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William W. Hay Jr., Professor

M.D. Yale University



Co-Director, Colorado Clinincal and Translational Sciences Institute
Director, Child Maternal Health Program & Director, Perinatal Clinincal Translational Research Center

Perinatal Research Center
13243 East 23rd Avenue
Aurora, CO 80045
Phone: 303-724-1600

Bill.Hay@ucdenver.edu

Research Interests:

  • Perinatal (fetal, placental, maternal) physiology
  • Mammalian Carbohydrate Metabolism
  • Perinatal Pathophysiology of Diabetes Mellitus
  • Intrauterine Growth Restriction
  • Neonatal Perinatal Medicine
  • Fetal and Neonatal Nutrition
  • Pulse Oximetry

Wallace JM, Milne JS, Aitken RP, Hay WW Jr. Sensitivity to metabolic signals in late gestation growth restricted fetuses from rapidly growing adolescent sheep. Am J Physiol Endo Metab 293: E1233-1241.
 
Limesand SW, Rozance PJ, Smith D, Hay WW Jr. Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction. Am J Physiol Endo Metab 293: E1716-1725, 2007.
 
Rozance PJ, Limesand SW, Barry JS, Brown LD, LoTurco D, Regnault TRH, Friedman JE, Hay WW Jr. Chronic late gestation hypoglycemia up-regulates hepatic PEPCK associated with Increased PGC1α mRNA and pCREB in fetal sheep. Am J Physiol Endo Metab 294: E365-370, 2007.

Rozance PJ, Limesand SW, Zerbe GO, Hay WW, Jr., Chronic fetal hypoglycemia inhibits the later steps of stimulus-secretion coupling in pancreatic β-cells. Am J Physiol Endocrinol Metab 292: E1256-E1264, 2007.
 
Manco-Johnson MM, Jacobson L, Hacker MR, Hay WW Jr. Pharmacokinetics of Protein C and Antithrombin in the fetal lamb: a model to predict human neonatal replacement dosing. Neonatology 95:279-285, 2009.
 
Rozance PJ, Limesand SW, Barry JS, Brown LD, and Hay WW Jr. Glucose replacement causes hypoxia, acidosis, and decreased insulin secretion in a sheep model of intrauterine growth restriction. Pediatr Res 65: 72-78, 2009.
 
Brown LD, Rozance PJ, Barry JS, Friedman JE, Hay WW Jr. Insulin is required for amino acid stimulation of the Akt/p70S6K signaling pathway in skeletal muscle in the late gestation ovine fetus. Am J Physiol Endocrinol Metab 296: E56-E63, 2009.
 
Limesand SW, Rozance PJ, Brown LD, and Hay WW Jr. Effects of chronic hypoglycemia and euglycemic correction on lysine metabolism in fetal sheep. Am J Physiol Endocrinol Metab 296: E879-E887, 2009.
 
Thorn SR, Regnault, TRH, Brown LD, Rozance PJ, Keng J, Roper M, Wilkening RB, Hay WW Jr., Friedman JE.
Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces hepatic and skeletal muscle mRNA translation initiation and nutrient sensing. Endocrinology 150: 3021-3030, 2009.
 

Rozance PJ, Crispo MM, Barry JS, O'Meara MC, Frost MS, Hansen KC, Hay WW Jr., Brown LD. Prolonged maternal amino acid infusion in late-gestation pregnant sheep increases fetal amino acid oxidation. <http://www.ncbi.nlm.nih.gov/pubmed/19602583>  Am J Physiol Endocrinol Metab. 297: E638-E646, 2009.

Green As, Macko AR, Yates DT, Chen X, Rozance PJ, Hay WW Jr., Limesand SW. Characterization of glucose-insulin responsiveness and impact of fetal number and gender on insulin response in the sheep fetus. Am J Physiol Endocrinol Metab. 300:E817-E823, 2011.

Chen X, Rozance PJ, Hay WW Jr., Limesand SW. Insulin-like Growth Factor and Fibroblast Growth Factor Expression Profiles in Growth Restricted Fetal Sheep Pancreas. Experimental Biology and Medicine, in press, May, 2012.

Brown LD, Rozance PJ, Thorn SR, Friedman JE, Hay WW Jr. Acute supplementation of amino acids increases net fetal protein accretion in IUGR fetal sheep. AJP Endo Metab, in press, 05/20/12. 


Latest Publications in PubMed