Combined, the Directors of the Human Immunology and Immunotherapy Initiative are leaders in the fields of tolerance and autoimmunity, allergy and clinical immunology, and cancer biology. Briefly, the work in the laboratory of John Cambier is currently focused on problems related to tolerance and autoimmunity, with specific focus on the basis of antigen unresponsiveness of anergic B cells, and mechanisms underlying loss of anergy leading to autoimmune disorders such as Systemic Lupus Erythematosus, Type 1 Diabetes and Rheumatoid Arthritis. The laboratory of Andrew Fontenot is focused on the role of T cells in the development of lung disease, with particular interest in determining the mechanism by which CD4+ T cells recognize and become sensitized to specific antigens that have been shown to play a role in the progression of lung disease. Dan Theodorescu manages an active translational molecular biology lab focused on identifying the molecular mechanisms leading to bladder and prostate cancer metastasis and their potential applications to patients with these diseases.
More detailed descriptions of their expertise, research programs, and publications can be found by clicking on the individual directors names below.