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RNA and Disease

RNA Disease

The goals of the RNA and Disease group are to identify and define the contribution of RNA to disease including viral and other pathogens.

Errors in RNA processing and maturation can lead to human disease. Increasingly errors in splicing, tRNA and snoRNA maturation, and other aspects of metabolism are identified that lead to disease. Viral and other pathogen RNAs play key roles in infection and regulation of host metabolism. Analyses of RNA in disease may provide new insights into the roles of RNA in biology and new avenues for disease treatment. Faculty participating in the RNA and Disease group currently have their primary homes in five different departments and medical divisions of the School of Medicine.

Additional faculty will be recruited to enhance this research area.​

Drs. Eric Poeschla and Linda van Dyk head the RNA and Disease group.

Affiliated Faculty

David Barton, PhD  Enterovirus RNA replication

David Bentley, PhD - The coordination of transcription with chromatin modification, splicing, and mRNA 3' end formation. How mRNA production in cancer cells becomes corrupted bt abnormal coupling of these pathways

Susan Boackle, MD  Systemic lupus Erythematosis

Richard Davis, PhD  RNA metabolism in parasitic helminths

Sujatha Jagannathan, PhD - How cells detect and degrade abberant RNAs, and how dysregulation of this surveillance process contributes to muscular dystrophy

Aaron Johnson, PhD -  Molecular mechanisms of RNA-mediated epigenetic gene regulation in normal biology and metastatic breast cancer  

Peter Kabos, MD  Breast cancer RNA metabolism

Jeffrey Kieft, PhD - How RNAs form complex 3-D folds, the dynamic conformational changes they undergo, how these RNAs interact with other molecules, and how this drives diverse biological function in healthy and diseased cells. In particular, how viral RNAs manipulate host cell machinery

Traci Lyons, PhD- Mechanisms of therapeutic resistance and metastasis driven by pregnancy induced changes in gene and protein expression during mammary gland development 

Neelanjan Mukherjee, PhD - Mechanisms by which RNA binding proteins (RBPs) and long non-coding RNA (lncRNAs) regulate human steroid production. Use genomic approaches to identify the targets of RBPs or lncRNA and the layer of RNA regulation they control

Eric Pietras PhD – RNA splicing alterations in myelodysplasia

Eric Poeschla, MD  Viral replication, host innate immunity to viruses, and viral disease pathogenesis

Tania Reis, PhD - RNA and neuronal control of metabolism and obesity

Mario Santiago PhD – HIV gene expression

Carol Sartorius PhD – Hormone-dependent cancers

Jennifer Richer, PhD  miRNAs in cancer

Lori Sussel, PhD  Long non-coding RNAs in diabetes

Linda van Dyk, PhD  Herpesvirus pathogenesis