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Grand Challenge Grant Program Requirements


  • Investigators must hold the rank of Assistant Professor, Research Assistant Professor, Instructor, or higher. Adjunct and Clinical faculty are eligible but must name a PI with regular faculty rank.
  • Applicant must have attended the Crnic Down Syndrome Symposium on Wednesday, September 26, 2018. Register Now!
  • Applicant must have replied to the email of intent sent out by Joaquin Espinosa.
  • The application must be relevant to Down syndrome or one of its associated conditions.
  • The most successful applications will be those that directly address one or more of the “Major Challenges.”
  • Direct relevance of the proposals to Down syndrome is paramount.

Recipient Requirements

Those receiving a Crnic Grand Challenge Grant will be expected to become active members of the University of Colorado Down syndrome research community. Recipients will:

  • participate, along with the lab members working on the research project, in the Crnic Supergroup meetings
  • self-identify as a member of Crnic (in addition to their home department) on all publications emanating from the work resulting from this grant.
  • use these funds solely to support the research described in their proposal.
  • provide an annual report by March 19, 2020.
  • present a report at a future Down Syndrome Symposium hosted by Crnic.
  • understand that no indirect costs will be provided.

Application Requirements

All Crnic Grand Challenge Grant applications are to be submitted no later than January 9, 2019, and should include the following elements:

  1. a brief cover note from the PI describing the value of the project, and the expected contribution to the community of Down syndrome researchers, and a statement that all collaborators listed on the application agree with the proposal.
  2. a proposal body consisting of no more than five pages including figures (if any) in standard NIH grant application format. Recommended, but not required, guidelines for proposals include: specific aims, background and broader impact, and research plan. Preliminary results are not required but should be included if they exist. (References are not included in the five-page limit).
  3. explanatory figures and data figures are acceptable, as are a limited number of references.
  4. a one-page budget proposal, enumerating direct costs. Please use the budget template provided on the Crnic Grand Challenge Grants Program webpage at:
  5. NIH formatted Biosketch for the PI or PIs.

Please note that parts 1, 2 and 3 should be combined into a single PDF document. Parts 4 and 5 should each be an individual PDF file. These three PDF documents are to be submitted online at:

To be eligible, an email of intent to apply needs to be sent to​ by Tuesday, November 6, 2018.

After your application submission is complete, you will receive a confirmation by email.

Please contact if you have problems with your online submission.