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Down syndrome,
or Trisomy 21, is:

  • A condition whereby there are three copies of the 21st chromosome instead of two.
  • One of the leading clinical causes of cognitive delay in the world.
  • The most frequently occurring chromosomal condition, affecting approximately 1 in every 733 births in the United States.

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Linda Crnic Institute for Down Syndrome

Edward McCabe Letter from the Executive Director About two years ago, I assumed the position of Executive Director of the Linda Crnic Institute for Down Syndrome, having completed a second term as Chair of Molecular, Cellular and Developmental Biology at the University of Colorado, Boulder. Before I came to Boulder, I was Chair of Biochemistry and Molecular Genetics at the University of Colorado Health Sciences Center for eight years, and before that Chair of Biological Sciences at Indiana University, Bloomington, for many years.  While I am no stranger to either academic administration or to the Health Sciences Center, I am relatively new to studying Down syndrome. I have spent most of my scientific career doing basic research, primarily on various aspects of gene expression and on the arrangement of genes on chromosomes. Nonetheless, I feel I am in a unique position to lead the Crnic Institute in its effort to eradicate the medical and cognitive ill effects associated with Down syndrome.    Read more >>

Linda Crnic and 9News - Kyle Dyer

Linda Crnic Annual Down Syndrome Symposium

Friday, October 31, 2014
10:00 a.m. - 2:30 p.m.
Research 1, Hensel Phelps Auditorium/Atrium West, P18-1006
Anschutz Medical Campus

Be Beautiful Be Yourself Fashion Show

Saturday, October 25, 2014
Sheraton Downtown Denver Hotel Presented by Global Down Syndrome Foundation



Anna Sie
Co-Founder of the Anna and John J. Sie Foundation

John Sie
Founder and Former Chairman of Starz Entertainment Group LLC (SEG)

Michelle Sie Whitten
Executive Director of the Anna and John J. Sie Foundation

Anna and John J. Sie Foundation

Global Down Syndrome Foundation

Tom Blumenthal, PhD
Executive Director

Linda Crnic Institute for Down Syndrome
Research Complex 2
Room P15-4014
Mail Stop 8608
12700 E 19th Ave.
Aurora, CO 80045
Phone: 303-724-6599
Fax: 303-724-5741

SIE Center for Down Syndrome
Children’s Hospital Colorado
For Appointments Please Call: 720-777-6750