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Vaccine Preventable Diseases

 

In the United States, childhood immunizations of seven vaccines (DTap, Td, Hib, polio, MMR, Hepatitis B, and varicella) prevent over 14 million cases of disease over the lifetime of a child born in any given year. Significant disparities exist in vaccination delivery by age group (eg, child vs. adolescent vs. adult), race/ethnicity and socioeconomic status.

Since the inception of COR ten years ago, vaccine delivery research has been one of our strongest areas of research.  Investigators at COR (Drs. Kempe, Daley, Berman, Dickinson, Crane, O’Leary, Suh, Kelminson) have studied a variety of issues related to vaccine delivery at the level of the patient (acceptability of different vaccines, barriers to vaccination, preferences regarding location of childhood vaccination and vaccine refusal and hesitancy), the practice (financing issues, reminder/recall of patients, innovative delivery methods for different vaccines), the state (comparison of practice-based versus county-based recall methods for immunizations, evaluations of school-based immunization delivery) and nationally (primary care physicians’ practices, attitudes and beliefs regarding numerous vaccines and vaccine delivery issues). 

COR’s work in vaccine delivery research has directly affected state and national policy through our publications, through our contributions to a report of the Institute of Medicine and through numerous presentations to the immunization policy-making branch of the CDC, the Advisory Committee on Immunization Practices (ACIP).  The vaccine delivery research group has been continuously funded with multiple R01 level grants and currently has four R01 grants, one of which is an NIH Challenge grant.

 

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Current Grants

Promoting New Adolescent Vaccines: The Role of Complementary Health Care Settings
Principal Investigator: Matthew F. Daley, MD
Co-Principal Investigator: Allison Kempe, MD, MPH
COR Co-Investigators: Lori A. Crane, PhD, Miriam Dickinson, PhD, and Deborah Main, PhD
Funding Agency: National Immunization Program CDC – 5-U01-IP000110-02
Amount: $400,000
Term: 2006 - 2008

Vaccine Safety Datalink-Children
Principal Investigator: Jason Glanz, MD
TCH/COR Co-Investigator: Matthew F. Daley, MD
Funding Agency: CDC, Administered through America’s Health Insurance Plans (AHIP) - PN200200200732
Amount: $9,758,528
Term: 2002 - 2012

Evaluation of Vaccination Reminder/Recall Systems for Adolescent Patients
Principal Investigator: Allison Kempe, MD, MPH
TCH Co-Investigator: Matthew F. Daley, MD
COR Co-Investigators: Miriam Dickinson, PhD, Judith E. Glazner, MS, Christina Suh, MD and Deborah Main, PhD
Funding Agency: CDC – 1-U01-P000129-02
Amount: $595,000
Term: 2007 – 2010

Vaccine Policy Collaborative Initiative
Principal Investigator: Allison Kempe, MD, MPH
TCH Co-Investigators: Matthew F. Daley, MD, Stephen Berman, MD, and Christina A. Kim, MD, MSPH
COR Co-Investigators: Lori A. Crane, PhD, Laura Hurley, MD, MSPH, and Miriam Dickinson, PhD
Funding Agency: CDC, Cooperative with AAMC, MM - 1040-08/08
Amount: $300,000/yr
Term: 2008 – 2010

Examination of the Feasibility of Obtaining Third-Party Payer Reimbursements for Adolescent Vaccinations Delivered in a School Setting
Principal Investigator: Judith Shlay, MD
TCH/COR Co-Investigators: Matthew F. Daley, MD, and Allison Kempe, MD, MPH
Funding Agency: CDC - 1U01P00016-01
Amount: $600,000
Term: 2008 - 2010

Examination of the Feasibility of Obtaining Third-Party Payer Reimbursements for Influenza Vaccinations Delivered in a School Setting
Principal Investigator: Judith Shlay, MD
TCH/COR Co-Investigators: Allison Kempe, MD, MPH, and Matthew F. Daley, MD
Funding Agency: CDC - 1U01P000199
Amount: $600,000
Term: 2008 – 2010

