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Title

Novel Therapeutics for Gastrointestinal Cancers

Status

Open

Project Description

Our lab (Arcaroli/Messersmith) aims to translate benchtop findings from cancer cell lines/animal models into clinical trials with the overarching goal of developing better treatment for gastrointestinal cancers.  We focus on colorectal and pancreas cancer, with a therapeutic strategy of blocking signal transduction pathways that cancer cells use to grow, spread, produce blood vessels, etc.  We also analyze human samples from clinical trials in order to directly test the hypotheses developed in the laboratory.  We have a special interest in directly targeting cancer stem calls.  Finally, we work on combining anti-cancer drugs in a rational manner based on solid laboratory data.  Current signal transduction pathways under study include Src, Notch, and Hedgehog.

Mentor Name

Messersmith, Wells and Arcaroli, John

Mentor Location

RC-1 South, Room 8126

Mentor Contact Number

303-724-3808

Mentor Contact Email

wells.messersmith@ucdenver.edu

Specialty

Enter Choice #1

Preceptor Name

 

Student

 

Department

Medicine

Funding Department/Program

Medicine

Area of Study

Hematology and Oncology

Populations

 

Method(s)

Animal Models; Cell Biology, Molecular Biology, and Genetics; Clinical Trials; Treatment Trials

Disease or Symptom

Cancer; Gastrointestinal Disease

Faculty/Lab Website

http://ucdenver.edu/academics/colleges/medicalschool/departments/medicine/MedicalOncology

Display on public listings?

Yes

Attachments

Created at 7/29/2010 3:28 PM by Vetter, Stephanie
Last modified at 7/9/2013 1:52 PM by Watts, Katie