Immunization of HIV-infected children as a marker of immune reconstitution Antiviral therapy in infants and children
Kawasaki's Disease, Bioterrorism, Antibiotics, Toxin-Mediated Disease and Vaccines
Clinical pharmacology, Antiviral medications, HIV, Intracellular pharmacology of nucleoside analogs for HIV and pharmacogenetics of antiretroviral agents.
Positive-strand RNA virus replication and dsRNA-activated innate immune reponses; Poliovirus, Hepatitis C virus
CNS Infections, West Nile Virus, Encephalitis
Bacterial Genetics and Physiology, Tuberculosis (TB)
Immunotherapy and Th17, Vaccines
Pathogenesis of autoimmune disease, Genes that may be involved in the development of systemic lupus erythematosus (SLE), B cells, Complement receptor 2 (CR2; CD21)
Young women's breast cancer and immunology/immunotherapy
ABSL-3 facilities. Expertise for animal testing of vaccines against diverse pathogens, most of which are Select Agents; Influenza; Animal models
Biology, Microbiology Medicine, Pediatrics, Vaccines
Design and implementation of randomized clinical trials to improve the treatment of tuberculosis and HIV infection; International Health
HIV gp120 inactivation of T cells, Molecular basis of anergy, a particular type of immunologic tolerance, molecular basis of integration of signals transduced concurrently by B cell antigen receptors (BCR), the type 2 complement receptors (CR2) and receptors for immunoglobulin G constant regions (Fc?RIIB 1), signal transduction that occurs in B cells during cognate interactions with helper T cells, the decline in B cell function seen during aging.
HIV treatment HHV-8; International Health; Africa
Biological Sciences, Medicine
Biopharmaceutical Sciences, Cadriothoracic, Transplant Immunology, Pharmacology, Toxicology
|Chu, Hon Wei|
Bacterial infection in airway mucosa of COPD and asthma patients
Immunology, Infectious Disease (Virology), Inflammation
Hypoxia; Transcriptional signaling by the hypoxia-inducible factors (HIFs); Musosal Inflammation; Inflammatory Bowel Diseases
Immunopathogenesis of HIV infection; Sex-based differences in HIV, infection; Women's health
Virology, emerging diseases and zoonoses
Respiratory Infectious Diseases, Bronchiectasis, Mycobacterial Infections
Clinical and epidemiological studies of tuberculosis (TB) and nontuberculous mycobacterial (NTM) infections; International health
|De Groote, Mary Ann|
Tuberculosis (TB); non-tuberculosis mycobacteria (NTM)
Pre-clinical identification of autoimmune disease. Multi-centered trials; Relationship between genetics, environmental exposures, and the development of rheumatoid arthritis-related autoimmune disease. Building models for the prediction of future development of autoimmune disease.
Structural biology, immunology, developmental biology
How pathogenic bacteria evade and manipulate mammalian immune systems. Molecular mechanisms of Typhoid fever; Immunology; Microbiology.
Immunology, dendritic cells, HIV
Cytokines; Immunology; Autoimmune disease
Mycobacterium spp. (TB, NTM); Proteomics; Vaccines; Diagnostics; Respiratory
Vaccine adjuvants; pulmonary immunity; enteric immunity; bacterial pathogens (Burkholderia, Francisella, Yersinia); Respiratory Immunology
T cells in the development of lung disease.
Determining the mechanism by which CD4+ T cells recognize the beryllium antigen in the context of HLA-DP2. We have recently determined the structure of HLA-DP2 and this structure defines a potential beryllium binding site. The immunologic mechanisms involved in the progression from beryllium sensitization and disease as well as the development of biomarkers that could potentially detect this progression in the absence of invasive procedures is also a major interest. Lung microbiome that characterize the lung in different stages of HIV disease and whether a broadened microbiome could contribute to the early onset of lung disease in HIV-infected patients. Respiratory immunology.
Interactions between commensal microorganisms, pathogens, and the mucosal immune system in human health and disease; Microbiome; Enteric disease; Inflammatory bowel disease; HIV.
Effects of smoking on pulmonary immune responses; HLA epitopes and immune medicated diseases; Respiratory immunology
Lung Mucosal Immunity; Asthma COOPD; Respiratory Immunology
Microarray Core Cancer Research; Molecular biology
Structure and assembly of small DNA viruses, New human papillomavirus (HPV) vaccines
The Role of Eicosanoids in Pulmonary Hypertension and Lung Cancer; Respiratory Immunology; molecular biology
Regulation of bacterial gene expression. Molecular biology of host-bacterial pathogen interactions; Streptococcus pneumoniae-pathogenic mechanisms and new approaches to vaccine development. Respiratory Immunology and Microbiology; Vaccines.
