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Dr. Maller's laboratory studies the molecular regulation of decision points in the cell cycle during which commitments are made to enter DNA synthesis and enter or exit mitosis. Checkpoint decisions are regulated by integrated signals that control the activity of protein kinases and phosphatases which regulate the phosphorylation state of key enzymes involved in cell cycle control. The overall goal is to learn how the cellular decision to proceed in the cell cycle is elaborated at these decision points. Dr. Maller is also interested in signal transduction pathways that utilize sequential phosphorylation and activation of several protein kinases, resulting in a cascade of signalling modules important for growth control and integrated cellular function.