Protocol No. VRXP-A202. WIRB Protocol No. 20131627
Jimeno, Antonio13-2911
Quantifying Surgeon Physical Discomfort Among Otolaryngologists
Terella, Adam13-3169
A Phase 1, Multicenter, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-120 in Subjects with Advanced Solid Tumors, Including Glioma, with an IDH1 Mutation Sponsor Protocol No. AG120-C-002 WIRB Protocol No. 20140544
Gore, Lia14-0012
A Phase Ib dose escalation/randomized phase II multicenter, open-label study of BYL719 in combination with cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma. Sponsor Protocol No. CBYL719X2104. WIRB Protocol No.20140692
Jimeno, Antonio14-0034
A Phase 1, Open-Label, Dose-Escalation Study Evaluating the Safety, Pharmacokinetics, and Clinical Effects of Intravenously Administered PT-112 Injection in Subjects with Advanced Solid Tumors. Sponsor Protocol No. PT-112-101. WIRB Protocol No. 20140867
Camidge, David Ross14-0151
A MULTICENTER PHASE 1A/1B ASCENDING DOSE STUDY OF DCC-2701 TO ASSESS SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS IN PATIENTS WITH ADVANCED SOLID TUMORS Sponsor Protocol No. DCC-2701-01-001 WIRB Protocol No. 20142004
Leong, Stephen14-0244
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Assessing the Effect of Gelesis100 on Body Weight in Overweight and Obese Subjects with and without Type 2 Diabetes. Sponsor Protocol No. G-04. WIRB Protocol No. 20150046
Hill, James O14-0383
A Phase Ib Open Label Study of the Safety and Tolerability of ME-344 Given in Combination with Topotecan (Hycamtin®) in Patients with Solid Tumors. Sponsor Protocol No. ME-344-002, WIRB Protocol No. 20140982
Diamond, Jennifer R14-0413
A Phase I, Dose-escalation Study of the Safety, Pharmacokinetics and Efficacy of Weekly Intravenous Briciclib in Patients with Advanced Solid Tumors Sponsor Protocol No. 08-02 WIRB Protocol No. 20141094
Jimeno, Antonio14-0565
A PHASE 1, DOSE ESCALATION STUDY OF PF-06664178 IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC SOLID TUMORS Sponsor Protocol No. B7401001 WIRB Protocol No. 20141074
Messersmith, Wells Alton14-0581
A Phase 1 Study of Oprozomib to Assess Food Effect, Drug-Drug Interaction with Midazolam, and Safety and Tolerability in Patients with Advanced Malignancies Sponsor Protocol No. OPZ009 WIRB Protocol No. 20141700
Gore, Lia14-0589
A Multicenter, Randomized, Open-Label Phase 3 Study to Investigate the Efficacy and Safety of Aldoxorubicin Compared to Investigator's Choice in Subjects with Metastatic, Locally Advanced, or Unresectable Soft Tissue Sarcomas Who Either Relapsed or Were Refractory to Prior Non-Adjuvant Chemotherapy. Sponsor Protocol No. ALDOXORUBICIN-PE-STS-01. WIRB Protocol No. 20141245
Elias, Anthony David14-1004


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