The goals of the RNA and Disease group
are to identify and define the contribution of RNA to disease including viral
and other pathogens.
Errors in RNA
processing and maturation can lead to human disease. Increasingly errors in
splicing, tRNA and snoRNA maturation, and other aspects of metabolism are
identified that lead to disease. Viral and
other pathogen RNAs play key roles in infection and regulation of host
metabolism. Analyses of RNA in disease may provide new insights into the roles
of RNA in biology and new avenues for disease treatment. Faculty participating in
the RNA and Disease group currently have their primary homes in five different
departments and medical divisions of the School of Medicine.
Additional faculty will be recruited to enhance this research area.
Eric Poeschla and Linda van Dyk head the RNA and Disease group.
David Barton, PhD – Enterovirus RNA replication
Susan Boackle, MD – Systemic lupus Erythematosis
Richard Davis, PhD – RNA metabolism in parasitic helminths
Peter Kabos, MD – Breast cancer RNA metabolism
Eric Pietras PhD – RNA splicing alterations in myelodysplasia
Eric Poeschla, MD – Viral replication, host innate immunity to viruses, and viral disease pathogenesis
Mario Santiago PhD – HIV gene expression
Carol Sartorius PhD – Hormone-dependent cancers
Jennifer Richer, PhD – miRNAs in cancer
Lori Sussel, PhD – Long non-coding RNAs in diabetes
Linda van Dyk, PhD – Herpesvirus pathogenesis