Cell biology is a dynamic discipline that combines the interests and methods of a wide variety of scientific fields. Studies of cell function are central to modern biological research as they focus upon investigating the basic structural and functional unit of life: the cell. By applying a wide range of experimental approaches to the study of cellular processes, including biochemical and physical analysis of molecules and cells in culture, and morphological methods, cell biologist have made major discoveries that have had a dramatic impact on human health. This key link between fundamental studies of cell function and their relevance to disease is highlighted by the work of the Cell Biology Faculty within the Graduate Program in Cell Biology, Stem Cells and Development. Ongoing studies in the areas of membrane trafficking, membrane dynamics, cell signaling, motility, organelle composition and function, studies of the cytoskeleton and extracellular matrix provide important insights and information that is ultimately crucial for developing effective treatments for cancer, heart disease, AIDS, and a host of other diseases that disrupt normal cell function.
| Name |
Research Interests |
| James Crapo |
Molecular regulation of superoxide dismutases in lung biology |
| Brian Doctor |
Molecular interactions of actin cytoskeleton and membranes in mammalian hepatobiliary system |
| Holger Eltzschig |
Center for Hypoxia and Ischemia Research (CHaIR) |
| Joan Hooper |
Cell determination, developmental patterning and hedgehog signaling in drosophila |
| Kathryn Howell |
Structure/function of the Golgi complex using mass spectrometry, proteomics, functional assays, and high resolution 3D structure |
| John Hutton |
Secretory granule biogenesis and exocytosis in the endocrine pancreas: role in human diabetes |
| Karen King |
Cellular response to mechanical loading in skeletal tissues |
| Peter Koch |
Cell adhesion molecules in embryonic development and diseases |
| Wendy Macklin |
Oligodendrocyte development and disease |
| Karl Pfenninger |
Regulation of pseudopod attachment in nerve growth cones/cancer cells |
| Rytis Prekeris |
Molecular mechanisms regulating the establishment and maintenance of cellular polarity in epithelial cells and neurons |
| Mary Reyland |
Role of protein kinase C signaling in programmed cell death |
| Pepper Schedin |
Stromal-epithelial interactions in mammary gland development, carcinogenesis and breast cancer prevention |
| Geeta Sharma |
Mechanisms of synaptic plasticity |
| Alexander Sorkin |
Molecular basis of endocytosis and trafficking of growth factor receptors |
| Xiao-Jing Wang |
TGFbeta signaling in cancer and skin development |
All animals begin life as a single cell, the result of a fusion between sperm and egg. Through a staggering multitude of molecular, cellular and tissue level events, a properly organized, multicellular embryo is formed. In the last decade, our understanding of many of these processes has expanded dramatically due to the advent of cellular, molecular biological and genetic approaches. Intriguingly, many of these processes first recognized in developmental contexts have also been implicated in human disease. These types of fundamental studies form the core of cutting edge research in Developmental Biology by faculty of the Graduate Program in Cell Biology, Stem Cells and Development at the University of Colorado Anschutz Medical Campus.
| Name |
Research Interests |
| Bruce Appel |
Development and repair of the vertebrate nervous system |
| Kristin Artinger |
Molecular, genetic and developmental mechanisms involved in the patterning of the early spinal cord (neural plate) during vertebrate embryogenesis |
| Linda Barlow |
Developmental neurobiology; patterning and formation of sensory organs |
| Steve Britt |
Visual system development and function using molecular/genetic approaches in Drosophila |
| John Caldwell |
Functional regulation of ion channels in plasma membranes and Golgi membranes using electrophysiology and molecular biology |
| David Clouthier |
Signaling pathways regulating craniofacial and cardiovascular development |
| Thomas Evans |
Molecular and cellular mechanisms of early embryonic development in C. elegans using genetic and biochemical approaches |
| Thomas Finger |
Development and organization of taste and smell |
| Eva Grayck |
Hypoxia and pulmonary hypertension |
| Joan Hooper |
Cell determination, developmental patterning and hedgehog signaling in drosophila |
| Peter Koch |
Cell adhesion molecules in embryonic development and diseases |
| Maranke Koster |
Signaling pathways that control epidermal development and differentiation |
| Wendy Macklin |
Oligodendrocyte development and disease |
| Susan Majka |
Mesenchymal stem cells in pulmonary hypertension |
| Margaret Neville |
Mammary gland biology and the molecular switch between pregnancy and lactation |
| Lee Niswander |
Genetic mechanisms of limb, lung, and neural development |
| Karl Pfenninger |
Regulation of pseudopod attachment in nerve growth cones/cancer cells |
| Dennis Roop |
Skin development and disease |
| Xiao-Jing Wang |
TGFbeta signaling in cancer and skin development |
| Trevor Williams |
Transcriptional regulation of mouse embryonic development and the role of transcription factors in mammary gland development and breast cancer |
| Virginia Winn |
Human Placental Development, Preeclampsia Pathogenesis |
Stem Cell Biology Research offers enormous therapeutic potential for a wide range of clinical disorders including Parkinson's disease, diabetes, chronic heart disease, end-stage renal disease, liver failure and cancer. Realizing the promise of using stem cells in treating human disease will ultimately depend upon defining the cellular and molecular mechanisms that regulate cell proliferation and differentiation. These fundamental principles are at the heart of modern Cell Biology, Stem Cells and Development and highlight the dynamic interdisciplinary work being undertaken by the faculty and graduate students in the Cell Biology, Stem Cells and Development Graduate Program at the University of Colorado Anschutz Medical Campus.
