Welcome to the University of Colorado School of Medicine on the Anschutz Medical Campus. We are a Top Ten Medical School in primary care, pediatrics, family medicine and rural medicine, and offer physical therapy and physician assistant programs.

ExPASy Molecular Biology Server

The ExPASy (Expert Protein Analysis System) proteomics server of the Swiss Institute of Bioinformatics (SIB). This server is dedicated to the analysis of protein sequences and structures as well as 2-D PAGE.

ProtParam tool

A tool for computating various physical and chemical parameters for a given protein stored in SWISS-PROT or TrEMBL or for a user entered sequence. The computed parameters include the molecular weight, theoretical pI, amino acid composition, atomic composition, extinction coefficient, estimated half-life, instability index, aliphatic index and grand average of hydropathicity (GRAVY). (References).

CLAMP Software

A software program designed to interpret complex interactions recorded on biosensors. It combines numerical integration and non linear global curve fitting routines.

Protein Interaction Facility

David Myszka, Director. Some information about analytical ultracentrifugation, titration calorimetry and optical biosensors (Biacore).

Unit Conversions

Temperature, length, energy, pressure, volume, density, specific volume, specific heat (entropy), enthalpy, thermal conductivity, viscosity, and coefficient of heat transfer conversions. Just enter a number and we will convert it for you!

Quadratic Formula Solver

Enter your coefficients and receive the answers!

Constants

Constant	Value	Unit
Avogadro constant	6.022045 * 1023	mol-1
Boltzmann constant	1.380662 * 10-23	J mol-1 K-1
	3.298 * 10-24	cal mol-1 K-1
Electronic charge	1.602 * 10-19	C
Faraday constant	96,485	C mol-1
Molar gas constant	8.31441	J mol-1 K-1
	0.082057 * 10-3	m3 atm mol-1 K-1
	1.987	cal mol-1 K-1
Plank's constant	6.626176 * 10-34	J s
Velocity of light	2.998 * 108	m s-1
Base of natural logarithms	2.7183
Pi	3.1416

More Information: E. R. Cohen & N. B. Taylor, J. Phys. Chem. Ref. Data, vol 2(4), 1973.

Circular Dichroism

CD 222:208 ratio 1.10 => Coiled coil
CD 222:208 ratio 0.90 => Helix

Molar Ellipticity Online Conversion

Thermo-dynamics of Protein Unfolding

Protein	pH	Delta H° (kcal mol-1)	Delta S° (kcal K-1 mol-1)
Trypsin	2.0	67.6	213
Soybean trypsin inhibitor	3.0	57.3	180
Chymotrypsinogen	2.0	99.6	316
Chymotrypsinogen	3.0	143	432

National Institute of Standards and Technology

Elemental data index, physical constants, atomic spectroscopic data, molecular spectrscopic data, ionization data, x-ray and gamma-ray data, radiation dosimetry data, nuclear physics data, etc.

Reflexive Film