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Research Interest Groups


 

Cell Biology

Cell biology is a dynamic discipline that combines the interests and methods of a wide variety of scientific fields. Studies of cell function are central to modern biological research as they focus upon investigating the basic structural and functional unit of life: the cell. By applying a wide range of experimental approaches to the study of cellular processes, including biochemical and physical analysis of molecules and cells in culture, and morphological methods, cell biologist have made major discoveries that have had a dramatic impact on human health. This key link between fundamental studies of cell function and their relevance to disease is highlighted by the work of the Cell Biology Faculty within the Graduate Program in Cell Biology, Stem Cells and Development. Ongoing studies in the areas of membrane trafficking, membrane dynamics, cell signaling, motility, organelle composition and function, studies of the cytoskeleton and extracellular matrix provide important insights and information that is ultimately crucial for developing effective treatments for cancer, heart disease, AIDS, and a host of other diseases that disrupt normal cell function.

Name Research Interests
Lynne Bemis MicroRNAs and cancer
Brad Bendiak Structural analysis of protein glycosylation using NMR and mass spectrometry
Steve Britt Visual system development and function using molecular/genetic approaches in Drosophila
Richard Davis Small RNAs and post-transcriptional gene regulation during nematode gametogenesis and early development
Brian Doctor Molecular interactions of actin cytoskeleton and membranes in mammalian hepatobiliary system
Holger Eltzschig  Center for Hypoxia and Ischemia Research (CHaIR)
Thomas Evans Molecular and cellular mechanisms of early embryonic development in C. elegans using genetic and biochemical approaches
Thomas Finger Development and organization of taste and smell
Joan Hooper Cell determination, developmental patterning and hedgehog signaling in drosophila
Kathryn Howell Structure/function of the Golgi complex using mass spectrometry, proteomics, functional assays, and high resolution 3D structure
John Hutton Secretory granule biogenesis and exocytosis in the endocrine pancreas: role in human diabetes
Karen King Cellular response to mechanical loading in skeletal tissues
Peter Koch Cell adhesion molecules in embryonic development and diseases
Wendy Macklin Oligodendrocyte development and disease
Jim McManaman Mammary gland development and function
Karl Pfenninger Regulation of pseudopod attachment in nerve growth cones/cancer cells
Rytis Prekeris Molecular mechanisms regulating the establishment and maintenance of cellular polarity in epithelial cells and neurons
Yosef Refaeli The role of MYC in the regulation of hematopoietic stem cell self-renewal, proliferation, differentiation and survival
Diego Restrepo Olfactory signal transduction and olfactory sensory coding using electrophysiological, morphological and molecular techniques
Jane Reusch Function of the CREB transcription factor in cellular homeostasis, and the relationship between CREB dysfunction and the complications of diabetes
Mary Reyland Role of protein kinase C delta signaling in apoptosis and cancer
Sue Reynolds Lung stem cell function: roles for Wnt signaling
Pepper Schedin Stromal-epithelial interactions in mammary gland development, carcinogenesis and breast cancer prevention
Geeta Sharma Mechanisms of synaptic plasticity
Xiao-Jing Wang TGFbeta signaling in cancer and skin development
Virginia Winn Human Placental Development, Preeclampsia Pathogenesis

 

Stem Cells

Stem Cell Biology Research offers enormous therapeutic potential for a wide range of clinical disorders including Parkinson's disease, diabetes, chronic heart disease, end-stage renal disease, liver failure and cancer. Realizing the promise of using stem cells in treating human disease will ultimately depend upon defining the cellular and molecular mechanisms that regulate cell proliferation and differentiation. These fundamental principles are at the heart of modern Cell Biology, Stem Cells and Development and highlight the dynamic interdisciplinary work being undertaken by the faculty and graduate students in the Cell Biology, Stem Cells and Development Graduate Program at the University of Colorado Anschutz Medical Campus.

