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Title

Influence of the microbiota on the development of systemic autoimmunity

Project Description

​Dr. Kuhn’s general lab hypothesis is centered upon understanding how impairment in the mucosal barrier in combination with defects in immune regulation can lead to systemic autoimmune disease. Currently Dr. Kuhn and her team are evaluating how epithelial T cells (IELs) respond to resident bacteria and contribute to the epithelial barrier of the intestine; and are investigating bacterially-driven trafficking of immune cells out of the colon to distant tissues with a focus on the development of extra-intestinal Crohn’s disease; and how microbial dysbiosis results in autoreactive B cell development in Rheumatoid arthritis..

Area of Study

Immunology and Autoimmune Diseases

Populations

 

Method

Animal Models; Cell Biology, Molecular Biology, and Genetics; Light Microscopy

Disease or Symptom

Gastrointestinal Disease; Immune Related Disease

Department

Medicine

Mentor Location

Mail Stop B115

Mentor Contact Number

303-724-8258

Mentor Email

kristine.kuhn@ucdenver.edu

Website

http://www.ucdenver.edu/academics/colleges/medicalschool/departments/medicine/Rheumatology/faculty/Pages/KristineKuhn.aspx

Mentor Name

Kuhn, Kristine

Funding Department/Program

Medicine

Status

Current

Display on public listing?

Yes

Upload Date

 

Attachments

Created at 3/19/2016 10:14 AM by Ross, Randy
Last modified at 8/14/2019 12:51 PM by Zoghby, Caitlin