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RNA Biosceince Initiative

 

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Foundation

The RNA Bioscience Initiative was started with a $20 million award, with major contributions from philanthropic donations. Additional donations can be made through the CU foundation.

History of RNA Research in Colorado

RNA research has a storied history in Colorado, and seminal discoveries in RNA biology were made at CU Boulder. Notable examples include:

  • Demonstration that RNA can act as a catalyst (Thomas Cech, 1989 Nobel Prize)
  • Development of in vitro selection (SELEX) to identify RNA ligands (Larry Gold)
  • Characterization of molecular biology enzymes for synthesizing and modifying RNA (Olke Uhlenback)​
  • Chemical synthesis methods for RNA (Marvin Carruthers)
  • Studies of ribosomal RNA phylogeny (Norman Pace)

These discoveries were complemented by a legendary "RNA Club" in Boulder that brought together the brightest minds in RNA biology. Today, RNA research in Colorado is thriving. Researchers in Boulder, Denver, and Fort Collins continue to make key contributions to RNA research.

Local Shared RNA Resources

Program to Understand the Longterm Outcomes in SpondyloARthritis (PULSAR)

PULSAR maintains a bank of RNA samples from about 400 subjects with HLAB27 associated conditions, including psoriasis, psoriatic arthritis, ankylosing spondylitis, and inflammatory bowel disease. The samples are tied to a very rich clinical patient database with patient reported outcomes, demographics, and other information. For more information, or to use the sample bank, contact Liron Caplan.