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Title

Role of EphB4 of radiosensitization of head and neck cancer

Project Description

Dr. Karam’s laboratory is focused on basic and translational research related to head and neck cancer.  We use molecular, cellular, and preclinical animal models to understand mechanisms of tumor response to radiation treatment. With the goal of developing novel therapeutics we study how targeting members of the Eph gene family, the largest family of receptor tyrosine kinases, enhances tumor radiosensitization while limiting radiation toxicity to normal tissue. Our goal is to open IRB approved clinical trials to translate the research findings to patients with aggressive head and neck cancer.

Area of Study

Hematology and Oncology

Populations

 

Method

Animal Models; Cell Biology, Molecular Biology, and Genetics

Disease or Symptom

Cancer

Department

Radiation Oncology

Mentor Location

 

Mentor Contact Number

703-965-6506

Mentor Email

sana.karam@ucdenver.edu

Website

http://www.ucdenver.edu/academics/colleges/medicalschool/departments/radiationoncology/Research/Pages/LabResearch.aspx

Mentor Name

Karam, Sara

Funding Department/Program

Cancer Center

Status

Current

Display on public listing?

Yes

Upload Date

 

Attachments

Created at 11/13/2015 12:06 PM by Ross, Randy
Last modified at 8/14/2019 12:49 PM by Zoghby, Caitlin