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Title

Mechanisms of impaired fetoplacental aniogenesis in fetal growth restriction

Project Description

In pregnancies complicated by severe fetal growth restriction secondary to placental insufficiency, the only option that obstetricians have is to proceed with delivery, oftentimes quite prematurely, in order to avert stillbirth.  Existing clinical data, however, suggests that timing of delivery and existing ultrasound parameters do not substantially affect survival or long-term outcome.  Thus, understanding the mechanisms underlying placental insufficiency and fetal growth restriction are needed if we are to be able to actually improve outcomes.  Clinical data also demonstrate that fetuses/placentas that demonstrate abnormal blood flow, (e.g. abnormal umbilical artery Doppler waveforms), are the ones that suffer the worst outcomes. Morphometric studies have shown that these placentas do not form a proper vascular tree, and much of the defective angiogenesis is purported to occur in later pregnancy. Thus, the goal of this project is to determine mechanisms underlying impaired fetoplacental angiogenesis in human fetoplacental endothelial cell models.  

Area of Study

Child-Maternal Health and Reproductive Sciences

Populations

Pregnant Women

Method

Cell Biology, Molecular Biology, and Genetics

Disease or Symptom

Pregnancy

Department

Obstetrics and Gynecology

Mentor Location

Research Complex 2 12700 E. 19th Avenue

Mentor Contact Number

303-724-9227

Mentor Email

emily.su@ucdenver.edu

Website

 

Mentor Name

Su, Emily

Funding Department/Program

Obstetrics and Gynecology

Status

Current

Display on public listing?

Yes

Upload Date

 

Attachments

Created at 8/20/2015 10:14 AM by Miller, Michael
Last modified at 8/14/2019 1:07 PM by Zoghby, Caitlin