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Title

Mucosal Defense Against Infection

Status

Open

Project Description

The goal of our laboratory is to provide a scientific foundation for mucosal vaccines to prevent pneumococcal and influenza infections in the lung and transmission of HIV-1 in the intestine, reproductive tract and by breast milk.  We integrate clinical and basic laboratory approaches to determine how pathogens interact with the host at the mucosal surface and how innate and humoral mechanisms, individually and in concert, serve to protect against infection.  Our primary model for mucosal defense against HIV involves post-natal transmission of the virus by breast milk.  We characterize mechanisms by which pathogen- specific antibodies in blood and milk from transmitting and non-transmitting mothers in Uganda neutralize autologous and heterlogous HIV isolates using cellular, molecular, and biochemical approaches.  For S. pneumoniae and influenza, we characterize systemic and mucosal responses to natural infection and vaccine, the molecular basis for capsule-specific antibody responses, and the functional activity of these human antibodies.  The goal is to develop effective vaccines against these pathogens to prevent infections where they begin, at the mucosa.

Mentor Name

Janoff, Edward M.

Mentor Location

Research Tower II - 11th floor

Mentor Contact Number

303-724-4936

Mentor Contact Email

Edward.janoff@ucdenver.edu

Specialty

Enter Choice #1

Preceptor Name

 

Student

 

Department

Medicine

Funding Department/Program

Medicine

Area of Study

Microbiology and Infectious Diseases

Populations

Infants

Method(s)

Animal Models; Cell Biology, Molecular Biology, and Genetics

Disease or Symptom

Infection

Faculty/Lab Website

http://www.ucdenver.edu/academics/colleges/medicalschool/departments/medicine/InfectiousDiseases/idfaculty/Pages/EdwardNJanoffMD.aspx

Display on public listings?

Yes

Attachments

Created at 6/17/2011 8:57 AM by Vetter, Stephanie
Last modified at 7/9/2013 1:51 PM by Watts, Katie