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Title

Novel Gene Discovery in Sepsis and Host Defense

Status

Open

Project Description

The overall goals of this research project are to identify novel genes involved in innate immunity and to determine if polymorphisms in some of these genes regulate the innate immune response to lipopolysaccharide (LPS) in humans.  The overall hypothesis of this line of investigation is that polymorphisms of genes identified either by gene expression profiling or by positional cloning in phenotypically distinct strains of mice following airway or systemic challenge with LPS regulate the pathophysiologic response to LPS in humans.  C. elegans and RNAi are used to test the physiologic and biologic importance of these novel genes.

Mentor Name

Schwartz, David A.

Mentor Location

National Jewish Health; 1400 Jackson Street; Smith Building (A648); Denver

Mentor Contact Number

303-398-1903

Mentor Contact Email

schwartzd@njhealth.org

Specialty

Enter Choice #1

Preceptor Name

 

Student

 

Department

Medicine

Funding Department/Program

Medicine

Area of Study

Immunology and Autoimmune Diseases

Populations

 

Method(s)

Cell Biology, Molecular Biology, and Genetics; Hormonal

Disease or Symptom

 

Faculty/Lab Website

http://www.nationaljewish.org/cgeh

Display on public listings?

Yes

Attachments

Created at 6/23/2010 10:59 AM by Miller, Michael
Last modified at 7/9/2013 1:53 PM by Watts, Katie