Karen Jonscher, PhD, Proteomics Director
Dr. Jonscher has over 20 years of experience in biological mass spectrometry, including instrument development, method design and data interpretation and validation. She collaborates with and assists researchers in developing detailed analytical plans and constructing realistic budgets for proteomics-based projects. She has expertise in a variety of mass spectrometry-based proteomics sample preparation workflows, including protein fractionation, immunoprecipitation, gel electrophoresis, nanscale HPLC and isoelectric separation of peptides. She has extensive experience in proteomics data interpretation and manual validation that helps ensure the reliability of results obtained from proteomic experiments.
Dr. Jonscher is affiliated with the Mucosal Inflammation Program and the Center for Hypoxia and Ischemia Research within the Department of Anesthesiology at the University of Colorado Denver. Her current research interests focus on protein regulation by post-translational modification, proteomics of epithelial cells in a model of hypoxia, and mechanisms behind fetal membrane rupture. The Proteomics division also is part of a Tissue Analysis and Technology Core serving the NIDDK Multi-Disciplinary Approach to Pelvic Pain Network.