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Title

Neural mechanisms of cross-sensistization in the pelvis and chronic pelvic pain

Project Description

Chronic pelvic pain (CPP) is a common symptom of many urologic and gastrointestinal disorders including interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS). Our group was at the forefront of the research efforts aimed at understanding the mechanisms underlying co-morbid CPP disorders and provided initial evidence that cross-sensitization via neural pathways triggers the development of neurogenic inflammation in the pelvis and chronic pelvic pain of unknown etiology. We determined that transient colonic inflammation causes neurogenic bladder dysfunction evaluated by cystometry, triggers hyperexcitability of bladder sensory and spinal neurons, increases pro-inflammatory neuropeptides in the bladder, and alters detrusor contractility.

Area of Study

Neuroscience, Brain and Behavior - Adult; Pharmacology and Physiology; Surgery

Populations

Adults

Method

Animal Models; Behavioral; Electrophysiology; Imaging; Surveys, Questionnaires, and Psychological Testing

Disease or Symptom

Kidney, Bladder, and Urethral Disease; Multiple Sclerosis; Stress

Department

Surgery

Mentor Location

12700 E 19th Ave, Rm 6001

Mentor Contact Number

(303) 724-6300

Mentor Email

anna.malykhina@ucdenver.edu

Website

http://www.ucdenver.edu/academics/colleges/medicalschool/departments/surgery/divisions/urology/Research/Pages/Welcome.aspx

Mentor Name

Malykhina, Anna

Funding Department/Program

Surgery

Status

Current

Display on public listing?

Yes

Upload Date

8/25/2015 3:25 PM

Attachments

Created at 8/26/2015 4:12 PM by Ross, Randy
Last modified at 5/7/2016 1:37 PM by Ross, Randy