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Title

Lung Vascular Development and Neonatal Pulmonary Hypertension

Project Description

The Pediatric Heart Lung Center is an interdisciplinary research group that primarily studies mechanisms underlying normal lung vascular development and how disruption of this process contributes to neonatal lung and cardiovascular disorders, especially pulmonary hypertension and lung hypoplasia.  Animal models include approaches to better understand antenatal causes of lung disease, such as preeclampsia and chorioamnionitis, in rats and mice.  Physiologic, histologic and morphometric approaches are used to quantify changes in lung structure and function. Additional studies involve endothelial cell studies in vitro, as well as molecular and biochemical strategies for investigating basic mechanisms of disease.  Ongoing projects are exploring the roles of enhancing endothelial function to prevent pulmonary vascular disease in the fetus and newborn, including novel pharmacologic agents and other strategies.

Area of Study

Pulmonary and Critical Care

Populations

Infants

Method

Animal Models

Disease or Symptom

Lung Disease

Department

Pediatrics

Mentor Location

Children's Hospital Colorado

Mentor Contact Number

720-724-5821

Mentor Email

steven.abman@ucdenver.edu

Website

 

Mentor Name

Abman, Steven H.

Funding Department/Program

Pediatrics

Status

Current

Display on public listing?

Yes

Upload Date

8/15/2015 4:01 PM

Attachments

Created at 8/20/2015 10:14 AM by Miller, Michael
Last modified at 5/7/2016 4:02 PM by Ross, Randy