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Title

Gene expression control in cancer and trisomy 21

Project Description

Our main research goal is to understand how gene networks control cell behavior. Cancer is our core paradigm, but our discoveries often lead us into other areas of biology. We define cancer as a disease of gene networks gone awry. Our research focuses on the molecular mechanisms by which cancer-relevant genes regulate the networks in which they are embedded. We believe that this type of basic research is a requisite step in the development of effective cancer therapeutics. This field is broad with many important questions, which inspires us to constantly expand our repertoire of approaches and technologies to find answers.
Much of our research enterprise focuses on the p53 gene network. p53 is the most commonly mutated gene in human cancer and our research may enable effective cancer therapies. We also study other cancer genes, such as the oncogenes CDK8, HIF1A and p63.
More recently, we started to investigate the molecular, cellular and organismal effects of trisomy 21, the genetic condition that causes Down syndrome. In particular, we are interested in elucidating how trisomy 21 causes a different disease spectrum in the population with Down syndrome, protecting these individuals from some conditions (e.g. solid tumors) while predisposing them to others (e.g. Alzheimer's disease).

Area of Study

Developmental Neuroscience, Brain and Behavior - child; Hematology and Oncology

Populations

 

Method

Animal Models; Biomolecular Structure and Biochemistry; Cell Biology, Molecular Biology, and Genetics

Disease or Symptom

Cancer; Downs Syndrome; Mental Illness and Developmental Disabilities

Department

Pharmacology

Mentor Location

 

Mentor Contact Number

 

Mentor Email

joaquin.espinosa@ucdenver.edu

Website

 

Mentor Name

Espinosa, Joaquin

Funding Department/Program

Cancer Center

Status

Current

Display on public listing?

Yes

Upload Date

 

Attachments

Created at 5/12/2016 7:13 AM by Ross, Randy
Last modified at 8/14/2019 12:43 PM by Zoghby, Caitlin