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Kristen Rumer

BA, Chemistry and Biochemistry (1998) University of Colorado Boulder


 

RC1 North, P18 5401K

Phone: 303-724-1653


 

Kristen.Rumer@ucdenver.edu



Placental invasion of maternal decidua is a complex and incompletely characterized process. When invasion is insufficient, as in the case of preeclampsia, both the mother and fetus can experience harm. The current model of preeclampsia is that the placenta fails to develop properly early in gestation, which leads to toxic factor secretion into the maternal system in late gestation. The latter events lead to the clinical signs of preeclampsia, including hypertension, edema and proteinuria. Toward understanding placental development, micorarray studies in the Winn lab have identified genes involved in the development of normal and preeclamptic placentas across gestation. In these studies it was found that Siglec-6 is upregulated in preeclamptic placentas near term when compared to age matched controls. Siglec-6 is a transmembrane receptor expressed in placental and B-cells whose biology is not well characterized. Siglec-6 was originally cloned as a leptin binding partner. Leptin is well known in the regulation of energy homeostasis, but overexpression has also been demonstrated in preeclampsia. I am investigating the roles of Siglec-6 and Leptin in placental development and in the pathogenesis of preeclampsia.

Rumer K., McDaniel S, Biroc S, Metz R, Singh M, Porter W, and Schedin P. Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis. Am J of Path. 2006; 168:608-620.

Galasinski SC, Louie DF, Gloor KK, Resing KA, Ahn NG. Global regulation of post-translational modifications on core histones. J Biol Chem. 2002 Jan 25; 277(4):2579-88.

Gloor KK, Louie DF, Galasinski SC, Resing KA, Ahn NG. Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry. Protein Sci. 2000 Jan;9(1):170-9.

Mansour SJ, Candia JM, Gloor KK, Ahn NG. Constitutively active MAPKK1 and MAPKK2 mediate similar transcriptional and morphological responses. Cell Growth Differ. 1996 Feb;7(2):243-50.

I spend most of my time hanging out with my daughters, husband and extended family. When I take time for myself, I run, golf, scrapbook, read or spend time with my friends.