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Title

High Resolution Imaging of Lipids in the Brain

Project Description

The brain is largely composed of lipid, hence lipid homeostasis in the brain is tightly regulated and critical for optimal function.  Dysregulated lipid metabolism in the brain is associated with a number of cognitive and neurodegenerative disorders. However the basic mechanisms underlying lipid trafficking and metabolism are unclear.  In our lab we are using stably transfected hypothalamic neuronal cell lines that express varying levels of Lipoprotein Lipase (LPL), in combination with cutting-edge Third harmonic Imaging techniques, to identify changes in the intracellular sites of lipid deposition that correlate with human disease.  

Area of Study

Neuroscience, Brain and Behavior - Adult

Populations

 

Method

Cell Biology, Molecular Biology, and Genetics; Imaging

Disease or Symptom

Neurological Illness

Department

Medicine

Mentor Location

 

Mentor Contact Number

 

Mentor Email

Robert.Eckel@ucdenver.edu

Website

http://www.ucdenver.edu/academics/colleges/medicalschool/departments/medicine/EndocrinologyMetabolismDiabetes/faculty_staff/Pages/Eckel.aspx

Mentor Name

Eckel, Robert

Funding Department/Program

Medicine

Status

Current

Display on public listing?

Yes

Upload Date

7/31/2015 3:52 PM

Attachments

Created at 8/20/2015 10:14 AM by Miller, Michael
Last modified at 5/18/2016 7:54 AM by Ross, Randy