Vitamin D deficiency and immune response to vaccines; Immunosenescence and vaccination in older adults
Pediatric infectious disease; vaccines; Kawasaki's disease
Hypoxia; Transcriptional signaling by the hypoxia-inducible factors (HIFs); Mucosal Inflammation; Inflammatory Bowel Diseases
Cancer vaccines; immune suppression; cell stress; bexosome biology; Cancer vaccines
Pediatric; Critical Care
Immunology; Cancer; Tumor biology, Autoimmunity, Flow cytometry
Basic Immunology, Cancer, Cellular and Molecular Biology, Molecular Genetics, Molecular Immunology, Stem Cells
Cell Biology of Inflammation, Recognition and removal of apoptotic cells, Innate Immunity; Respiratory Immunology
Functional genomics high-throughput sequencing; computational biology; RNA
The roles of complement receptors and membrane regulatory proteins in the immune response with a special emphasis on B cells and autoimmunity. The role of autoantibodies and the evolution of autoimmunity in rheumatoid arthritis (RA) from the pre-symptomatic autoantibody-positive period through the onset of clinically active disease.
Characterization of coronavirus receptors and analysis of the role of receptor specificity in coronavirus pathogenesis and evolution. We are interested in molecular mechanisms that determine how coronaviruses jump from one host to another to cause emerging diseases of humans and animals; Influenza; Vaccines.
Molecular methods to study the genetics and regulation of bacterial protein toxins, their roles in pathogenesis of infectious diseases, and their uses for vaccine development.
HIV, Innate Immunity, Vitamin D, Bacterial Co-Infection
Immunology, Mycobacteria Microbiology, including Tuberculosis (TB)
Pulmonary Dendritic Cells; Respiratory Immunology
Vaccine - preventable disease; HIV; Streptococcus pneumoniae; Influenza; Mucosal Immunology; Respiratory Immunology.
Biological mass spectrometry, instrument development, method design and data interpretation and validation; Pretomic.
Breast cancer, Cancer stem cells
Chronic infectious diseases and cancer, Adjuvant development for vaccines that induce cellular immunity; Immunology.
Immunodeficiency diseases, Reconstitution F Immune responses; Immunology.
Design of clinical trials, Survival analysis, Longitudinal data, Bayesian methods in clinical trials, Group sequential trial design, Methods for monitoring clinical trials; Biostatistics.
Genomics, molecular evolution and the microbiome
Cytomegalovirus molecular biology and pathogenesis; Herpesvirus transmission and immunity; non-coding RNA's; chromatin
Invasive mucosal bacterial pathogens. Innate Immunity. Cytokine signaling. Natural Killer Cells; Respiratory Immunology.
Vaccinology, Herpesvirus latency, Immune response to herpesvirus; Immunosenescence.
Brain, nervous, and spinal tumors; pituitary tumors; cancer immunotherapy and vaccines
Expertise in celiac disease autoimmunity, Inflammatory bowel disease
Basic Immunology; T cells; Vaccine adjuvants
Pulmonary Disease Research. Biology of alveolar type II epithelial cells. Lipogenesis in alveolar type II cells. Role of alveolar epithelium in environmental lung disease. Role of alveolar epithelium in pulmonary fibrosis. Response of alveolar epithelial cells to viral infections.
Biostatistics, Infectious Diseases; HIV
Melanoma-induced immunosuppression; Cancer; Immunology
Microbiology antibiotic resistance; Innate host defense; Salmonella; Staphylococcus aureus
Mechanisms of lipid droplet synthesis Lipid droplets (LDs); Reproductive and Women's health
HIV; Women's Health; Aging
Interation of Hepatitis C (HCV) with adaptive immune cells and antigen-presenting cells from the liver including Kupffer cells (liver macrophages), T cells and dendritic cells. I collaborate with Drs Rosen, and Colgan within the department of Gastroenterology and Hepatology.
Cancer vaccines, tumor immunology, immunotoxicology
Mammary gland biology, lactation, mouse models of mammary cancer
|Morrison, Thomas "Tem"|
Arboviruses, Virus interactions with host inflammatory response; Arthritis
Pediatric Critical Care Medicine (PICU)
Type 1 diabetes, autoimmune diseases, retroviral expression system, high-throughput sequencing
The regulation of the development of the normal mammary gland.