Population-based versus Practice-based Interventions to Increase Immunization Rates
Principal Investigator: Allison Kempe, MD, MPH
TCH/COR Co-Investigators: Stephen Berman, MD, Miriam Dickinson, PhD
Funding Agency: NIH
Amount: $500,000/yr for 2 years
Term: 2009 – 2011

Strategies to Vaccinate all Children for Influenza in a Practice Setting
Principal Investigator: Allison Kempe, MD, MPH
TCH/COR Co-Investigators: Sean O’Leary, MD, Miriam Dickinson, PhD
Funding Agency: CDC
Amount: $260,000/yr for 3

Abstracts

Babbel C, Wallace GS, Stokley S, Daley MF, Crane LA, Black SR, Barrow J, Dickinson LM, Kempe A. Are Primary Care Physicians Following Interim Recommendations for the Use of Haemophilus Influenzae Type B (Hib) Vaccine During Shortages? Oral Presentation, 43rd National Immunization Conference, Dallas, TX, March 30-April 2, 2009.

Barrow J, Saville AW, Abrams L, Hobkirk M, Seewald L, Dong F, Barnard J, Daley MF, Kempe A. Vaccination Recall for 6th Graders Enrolled in a School-Based Health Center. Poster presentation, Colorado Public Health Association Annual Meeting, Copper Mountain, CO September 28-30, 2009.

Daley MF, Markowitz LE, Black SR, Barrow J, Babbel C, Liddon N, Gottlieb S, , Stokley S, Dickinson LM, Crane LA, Kempe A. Human Papillomavirus Vaccination Practices: A National Survey of Physicians 18 Months Post-Licensure. Oral Presentation, 43rd National Immunization Conference, Dallas, TX, March 30-April 2, 2009.

Daley MF, Markowitz LE, Crane LA, Black SR, Barrow J, Babbel C, Gottlieb S, Liddon N, Stokley S, Dickinson LM, Kempe A. Human Papillomavirus Vaccination Practices: A National Survey of Physicians 18 Months Post-Licensure. Poster symposium presentation, Pediatric Academic Societies' Annual Meeting, Baltimore, Maryland, May 2-5, 2009.

Daley MF. Safety of Trivalent Inactivated Influenza Vaccine in Children Ages 24 to 59 Months: A Vaccine Safety Datalink Study. Oral Presentation, 43rd National Immunization Conference, Dallas, TX, March 30-April 2, 2009.

Daley, MF, Curtis, CR, Pyrzanowski J, Barrow J, Benton K, Abrams L, Federico S, Juszczak L, Melinkovich P, Crane LA, Kempe A. Adolescent Immunization Delivery in School-Based Health Centers: A National Survey. Oral Presentation, 43rd National Immunization Conference, Dallas, Texas, March 30-April 2, 2009.

Hurley L, Lindley M, Harpaz R, Stokley S, Daley MF, Crane LA, Beaty B, Barrow J, Babbel C, Dickinson LM, Kempe A. Herpes Zoster Vaccine: What is Interfering with Uptake? Oral Presentation, 43rd National Immunization Conference, Dallas, TX, March 30-April 2, 2009.

Hurley L, Lindley M, Harpaz R, Stokley S, Daley MF, Crane LA, Beaty B, Barrow J, Babbel C, Dickinson LM, Kempe A. Herpes Zoster Vaccine: What is Interfering with Uptake? Oral Presentation, 32nd Annual Society of General Internal Medicine Conference, Miami, Florida, May 13-16, 2009.

Kempe A, Babbel C, Wallace GS, Stokley S, Daley MF, Crane LA, Black SR, Barrow J, Dickinson LM. Are Primary Care Physicians Following Interim Recommendations for the Use of Haemophilus Influenzae Type B (Hib) Vaccine During Shortages? Poster presentation, Pediatric Academic Societies' Annual Meeting, Baltimore, Maryland, May 2-5, 2009.

Pyrzanowski J, Curtis CR, Crane LA, Barrow J, Beaty B, Kempe A, Daley MF. Adolescents’ Perspectives on Vaccination outside the Traditional Medical Home: a Survey of Urban Middle and High School Students. Poster symposium presentation, Pediatric Academic Societies' Annual Meeting, Baltimore, Maryland, May 2-5, 2009.

