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Title

The role of innate immune system in kidney disease

Status

Open

Project Description

Injury of the kidney can also activate the body’s own immune system, and the resulting inflammatory response plays a critical role in the overall outcome.  There is an ‘innate’ immune response that we all muster when we are exposed to bacteria and viruses.  Under these conditions this system is highly protective.  However, this system can also be activated when the kidney is injured, such as following prolonged cardiac bypass surgery. Under these conditions the development of an inflammatory response may do more harm than good. My laboratory is actively searching to identify the pathways by which the innate immune system is triggered in kidney disease.  We are also testing and developing new therapies to block specific parts of the immune system. It is our hope that some of the new drugs being developed will one day hit the clinic and have an impact on the ever increasing burden of kidney disease the Nation is facing.

Mentor Name

Thurman, Joshua M.

Mentor Location

1775 Aurora Ct, Mail stop B-115

Mentor Contact Number

303-724-7584

Mentor Contact Email

Joshua.thurman@ucdenver.edu

Specialty

Enter Choice #1

Preceptor Name

 

Student

 

Department

Medicine

Funding Department/Program

Rheumatology Grant

Area of Study

Immunology and Autoimmune Diseases

Populations

 

Method(s)

Hormonal

Disease or Symptom

Kidney Disease

Faculty/Lab Website

 

Display on public listings?

Yes

Attachments

Created at 7/14/2010 9:45 PM by Macfarlane, Helen
Last modified at 8/7/2012 12:58 PM by Watts, Katie