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Title

Epigenetics and Asthma

Status

Open

Project Description

The overall goal of this project is to understand how epigenetic mechanisms alter immune regulation and contribute to the etiology of allergic airway disease.  Epigenetic mechanisms, as a cause of asthma, build on our current knowledge about the etiology of asthma (non-Mendelian and parent-of-origin pattern of inheritance, environment, in utero exposures, and the importance of dendritic cells and Th2 immunity) and provide an entirely novel paradigm for this disease. Our recent work in mice demonstrates that in utero diet can have an impact on CpG methylation, Th2 skewing, and trans-generational inheritance of allergic airway disease.  Two subsequent independent epidemiological studies have demonstrated that in utero exposure to folate (a methylating agent) is associated with the risk of developing asthma in humans.  We are currently pursuing research in both humans and mice to understand the role of epigenetic marks in the development of asthma.

Mentor Name

Schwartz, David A.

Mentor Location

12631 East 17th Avenue, B178, Aurora, CO  80045

Mentor Contact Number

303-724-1783

Mentor Contact Email

david.schwartz@ucdenver.edu

Specialty

Enter Choice #1

Preceptor Name

 

Student

 

Department

Medicine

Funding Department/Program

Medicine

Area of Study

Pulmonary and Critical Care

Populations

 

Method(s)

Animal Models; Cell Biology, Molecular Biology, and Genetics; Clinical Trials

Disease or Symptom

Asthma; Lung Disease

Faculty/Lab Website

http://www.nationaljewish.org/cgeh

Display on public listings?

Yes

Attachments

Created at 6/17/2011 9:25 AM by Vetter, Stephanie
Last modified at 7/9/2013 1:53 PM by Watts, Katie