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Title

Education of the Immune System by the Colonic Microbiota

Status

Open

Project Description

​Inflammatory bowel disease (IBD) affects 1.4 million Americans, and over 1/3 of them will have extra-intestinal manifestations including arthritis, uveitis, and skin disease. My lab focuses upon how colonic microbes help establish systemic tolerance and how impairment of mucosal immunity leads to systemic autoimmune diseases such as IBD. We use a genetically susceptible mouse model of IBD that is dependent upon colonization with a specific commensal organism, Bacteroides thetaiotamicron. After developing colitis, mice develop inflammatory lung disease that directly correlates with the severity of intestinal inflammation. We are interested in understanding the immune-mediated mechanisms that lead from intestinal inflammation to lung disease as well as understanding the inflammatory characteristics of the lung disease. Our goal is to use this model as a means for understanding how extra-intestinal manifestations of IBD occur.

Mentor Name

Kuhn, Kristine

Mentor Location

Barbara Davis Center M20-3102

Mentor Contact Number

303-724-8258

Mentor Contact Email

kristine.kuhn@ucdenver.edu

Specialty

Enter Choice #1

Preceptor Name

 

Student

 

Department

Medicine

Funding Department/Program

Rheumatology Grant

Area of Study

Immunology and Autoimmune Diseases

Populations

 

Method(s)

Animal Models; Cell Biology, Molecular Biology, and Genetics; Imaging; Light Microscopy

Disease or Symptom

Gastrointestinal Disease; Lung Disease

Faculty/Lab Website

 

Display on public listings?

Yes

Attachments

Created at 8/15/2013 9:23 AM by Watts, Katie
Last modified at 8/15/2013 9:23 AM by Watts, Katie