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RNA Technology and Bioinformatics


RNA Technology

The goals of the RNA Technology and Informatics section are to develop and improve methods to analyze RNA diversity, nascent transcription, sequence, and structure; and to create new computational methods to support these analyses.

New RNA technologies and computational methods fuel new discoveries to advance the field of RNA biology. Recent advances include:

  • RNA analysis from complex cell populations and single cells.
  • Improved methods for analysis of non-coding RNAs, nascent transcription, RNA chemical modifications, RNA 5’ and 3’ end modification and RNA structure.
  • Improved computational approaches to support large-scale RNA sequencing efforts 

Several faculty searches are underway to enhance this research area and group.

Dr. Jay Hesselberth heads the RNA Technology and Bioinformatics group

Affiliated Faculty

David Bentley, PhD - Messenger RNA Production by RNA polymerase II

Richard Davis, PhD - Programmed DNA elimination and RNA metabolism

Jay Hesselberth, PhD - Genomics of DNA and RNA repair

Sujatha Jagannathan, PhD - How cells detect and degrade aberrant RNAs, and how dysregulation of this surveillance process contributes to muscular dystrophy

Neelanjan Mukherjee, PhD - Mechanisms by which RNA binding proteins (RBPs) and long non-coding RNA (lncRNAs) regulate human steroid production. Use genomic approaches to identify the targets of RBPs or lncRNA and the layer of RNA regulation they control

Matthew Taliaferro, PhD - Genome engineering, high-throughput sequencing, and single-molecule microscopy to study how RNA molecules are trafficked and localized to distinct subcellular locations