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Title

Role of TGF beta signaling in HNSCC progression

Status

Open

Project Description

Head and neck squamous cell carcinoma (HNSCC) is the most common cancer in the head and neck region. Despite advances in surgery and chemotherapy, HNSCC has the lowest five-year survival rate among major cancers. TGFβ is a multifunctional cytokine. TGFβ suppresses tumor formation. Paradoxically, it also promotes cancer metastasis. We are using conditional transgenic/knockout mouse models to alter individual TGFb1 signaling components in head and neck epithelia and skin epidermis, in order to determine the mechanisms of TGFβ effects on cancer, including TGFβ signaling through pathways of Smad, MAPK, Rho, etc.
 

Mentor Name

Wang, Xiao-Jing

Mentor Location

RC1-N, Room P18-5128

Mentor Contact Number

303-724-3001

Mentor Contact Email

XJ.Wang@ucdenver.edu

Specialty

Enter Choice #1

Preceptor Name

 

Student

 

Department

Pathology

Funding Department/Program

Pathology

Area of Study

Hematology and Oncology

Populations

 

Method(s)

Animal Models; Cell Biology, Molecular Biology, and Genetics

Disease or Symptom

Cancer

Faculty/Lab Website

http://www.ucdenver.edu/academics/colleges/medicalschool/departments/Pathology/aboutus/faculty/Pages/wang_x.aspx

Display on public listings?

Yes

Attachments

Created at 11/15/2010 11:21 AM by Vetter, Stephanie
Last modified at 11/14/2014 7:13 AM by Miller, Cody