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Title

Virus-induced Immune Dysregulation in HPV-associated Head and Neck Cancer

Project Description

Human papillomaviruses (HPVs) are highly prevalent and potent pathogens causally associated with over 5% of all human cancers, including ~25% of head and neck cancers. While a majority of people becomes infected with HPV, most clear their infections and, of the remaining people with persistent infections, only small fractions develop pre-cancerous lesions and invasive cancers. Our research focuses on understanding how HPV interacts with the host factors to establish persistent infection and develop invasive cancers. We have recently revealed virus-induced cancer immune evasion that contributes to cancer progression. To better understand the underlying mechanisms of HPV-induced suppression of antitumor immune responses, we are investigating chemokine expression and regulation in the tumor microenvironment with persistent HPV infection, using in vitro cell culture systems, in vivo mouse models, and human patient specimens.

Area of Study

Hematology and Oncology

Populations

Adults

Method

Animal Models; Cell Biology, Molecular Biology, and Genetics; Light Microscopy

Disease or Symptom

Cancer; Infection

Department

Immunology and Microbiology

Mentor Location

12800 E. 19th Ave.

Mentor Contact Number

303-724-7279

Mentor Email

dohun.pyeon@ucdenver.edu

Website

http://www.ucdenver.edu/academics/colleges/medicalschool/departments/ImmunologyMicrobiology/faculty/departmental/Pages/PYEON.aspx

Mentor Name

Pyeon, Dohun

Funding Department/Program

Cancer Center

Status

Current

Display on public listing?

Yes

Upload Date

 

Attachments

Created at 8/20/2015 10:14 AM by Miller, Michael
Last modified at 8/14/2019 1:02 PM by Zoghby, Caitlin