| Name |
Research Interests |
| Bruce Appel |
Development and repair of the vertebrate nervous system |
| Kristin Artinger |
Molecular, genetic and developmental mechanisms involved in the patterning of the early spinal cord (neural plate) during vertebrate embryogenesis |
| Linda Barlow |
Developmental neurobiology; patterning and formation of sensory organs |
| Peter Koch |
Cell adhesion molecules in embryonic development and diseases |
| Maranke Koster |
Signaling pathways that control epidermal development and differentiation |
| Susan Majka |
Mesenchymal stem cells in pulmonary hypertension |
| Dennis Roop |
Skin development and disease |
| Geeta Sharma |
Mechanisms of synaptic plasticity |
| Xiao-Jing Wang |
TGFbeta signaling in cancer and skin development |
| Trevor Williams |
Transcriptional regulation of mouse embryonic development and the role of transcription factors in mammary gland development and breast cancer | |
|
Cell Biology
Cell biology is a dynamic discipline that combines the interests and methods of a wide variety of scientific fields. Studies of cell function are central to modern biological research as they focus upon investigating the basic structural and functional unit of life: the cell. By applying a wide range of experimental approaches to the study of cellular processes, including biochemical and physical analysis of molecules and cells in culture, and morphological methods, cell biologist have made major discoveries that have had a dramatic impact on human health. This key link between fundamental studies of cell function and their relevance to disease is highlighted by the work of the Cell Biology Faculty within the Graduate Program in Cell Biology, Stem Cells and Development. Ongoing studies in the areas of membrane trafficking, membrane dynamics, cell signaling, motility, organelle composition and function, studies of the cytoskeleton and extracellular matrix provide important insights and information that is ultimately crucial for developing effective treatments for cancer, heart disease, AIDS, and a host of other diseases that disrupt normal cell function.
| Lynne Bemis |
MicroRNAs and cancer |
| Brad Bendiak |
Structural analysis of protein glycosylation using NMR and mass spectrometry |
| Steve Britt |
Visual system development and function using molecular/genetic approaches in Drosophila |
| Richard Davis |
Small RNAs and post-transcriptional gene regulation during nematode gametogenesis and early development |
| Brian Doctor |
Molecular interactions of actin cytoskeleton and membranes in mammalian hepatobiliary system |
| Holger Eltzschig |
Center for Hypoxia and Ischemia Research (CHaIR) |
| Thomas Evans |
Molecular and cellular mechanisms of early embryonic development in C. elegans using genetic and biochemical approaches |
| Thomas Finger |
Development and organization of taste and smell |
| Joan Hooper |
Cell determination, developmental patterning and hedgehog signaling in drosophila |
| Kathryn Howell |
Structure/function of the Golgi complex using mass spectrometry, proteomics, functional assays, and high resolution 3D structure |
| John Hutton |
Secretory granule biogenesis and exocytosis in the endocrine pancreas: role in human diabetes |
| Karen King |
Cellular response to mechanical loading in skeletal tissues |
| Peter Koch |
Cell adhesion molecules in embryonic development and diseases |
| Wendy Macklin |
Oligodendrocyte development and disease |
| Jim McManaman |
Mammary gland development and function |
| Karl Pfenninger |
Regulation of pseudopod attachment in nerve growth cones/cancer cells |
| Rytis Prekeris |
Molecular mechanisms regulating the establishment and maintenance of cellular polarity in epithelial cells and neurons |
| Yosef Refaeli |
The role of MYC in the regulation of hematopoietic stem cell self-renewal, proliferation, differentiation and survival |
| Diego Restrepo |
Olfactory signal transduction and olfactory sensory coding using electrophysiological, morphological and molecular techniques |
| Jane Reusch |
Function of the CREB transcription factor in cellular homeostasis, and the relationship between CREB dysfunction and the complications of diabetes |
| Mary Reyland |
Role of protein kinase C delta signaling in apoptosis and cancer |
| Sue Reynolds |
Lung stem cell function: roles for Wnt signaling |
| Pepper Schedin |
Stromal-epithelial interactions in mammary gland development, carcinogenesis and breast cancer prevention |
| Geeta Sharma |
Mechanisms of synaptic plasticity |
| Xiao-Jing Wang |
TGFbeta signaling in cancer and skin development |
| Virginia Winn |
Human Placental Development, Preeclampsia Pathogenesis |
Stem Cells
Stem Cell Biology Research offers enormous therapeutic potential for a wide range of clinical disorders including Parkinson's disease, diabetes, chronic heart disease, end-stage renal disease, liver failure and cancer. Realizing the promise of using stem cells in treating human disease will ultimately depend upon defining the cellular and molecular mechanisms that regulate cell proliferation and differentiation. These fundamental principles are at the heart of modern Cell Biology, Stem Cells and Development and highlight the dynamic interdisciplinary work being undertaken by the faculty and graduate students in the Cell Biology, Stem Cells and Development Graduate Program at the University of Colorado Anschutz Medical Campus.
