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Title

Pancreatic islet electrical dysregulation in Type 1 diabetes and Type 2 diabetes

Project Description

Diabetes involves death or dysfunction to insulin secreting beta cells in the islets of Langerhans of the pancreas. We seek to understand the molecular mechanisms how electrical dysregulation within beta cells occurs early in the progression of type1 and type2 diabetes pathogenesis, and how this dysregulation contributes to altered insulin secretion and beta cell viability. Using both mouse models of diabetes and primary human tissue, we utilize live cell imaging and optogenetic approaches to probe specific signalling pathways underlying insulin secretion. We also utilize these approaches to discover novel cell sub-populations which may direct overall islet function and may decline early in diabetes pathogenesis.

Area of Study

Metabolism and Endocrinology; Pharmacology and Physiology

Populations

Health Disparities

Method

Animal Models; Cell Biology, Molecular Biology, and Genetics; Imaging

Disease or Symptom

Diabetes

Department

Physiology and Biophysics

Mentor Location

Barbara Davis Center/AMC

Mentor Contact Number

3037246388

Mentor Email

richard.benninger@ucdenver.edu

Website

 

Mentor Name

Benninger, Richard

Funding Department/Program

Barbara Davis Center

Status

Current

Display on public listing?

Yes

Upload Date

 

Attachments

Created at 8/5/2018 10:05 AM by Hom, Patrick H
Last modified at 8/5/2018 12:11 PM by Hom, Patrick H