Human papillomaviruses (HPVs) are highly prevalent and potent pathogens causally associated with over 5% of all human cancers, including ~25% of head and neck cancers. While a majority of people becomes infected with HPV, most clear their infections and, of the remaining people with persistent infections, only small fractions develop pre-cancerous lesions and invasive cancers. Our research focuses on understanding how HPV interacts with the host factors to establish persistent infection and develop invasive cancers. We have recently revealed virus-induced cancer immune evasion that contributes to cancer progression. To better understand the underlying mechanisms of HPV-induced suppression of antitumor immune responses, we are investigating chemokine expression and regulation in the tumor microenvironment with persistent HPV infection, using in vitro cell culture systems, in vivo mouse models, and human patient specimens.