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Title

Varicella latency and reactivation in an animal model

Status

Open

Project Description

Because varicella zoster virus (VZV) is an exclusively human pathogen, the development of an animal model is necessary to study pathogenesis, latency and reactivation. The pathological, virological and immunological features of simian varicella virus (SVV) infection in nonhuman primates are similar to those of VZV infection in humans.  Both natural infection of cynomolgus and African green monkeys as well as intrabronchial inoculation of rhesus macaques with SVV provide the most useful models to study viral and immunological aspects of latency and the host immune response.  Experimental immunosuppression of monkeys latently infected with SVV results in zoster, thus providing a new model system to study how the loss of adaptive immunity modulates virus reactivation.

Mentor Name

Mahalingam, Ravi

Mentor Location

12700 East 19th Avenue

Mentor Contact Number

303-724-4324

Mentor Contact Email

ravi.mahalingam@ucdenver.edu

Specialty

Enter Choice #1

Preceptor Name

 

Student

 

Department

Neurology

Funding Department/Program

Neurology

Area of Study

Health Care and Public Health Research; Immunology and Autoimmune Diseases

Populations

 

Method(s)

Animal Models; Cell Biology, Molecular Biology, and Genetics; Light Microscopy

Disease or Symptom

Infection

Faculty/Lab Website

http://www.ucdenver.edu/academics/colleges/medicalschool/departments/neurology/Faculty/Pages/Mahalingam.aspx

Display on public listings?

Yes

Attachments

Created at 6/17/2011 10:18 AM by Vetter, Stephanie
Last modified at 7/9/2013 1:56 PM by Watts, Katie