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James Maller, Professor - EMERITUS

Ph.D. (1974), University of California at Berkeley


 

 

 

 

Contact Info:

Molecular Biology
University of Colorado

James Maller, Ph.D.  Research One South
(RC1-South), Room 10122
Jim.Maller@ucdenver.edu Phone: 303-724-1623

 

Dr. Maller's laboratory studies the molecular regulation of decision points in the cell cycle during which commitments are made to enter DNA synthesis or mitosis.  Both checkpoint decisions are regulated by integrated signals that control the activity of protein kinases and phosphatases which regulate the phosphorylation state of key enzymes.  The overall goal is to learn how the cellular decision to proceed in the cell cycle is elaborated at these decision points.  Dr. Maller is also interested in signal transduction pathways that utilize sequential phosphorylation and activation of several protein kinases, resulting in a cascade of signaling modules important for growth control and integrated cellular function.

 

Eyers, P.A., Erikson, E., Chen, L.G., and Maller, J.L. (2003) A Novel Mechanism for Activation of the Protein Kinase Aurora A. Curr. Biol. 13, 691-697.

Tunquist, B.J., Eyers, P.A., Chen, L.G., Lewellyn, A.L. and Maller, J.L. (2003) Spindle Checkpoint Proteins Mad1 and Mad2 Are Required for Cytostatic Factor (CSF)-Mediated Metaphase Arrest. J. Cell Biol., 163, 1231-1242.

Eyers, P.A. and Maller, J.L. (2004) Regulation of Xenopus Aurora A Activation by TPX2. J. Biol. Chem. 279, 9008-9015.

Liu, J., Lewellyn, A.L., Chen, L.G., and Maller, J.L. (2004) The Polo Box Is Required for Multiple Functions of Plx1 in Mitosis. J. Biol. Chem. 279, 21367-21373.

Erikson, E., Haystead, T.A., Qian, Y-W, and Maller, J.L. (2004) A Feedback Loop in the Polo-like Kinase Activation Pathway. J. Biol. Chem. 279, 32,219-32,224.

Conn, C.W., Lewellyn, A.L., and Maller, J.L. (2004) The DNA Damage Checkpoint In Embryonic Cell Cycles Is Dependent on the DNA to Cytoplasmic Ratio. Dev. Cell 7, 275-281.

Matsumoto, Y. and Maller, J.L. (2004) A Centrosomal Localization Signal in Cyclin E Required for Cdk2-Independent S Phase Entry. Science, 306, 885-888.

Eyers, P.A., Liu, J., Hayashi, N.R., Lewellyn, A.L., Gautier, J. and Maller, J.L. (2005) Regulation of the G2/M Transition in Xenopus Oocytes by the cAMP-Dependent Protein Kinase. J. Biol. Chem., 280, 24339-24346.

Eyers, P., Churchill, M., and Maller, J.L. (2005) The Aurora A and Aurora B Protein Kinases: A Single Amino Acid Difference Controls Intrinsic Activity and Activation by TPX2. Cell Cycle, 4, 784-789.

Liu, J.J. and Maller, J.L. (2005) Calcium Elevation at Fertilization Coordinates Phosphorylation of XErp1/Emi2 by Plx1 and CaMKII to Release Metaphase Arrest by Cytostatic Factor. Curr. Biol., 15, 1458-1468.

Liu, J. and Maller, J.L. (2005) The Xenopus Polo-like Kinase Plx1: A Multifunctional Mitotic Kinase Oncogene 24, 238-247.