Saville AW, Nowels C, Barnard J, Daley MF, Kempe A. Barriers to and recommendations for implementing immunization reminder/recall among adolescent patients in private pediatric practices. Oral presentation, Colorado Public Health Association Annual Meeting, Copper Mountain, CO September 28-30, 2009.

Suh CA, Daley MF, Huang W, Crane LA, Babbel C, Barrow J, Marin M, Stokley S, Broder K, Beaty B, Kempe A. Febrile Seizures and Measles, Mumps, Rubella, and Varicella Virus Vaccine (MMRV): A National Survey of Physicians. Oral Presentation, 43rd National Immunization Conference, Dallas, TX, March 30-April 2, 2009.

Suh CA, Daley MF, Huang W, Crane LA, Babbel C, Barrow J, Marin M, Stokley S, Broder K, Beaty B, Kempe A. Febrile Seizures and Measles, Mumps, Rubella, and Varicella Virus Vaccine (MMRV): A National Survey of Physicians. Poster symposium presentation, Pediatric Academic Societies' Annual Meeting, Baltimore, Maryland, May 2-5, 2009.

Suh CA, Stokley S, Saville AW, Benton K, Daley MF, Dickinson ML, Kempe A. How Successful is Reminder/Recall in Improving Immunization Rates for Adolescents in Pediatrics and Family Medicine Practices? Oral Presentation, 43rd National Immunization Conference, Dallas, Texas, March 30-April 2, 2009.

Presentations

Daley MF. Logistics of Universal Childhood Influenza Vaccination. 2009 National Influenza Vaccine Summit. Dallas, TX. July 1, 2009.

Kempe, A. Provider Attitudes and Practices Regarding Herpes Zoster Vaccine and Perceived Barriers. ACIP Advisory Committee on Immunization Practices Meeting. Atlanta, GA, February 25-26, 2009.

Kempe, A. Providers’ Opinions on the Use of MMRV Vaccine. ACIP Advisory Committee on Immunization Practices Meeting. Atlanta, GA, February 25-26, 2009.

Publications

Allison MA, Daley MF, Barrow J, Crane LA, Beaty BL, Allred N, Kempe A. High influenza vaccination coverage in children with high-risk conditions despite a vaccine shortage. Archives of Pediatric and Adolescent Medicine 2009 May;163(5):426-31.

Daley MF, Hennessey KA, Weinbaum CM, Stokley S, Hurley LP, Crane LA, Beaty BL, Barrow JC, Babbel CI, Dickinson LM, Kempe A. Physician Practices Regarding Adult Hepatitis B Vaccination: A National Survey. Am J Prev Med. 2009 Jun;36(6):491-6. Epub 2009 Apr 11.

Daley, MF, Curtis, CR, Pyrzanowski J, Barrow J, Benton K, Abrams L, Federico S, Juszczak L, Melinkovich P, Crane LA, Kempe A. Adolescent Immunization Delivery in School-Based Health Centers: A National Survey. Journal of Adolescent Health. 2009 In Press.

Kempe A, Babbel C, Wallace GS, Stokley S, Daley MF, Crane LA, Beaty B, Black SR, Barrow J, Dickinson LM. Physicians’ Reported Knowledge and Practice Regarding Interim Recommendations for the Use of Hib Vaccine During Hib Vaccine Shortages. Pediatrics. 2009 Re-submitted.

Kempe A, Hurley L, Stokley S, Daley MF, Crane LA, Beaty BL, Dickinson LM, Babbel C, Barrow J, Steiner JF. Pneumococcal Vaccination in General Internal Medicine Practice: Current Practice and Future Possibilities. J of Gen Internal Med. Dec;23(12):2010-3. Epub 2008 Oct 2.

Kempe A, Patel MM, Daley MF, Crane LA, Beaty B, Stokley S, Barrow J, Babbel C, Dickinson LM, Tempte JL, Parashar, UD. Adoption of Rotavirus Vaccination by U.S. Pediatricians and Family Physicians. Pediatrics. 2009 In Press. McQuillan L, Daley MF, Stokley S, Crane LA, Beaty BL, Barrow J, Babbel C, Dickinson LM, Kempe A. Impact of the 2004-2005 Influenza Vaccine Shortage