Name Research Interests
Bruce Appel Development and repair of the vertebrate nervous system
Kristin Artinger Molecular, genetic and developmental mechanisms involved in the patterning of the early spinal cord (neural plate) during vertebrate embryogenesis
Vivek Balasubraniam Pulmonary development and injury
Linda Barlow Developmental neurobiology; patterning and formation of sensory organs
Thomas Evans Molecular and cellular mechanisms of early embryonic development in C. elegans using genetic and biochemical approaches
Jim Hagman Regulation of B lymphocyte - specific transcription and differentiation
Karen King Cellular response to mechanical loading in skeletal tissues
Peter Koch Cell adhesion molecules in embryonic development and diseases
Maranke Koster  Signaling pathways that control epidermal development and differentiation
Karl Pfenninger Regulation of pseudopod attachment in nerve growth cones/cancer cells
Yosef Refaeli The role of MYC in the regulation of hematopoietic stem cell self-renewal, proliferation, differentiation and survival
Sue Reynolds Lung stem cell function: roles for Wnt signaling
Dennis Roop Skin development and disease
Geeta Sharma Mechanisms of synaptic plasticity
Xiao-Jing Wang TGFbeta signaling in cancer and skin development
Trevor Williams  Transcriptional regulation of mouse embryonic development and the role of transcription factors in mammary gland development and breast cancer

 

Development

All animals begin life as a single cell, the result of a fusion between sperm and egg. Through a staggering multitude of molecular, cellular and tissue level events, a properly organized, multicellular embryo is formed. In the last decade, our understanding of many of these processes has expanded dramatically due to the advent of cellular, molecular biological and genetic approaches. Intriguingly, many of these processes first recognized in developmental contexts have also been implicated in human disease. These types of fundamental studies form the core of cutting edge research in Developmental Biology by faculty of the Graduate Program in Cell Biology, Stem Cells and Development at the University of Colorado Anschutz Medical Campus.

Name Research Interests
Bruce Appel Development and repair of the vertebrate nervous system
Kristin Artinger Molecular, genetic and developmental mechanisms involved in the patterning of the early spinal cord (neural plate) during vertebrate embryogenesis
Vivek Balasubraniam Pulmonary development and injury
Linda Barlow Developmental neurobiology; patterning and formation of sensory organs
Steve Britt Visual system development and function using molecular/genetic approaches in Drosophila
John Caldwell Functional regulation of ion channels in plasma membranes and Golgi membranes using electrophysiology and molecular biology
David Clouthier Signaling pathways regulating craniofacial and cardiovascular development
Stijn DeLanghe Lung development and regeneration
Thomas Evans Molecular and cellular mechanisms of early embryonic development in C. elegans using genetic and biochemical approaches
Thomas Finger Development and organization of taste and smell
Jim Hagman Regulation of B lymphocyte - specific transcription and differentiation
Joan Hooper Cell determination, developmental patterning and hedgehog signaling in drosophila
Peter Koch Cell adhesion molecules in embryonic development and diseases
Maranke Koster Signaling pathways that control epidermal development and differentiation
Wendy Macklin Oligodendrocyte development and disease
Jim McManaman Mammary gland development and function
Lee Niswander Genetic mechanisms of limb, lung, and neural development
Karl Pfenninger Regulation of pseudopod attachment in nerve growth cones/cancer cells
Rytis Prekeris Molecular mechanisms regulating the establishment and maintenance of cellular polarity in epithelial cells and neurons
Sue Reynolds Lung stem cell function: roles for Wnt signaling
Dennis Roop Skin development and disease
Pepper Schedin Stromal-epithelial interactions in mammary gland development, carcinogenesis and breast cancer prevention
Xiao-Jing Wang TGFbeta signaling in cancer and skin development
Trevor Williams Transcriptional regulation of mouse embryonic development and the role of transcription factors in mammary gland development and breast cancer
Virginia Winn Human Placental Development, Preeclampsia Pathogenesis