The goals of the RNA Technology and Informatics section are
to develop and improve methods to analyze RNA diversity, nascent transcription,
sequence, and structure; and to create new computational methods to support these
New RNA technologies and computational methods fuel new
discoveries to advance the field of RNA biology. Recent advances include:
- RNA analysis from complex cell populations and single cells.
methods for analysis of non-coding RNAs, nascent transcription, RNA chemical
modifications, RNA 5’ and 3’ end modification and RNA structure.
- Improved computational approaches to support large-scale RNA sequencing efforts
Several faculty searches are underway to enhance this research area and group.
Dr. Jay Hesselberth heads the RNA Technology and Bioinformatics group
David Bentley, PhD - Messenger RNA Production by RNA polymerase II
Richard Davis, PhD - Programmed DNA elimination and RNA metabolism
Jay Hesselberth, PhD - Genomics of DNA and RNA repair
Sujatha Jagannathan, PhD - How cells detect and degrade aberrant RNAs, and how dysregulation of this surveillance process contributes to muscular dystrophy
Neelanjan Mukherjee, PhD - Mechanisms by which RNA binding proteins (RBPs) and long non-coding RNA (lncRNAs) regulate human steroid production. Use genomic approaches to identify the targets of RBPs or lncRNA and the layer of RNA regulation they control
Matthew Taliaferro, PhD - Genome engineering, high-throughput sequencing, and single-molecule microscopy to study how RNA molecules are trafficked and localized to distinct subcellular locations