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RNA Biosceince Initiative

 

Regulatory RNAs


Regulatory RNAs

​The goals of the Regulatory RNA group are to identify and elucidate new RNA regulatory mechanisms with the goal of examining these RNAs in basic biology and disease, bringing these discoveries into the clinic whenever possible.

The Regulatory RNA Group within the RNA Bioscience Initiative is grounded in investigation of the molecular mechanisms that regulate RNA biogenesis and the mechanisms by which non-coding RNAs exert control over an ever-expanding number of cellular activities, ranging from translation to chromatin modification to genome editing. 

Faculty participatng in the Regulatory RNA group currently have primary appointments in several departments and divisions in the School of Medicine.

Additional faculty will be recruited to enhance this research area.​

Dr. Jeffrey Kieft heads the Regulatory RNA group. ​   

Affiliated faculty include

David Barton, PhDEnterovirus RNA replication

David Bentley, PhD - Messenger RNA Production by RNA polymerase II

Richard Davis, PhD - Programmed DNA elimination and RNA metabolism in parasitic helminths

Thomas Evans, PhD - RNA control of embryonic polarity

Heide Ford, PhD - RNA function in breast cancer

James Hagman, PhD - Regulation of B-lymphcyte specific differentiation

Jay Hesselberth, PhD - Genomics of gene regulation

Aaron Johnson, PhD - Mechanisms of chromatin-mediated gene silencing

Peter Kabos, PhD - Breast cancer RNA metabolism​

Jeffrey Kieft, PhD - Protein Translation and RNA structure

Sandy Martin, PhD - ​Mechanism of LINE-1 retrotransposition and differential gene expression during hibernation

Lee Niswander PhD – lncRNAs in development

Jennifer Richer, PhD - miRNAs in cancer

Linda van Dyk, PhDControl of growth regulation and differentiation of host cells in viral infection and persistence

Trevor Williams PhD - Small RNA expression during craniofacial development

Rui Zhao, PHD - Molecular mechanism of pre-mRNA splicing; drug design targeting transcriptional complex in breast cancer