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Title

Role of microRNAs in Ewing Sarcoma oncogenesis   

Status

Open

Project Description

Ewing Sarcoma is the second most common bone and soft tissue malignancy of adolescents and young adults, with relatively poor outcome. Ewing Sarcoma is driven by a unique class of oncogenic fusions, composed of the transcriptional activation domain of the EWS protein and the DNA-binding domain of an Ets transcription factor, most commonly Fli1. We have identified a number of microRNAs that fit a profile of mediators of EWS / Ets-driven oncogenesis in Ewing Sarcoma. Using cell culture and animal tumor models, we are currently working to determine: 1) which of these microRNAs modulate Ewing Sarcoma oncogenesis; 2) what are the relevant molecular pathways involved; 3) how is the expression of these microRNAs regulated; 4) what is the therapeutic potential of these microRNAs in Ewing Sarcoma.

Mentor Name

Jedlicka, Paul

Mentor Location

Research Complex 1 North  Room P18-5119   

Mentor Contact Number

303-724-8161   

Mentor Contact Email

Paul.Jedlicka@ucdenver.edu    

Specialty

Enter Choice #1

Preceptor Name

 

Student

 

Department

Pathology

Funding Department/Program

Pathology

Area of Study

Hematology and Oncology

Populations

Adolescents

Method(s)

Cell Biology, Molecular Biology, and Genetics

Disease or Symptom

Cancer

Faculty/Lab Website

http://www.uchsc.edu/pathology/faculty/jedlicka-p.htm http://www.uchsc.edu/pathology/research/jedlicka_research.html

Display on public listings?

Yes

Attachments

Created at 7/15/2010 11:57 AM by Macfarlane, Helen
Last modified at 7/9/2013 1:59 PM by Watts, Katie