Pulmonary surfactant lipids and anti-viral effects in the innate immunity of the lung; Respiratory Immunology
Ribozyme biochemistry; molecular ecology of extreme ecosystems; Microbiome
Mechanisms of HIV-associated CD4+ T cell dysfunction; Flow cytometry
tuberculosis (TB), mycobacteria, polyketide synthases, cutinases
Molecular immunology, ion homeostasis regulation and signaling in immune cells
Arboviral diasease; West Nile Virus; Dengue; Yellow Fever; Vaccine development; International Health
Pure theoretical (mathematical or computational) biology to purely empirical research (PCR and sequencing to obtain critical sequence biodiversity information, or site-directed mutagenesis, gene synthesis and directed evolution to test computationally-derived theories of protein sequence and structure/function relationships); Evolutionary biology.
Hospital epidemiology antibiotic resistance; Infectious disease
Virus-host interactions in human papillomavirus (HPV) infection and oncogenesis
Sinus and Skull Base Diseases; Sinusitis; Microbiome
Cartilage biology, osteoarthritis, musculoskeletal epidemiology
Diagnosis, treatment and prevention of tuberculosis (TB)
Hepatology; Hepatitus C (HCV), HIV; Immunology
Cystic fibrosis, adaptive immunity in cystic fibrosis, biomarkers of lung inflammation; Respiratory immunity
Virology; Immunology; HIV; animal models
Adenovirus vectors, Retrovirus vectors; Virology
Hantaviruses, arenaviruses, T cell immunology
Aging, immune function, exercise, hormone supplmentation; Immunosenescence
Alpha-1-antitrypsin biology; Molecular mechanisms Cytokines; Signal transduction; Bacterial pathogenesis
Genetics and biochemistry of Pseudomonas aeruginosa pathogenesis. Vaccine development for P. aeruginosa.
Respiratory tract infections; International Health
Genomics, Structural Biology, Computational Biology, Respiratory Disease, including tuberculosis (TB)
Asthma, lower airway microbiome
|Tan, Aik Choon|
Airway epithelial biology, environmental toxicants and asthma, innate/mucosal immunity; Respiratory Immunology
Cell Death Cancer Therapy
B Cell ; Antibody response; Immunology
Central Nervous System (CNS) Infections; Virology
|Van Dyk, Linda|
Immunology, Virology, Virus-associated tumors
Cellular, molecular and biochemical approaches to understand the role that mononuclear phagocytes play in the host response to intracellular pathogenic microorganisms. We are currently studying two aspects of the innate immune responses of mononuclear phagocytes to the intracellular enteric bacteria Salmonella typhimurium. I plan to extend our expertise in macrophage biology to study the pathogenesis of the biowarfare intracellular pathogen Burkholderia; Mucosal Immunology.
Membrane biogenesis, lipid metabolism and biochemistry, pulmonary surfactant proteins and lipids, innate immunity, yeast genetics; Respiratory disease
Mycobacterium tuberculosis (TB) bacteriology, Latency, drug tolerance and pathogenesis Burkholderia bacteriology, Respiratory disease
Expression Profiling, Tuberculosis (TB); Respiratory immunology; International Health
Influenza virus-induced innate immunity and lung; Respiratory immunology
Brain Tumor immunology, Brain tumor stems cells, Invasive neurophysiological monitoring; Vaccines
Immune restoration in HIV-infected patients. I established virologic correlates of immune reconstitution in children and adults, and identified immune correlates of protection against CMV infection in HIV-infected patients on HAART. I recently described an inhibitory mechanism of cellular immunity operative in HIV-infected patients, but not in healthy individuals. This is the current object of more in-depth studies at sub-cellular level. I developed several lines of investigation of CMV-specific immunity in transplant patients, including the following: impact of CMV infection on graft rejection;immune restoration in bone marrow transplant recipients and immune correlates of protection against CMV infections; use of dendritic cells for establishment of CMV-specific immunity in stem cell and cord blood transplant recipients. Immunodeficiency; Immunology
Human tissue culture - esp. culture of human blood and intestinal tissue, and immune function assays. Dendritic cell and T cell function, flow cytometry, CFSE proliferation, ELISA. Isolation of multiple cell types. Mucosal Immunology; Vaccines.
Epithelial lung research, lung cancer, signaling transduction; Respiratory disease
Chronic lung diseases (e.g., asthma and COPD) and bacterial infections; Immunology (e.g., mucosal immunology and cellular immunology); Respiratory immunology.
Neuroimmunology, epitopes and biomarkers
Biostatastics (data analysis, study design, consulting), genetic association study