| Bruce Appel |
Development and repair of the vertebrate nervous system |
| Kristin Artinger |
Molecular, genetic and developmental mechanisms involved in the patterning of the early spinal cord (neural plate) during vertebrate embryogenesis |
| Vivek Balasubraniam |
Pulmonary development and injury |
| Linda Barlow |
Developmental neurobiology; patterning and formation of sensory organs |
| Thomas Evans |
Molecular and cellular mechanisms of early embryonic development in C. elegans using genetic and biochemical approaches |
| Jim Hagman |
Regulation of B lymphocyte - specific transcription and differentiation |
| Karen King |
Cellular response to mechanical loading in skeletal tissues |
| Peter Koch |
Cell adhesion molecules in embryonic development and diseases |
| Maranke Koster |
Signaling pathways that control epidermal development and differentiation |
| Karl Pfenninger |
Regulation of pseudopod attachment in nerve growth cones/cancer cells |
| Yosef Refaeli |
The role of MYC in the regulation of hematopoietic stem cell self-renewal, proliferation, differentiation and survival |
| Sue Reynolds |
Lung stem cell function: roles for Wnt signaling |
| Dennis Roop |
Skin development and disease |
| Geeta Sharma |
Mechanisms of synaptic plasticity |
| Xiao-Jing Wang |
TGFbeta signaling in cancer and skin development |
| Trevor Williams |
Transcriptional regulation of mouse embryonic development and the role of transcription factors in mammary gland development and breast cancer |
Development
All animals begin life as a single cell, the result of a fusion between sperm and egg. Through a staggering multitude of molecular, cellular and tissue level events, a properly organized, multicellular embryo is formed. In the last decade, our understanding of many of these processes has expanded dramatically due to the advent of cellular, molecular biological and genetic approaches. Intriguingly, many of these processes first recognized in developmental contexts have also been implicated in human disease. These types of fundamental studies form the core of cutting edge research in Developmental Biology by faculty of the Graduate Program in Cell Biology, Stem Cells and Development at the University of Colorado Anschutz Medical Campus.
| Bruce Appel |
Development and repair of the vertebrate nervous system |
| Kristin Artinger |
Molecular, genetic and developmental mechanisms involved in the patterning of the early spinal cord (neural plate) during vertebrate embryogenesis |
| Vivek Balasubraniam |
Pulmonary development and injury |
| Linda Barlow |
Developmental neurobiology; patterning and formation of sensory organs |
| Steve Britt |
Visual system development and function using molecular/genetic approaches in Drosophila |
| John Caldwell |
Functional regulation of ion channels in plasma membranes and Golgi membranes using electrophysiology and molecular biology |
| David Clouthier |
Signaling pathways regulating craniofacial and cardiovascular development |
| Stijn DeLanghe |
Lung development and regeneration |
| Thomas Evans |
Molecular and cellular mechanisms of early embryonic development in C. elegans using genetic and biochemical approaches |
| Thomas Finger |
Development and organization of taste and smell |
| Jim Hagman |
Regulation of B lymphocyte - specific transcription and differentiation |
| Joan Hooper |
Cell determination, developmental patterning and hedgehog signaling in drosophila |
| Peter Koch |
Cell adhesion molecules in embryonic development and diseases |
| Maranke Koster |
Signaling pathways that control epidermal development and differentiation |
| Wendy Macklin |
Oligodendrocyte development and disease |
| Jim McManaman |
Mammary gland development and function |
| Lee Niswander |
Genetic mechanisms of limb, lung, and neural development |
| Karl Pfenninger |
Regulation of pseudopod attachment in nerve growth cones/cancer cells |
| Rytis Prekeris |
Molecular mechanisms regulating the establishment and maintenance of cellular polarity in epithelial cells and neurons |
| Sue Reynolds |
Lung stem cell function: roles for Wnt signaling |
| Dennis Roop |
Skin development and disease |
| Pepper Schedin |
Stromal-epithelial interactions in mammary gland development, carcinogenesis and breast cancer prevention |
| Xiao-Jing Wang |
TGFbeta signaling in cancer and skin development |
| Trevor Williams |
Transcriptional regulation of mouse embryonic development and the role of transcription factors in mammary gland development and breast cancer |
| Virginia Winn |
Human Placental Development, Preeclampsia Pathogenesis |