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SOM Research Projects: Determining the Originating Site of Rheumatoid Arthritis: Is It the Lung?

Title

Determining the Originating Site of Rheumatoid Arthritis: Is It the Lung?

Status

Open

Project Description

​There is a preclinical period of systemic autoimmunity in rheumatiod arthritis (RA) prior to the onset of joint symptoms. This suggests RA is initiated outside of the joints, and our overall hypothesis is that the lung is the site of origination of autoimmunity in the development of RA. With this project, we will define baseline prevalence and longitudinal evolution of RA-related autoimmunity in the lung and circulation during the preclinical period of RA through autoantibody testing of simultaneously collected serum and induced sputum samples from arthritis-free subjects at-risk for future RA. We will also  determine immunologic mechanisms of RA-related autoantibody generation in the lung through   immunohistochemical staining of lung tissue in subjects with RA, arthritis-free subjects at-risk for future RA and non-RA controls.

Mentor Name

Demoruelle, Kristen

Mentor Location

1775 Aurora Ct B-115

Mentor Contact Number

 

Mentor Contact Email

 

Specialty

Enter Choice #1

Preceptor Name

 

Student

 

Department

Medicine

Funding Department/Program

Rheumatology Grant

Area of Study

Immunology and Autoimmune Diseases

Populations

Adults

Method(s)

Clinical Imaging

Disease or Symptom

Arthritis

Faculty/Lab Website

 

Display on public listings?

Yes

Attachments

Created at 8/15/2013 9:13 AM by Watts, Katie
Last modified at 8/15/2013 9:13 AM by Watts, Katie