here are a variety of potential projects, most of which address issues of transplantation immunity and/or tolerance to pancreatic islet transplants in the setting of insulin-dependent diabetes. In particular, a current focus addresses the unexpected role of natural killer (NK) cells in promoting transplant tolerance induction in rodent models. Experimental approaches include the tracking the fate donor-reactive T lymphocytes derived from transgenic cells with a defined specificity for the grafted tissues/organs. Related projects with this transplantation group involve similar issues related to solid-organ heart transplantation.