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Title

Epigenetic regulation of VZV gene transcription

Status

Open

Project Description

 

Varicella zoster virus (VZV) typically causes chickenpox, goes latent in multiple ganglia and can reactivate decades later to cause shingles, blindness, stroke, and spinal cord disease.  Our goal is to understand the latent phase in hopes to mitigate virus reactivation.  We have determined the VZV transcriptome during productive infection in tissue culture cells and during latency in human trigeminal ganglia.  We are currently identifying the mechanism by which transcription of VZV genes are differentially regulated.  We have shown that during latency, some VZV gene promoters contain histones with euchromatic posttranslational modifications.  We are currently developing a structural map of the latent virus genome which includes histone modifications, chromatin boundary insulators and cohesions.  

 

Mentor Name

Cohrs, Randall

Mentor Location

 

Mentor Contact Number

303-724-4325

Mentor Contact Email

randall.cohrs@ucdenver.edu

Specialty

Enter Choice #1

Preceptor Name

 

Student

 

Department

Neurology

Funding Department/Program

Neurology

Area of Study

Microbiology and Infectious Diseases

Populations

 

Method(s)

Cell Biology, Molecular Biology, and Genetics; Light Microscopy

Disease or Symptom

Infection

Faculty/Lab Website

http://www.ucdenver.edu/academics/colleges/medicalschool/departments/neurology/Faculty/Pages/Cohrs.aspx

Display on public listings?

Yes

Attachments

Created at 7/3/2012 12:40 PM by Watts, Katie
Last modified at 7/9/2013 1:55 PM by Watts, Katie