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Title

Influences of Cholesterol and Statins in Ovarian Cancer Chemosensitivity

Status

Open

Project Description

The Behbakht lab in association with collaborators has been studying the effects of cholesterol and statins on the response to ovarian cancer chemotherapy for the last 3 years.  Reports of improved clinical response to platinum agents in ovarian cancer patient who are concurrently on statins prompted the generation of ex-vivo models to study this effect.  The interactions are complex and may involve signaling through the EGFR pathway and sequestration in collagen rafts.  The hypothesis is that elevated cholesterol interferes with platinum sensitivity and statins reverse this effect.  This is a unique way to study the primary tumor in its microenvironment without using mouse models.

Mentor Name

Behbakht, Kian

Mentor Location

Academic Office One - Room 4413

Mentor Contact Number

303-724-3522

Mentor Contact Email

kian.behbakht@ucdenver.edu

Specialty

Enter Choice #1

Preceptor Name

 

Student

 

Department

Obstetrics and Gynecology

Funding Department/Program

Obstetrics and Gynecology

Area of Study

Hematology and Oncology

Populations

Women

Method(s)

Cell Biology, Molecular Biology, and Genetics

Disease or Symptom

Cancer

Faculty/Lab Website

 

Display on public listings?

Yes

Attachments

Created at 10/5/2010 2:20 PM by Vetter, Stephanie
Last modified at 10/31/2014 2:24 PM by Miller, Cody