Research Track

Our lab studies signaling and transcriptional regulation of allergic immune responses.  We study three major allergic effector cells: T helper type 2 cells, basophils and eosinophils.  One of the problem we are working on is how Th2 immune responses are initiated in vivo in response to allergen challenge.  In this project, we use an interleukin 4 (the major cytokine in initiating allergic immune response) green fluorescence protein reporter mice to identify cells that produce IL-4 in response to various types of allergens.  Understanding of how allergic immune responses are initiated will help develop treatment for preventing and treating allergic diseases and asthma.