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SOM Research Projects: Zebrafish as a model to investigate developmental disorders of the nervous system

Title

Zebrafish as a model to investigate developmental disorders of the nervous system

Status

Open

Project Description

Periventricular white matter injury is the most common cause of brain injury in preterm infants and results in long term developmental disabilities. Oligodendrocytes, the glial cells that produce the myelin, or white matter of the brain, seem to be particularly susceptible to various insults such as hypoxia during fetal development. We are working to establish zebrafish as a new model system to investigate the molecular mechanisms that mediate white matter injury in response to hypoxia and to test strategies designed to promote regeneration.
 
Other projects are available to investigate mechanisms that maintain and specify neural precursor and stem cells and that regulate migration, proliferation and differentiation of glial cells.

Mentor Name

Appel, Bruce

Mentor Location

RC1 South, 12115

Mentor Contact Number

303-724-3465

Mentor Contact Email

bruce.appel@ucdenver.edu

Specialty

Enter Choice #1

Preceptor Name

 

Student

 

Department

Pediatrics

Funding Department/Program

Pediatrics

Area of Study

Developmental Neuroscience, Brain and Behavior - Child

Populations

Infants

Method(s)

Animal Models

Disease or Symptom

Basic Human Processes; Mental Illness and Developmental Disabilities; Neurological Illness

Faculty/Lab Website

http://www.ucdenver.edu/academics/colleges/medicalschool/programs/CSD/People/Faculty/Pages/Appel,%20Bruce.aspx

Display on public listings?

No

Attachments

Created at 9/2/2010 2:22 PM by Vetter, Stephanie
Last modified at 12/7/2012 12:28 PM by Watts, Katie