The Research Program in the Division of Urology at the UCD is focused on the mechanisms underlying pathological changes in benign urological disorders in adults and children. The research projects are centered on neural mechanisms of pelvic organ cross-sensitization, neurogenic bladder dysfunction in neurological disorders, mechanosensitivity and mechanotransduction in the human detrusor, effects of partial bladder obstruction on bladder development and function, and impact of anorectal anomalies on the genitourinary system. Additional areas of interest include stretch-activated and voltage-gated ion channels in partial bladder outlet obstruction and overactive bladder, altered contractility of the detrusor muscle in diabetes, role of pro-inflammatory neuropeptides in the development of neurogenic inflammation in the pelvis and neuropathic pain, and modulation of pelvic pain by ovarian hormones. The studies are funded by the Department of Surgery and by NIH/NIDDK grants.
Technical approaches used in the laboratory include survival rodent surgeries (mice and rats), retrograde fluorescent tracers, immunohistochemistry, cystometry, in vivo and in vitro contractility studies, patch clamp and microelectrode (in vivo) recordings, primary neuronal and smooth muscle cell cultures, ELISA, Western blotting, RT-PCRs, imaging and behavioral experiments. The Program also provides resources and support for training undergraduate and graduate students, residents and postdoctoral fellows interested in urology research. Please feel free to contact us for additional information.
With best regards,
Anna Malykhina, MSc, PhD
Principal Investigator (Adult Urology)
Duncan T. Wilcox, MBBS, MD
Principal Investigator (Pediatric Urology)