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Research

Division of Transplant Surgery


Basic science liver research

Ongoing liver research efforts are in the Division of Transplant Surgery regarding several models of ischemia-reperfusion injury and regeneration. In general, the cumulative focus is on the role of extracellular adenosine signaling following liver injury and developing therapeutic strategies to reduce post-reperfusion organ dysfunction.

At present, we have established the Human Transplant Tissue Bank which allows us to evaluate tissue changes in the setting of transplantation at both the cellular and molecular level in human specimens. This is an important tool by which to establish clinically relevant laboratory lines of investigation in vivo and in vitro.



Basic science kidney research

The best treatment for end-stage renal disease is kidney transplant. For appropriate candidates, kidney transplants decrease the rate of death in the next ten years by 50%. Unfortunately, there is a shortage of usable donor kidneys. Our ongoing research is focused on reducing the injury that occurs when a kidney is removed from a donor, stored for a short time, and then transplanted into the recipient. Limiting this injury would provide better short- and long-term results from kidneys that are currently being used, as well as allowing us to use kidneys that would otherwise be discarded.



Recent publications

Scroll down for a list of recent publications by our faculty, or view the same list as a printer-friendly PDF by clicking the link below.

Transplant Surgery Publications, 2015-2018


2018

International Liver Transplantation Society Consensus Statement on Immunosuppression in Liver Transplant Recipients. Charlton M, Levitsky J, Aqel B, OʼGrady J, Hemibach J, Rinella M, Fung J, Ghabril M, Thomason R, Burra P, Little EC, Berenguer M, Shaked A, Trotter J, Roberts J, Rodriguez-Davalos M, Rela M, Pomfret E, Heyrend C, Gallegos-Orozco J, Saliba F. Transplantation. 2018 May; 102(5):727-743. doi: 10.1097/TP.0000000000002147. PMID: 29485508

Progression of living liver donation worldwide. Nydam TL, Reddy MS, Pomfret EA, Rela M. Curr Opin Organ Transplant. 2018 Apr; 23(2):162-168. doi: 10.1097/MOT.0000000000000516. PMID: 29432257

Prevalence and Predictors of Patient-Reported Long-term Mental and Physical Health after Donation in the Adult-to-Adult Living-Donor Liver Transplantation Cohort Study. Dew MA, Butt Z, Liu Q, Simpson MA, Zee J, Ladner DP, Holtzman S, Smith AR, Pomfret EA, Merion RM, Gillespie BW, Sherker AH, Fisher RA, Olthoff KM, Burton JR Jr, Terrault NA, Fox AN, DiMartini AF. Transplantation. 2018 Jan; 102(1):105-118. doi: 10.1097/TP.0000000000001942. PMID: 28885494

Caspase inhibition during cold storage improves graft function and histology in a murine kidney transplant model. Nydam TL, Plenter R, Jain S, Lucia S, Jani A. Transplantation. 2018 May 1. doi: 10.1097/TP.0000000000002218. [Epub ahead of print]. PMID: 29757911

Utility of Viscoelastic Assays Beyond Coagulation: Can Preoperative Thrombelastography Indices Predict Tumor Histology, Nodal Disease, and Resectability in Patients Undergoing Pancreatectomy? Moore HB, Paniccia A, Lawson PJ, Torphy RJ, Nydam TL, Moore EE, McCarter MD, Schulick RD, Edil BH. J Am Coll Surg. 2018 Jul; 227(1):55-62. doi: 10.1016/j.jamcollsurg.2018.03.031. Epub 2018 Mar 30. PMID: 29605725

A Vascular Anastomosis Simulation Can Provide a Safe and Effective Environment for Resident Skills Development. Heelan Gladden AA, Conzen KD, Benge MJ, Gralla J, Kennealey PT. J Surg Educ. 2018 Apr 9. pii: S1931-7204(17)30844-9. doi: 10.1016/j.jsurg.2018.03.005. [Epub ahead of print]. PMID: 29650486

Defining kidney allograft benefit from successful pancreas transplant: separating fact from fiction. Wiseman AC, Stites E, Kennealey P. Curr Opin Organ Transplant. 2018 Aug; 23(4):448-453. doi: 10.1097/MOT.0000000000000547. PMID: 29878910


2017

Biliary reconstructive techniques and associated anatomic variants in adult living donor liver transplantations: The adult-to-adult living donor liver transplantation cohort study experience. Baker TB, Zimmerman MA, Goodrich NP, Samstein B, Pomfret EA, Pomposelli JJ, Gillespie BW, Berg CL, Emond JC, Merion RM. Liver Transpl. 2017 Dec; 23(12):1519-1530. doi: 10.1002/lt.24872. PMID: 28926171

Liver transplant in patients with portal vein thrombosis: Medical and surgical requirements. Conzen KD, Pomfret EA. Liver Transpl. 2017 Oct; 23(S1):S59-S63. doi: 10.1002/lt.24856. No abstract available. PMID: 28834305

Iron-related markers are associated with infection after liver transplantation. Chow JKL, Ganz T, Ruthazer R, Simpson MA, Pomfret EA, Gordon FD, Westerman ME, Snydman DR. Liver Transpl. 2017 Dec; 23(12):1541-1552. doi: 10.1002/lt.24817. PMID: 28703464

The International Liver Transplantation Society Living Donor Liver Transplant Recipient Guideline. Miller CM, Quintini C, Dhawan A, Durand F, Heimbach JK, Kim-Schluger HL, Kyrana E, Lee SG, Lerut J, Lo CM, Pomfret EA. Transplantation. 2017 May; 101(5):938-944. doi: 10.1097/TP.0000000000001571. PMID: 28437386

Is liver transplant education patient-centered? Bababekov YJ, Ven Fong Z, Chang DC, Simpson MA, Yeh H, Pomposelli JJ. Liver Transpl. 2017 Aug; 23(8):1070-1072. doi: 10.1002/lt.24801. Epub 2017 Jul 3. No abstract available. PMID: 28618164

Hepatic Hemodynamics and Portal Flow Modulation: The A2ALL Experience. Emond JC, Goodrich NP, Pomposelli JJ, Baker TB, Humar A, Grant DR, Abt P, Friese CE, Fisher RA, Kam I, Sherker AH, Gillespie BW, Merion RM. Transplantation. 2017 Oct; 101(10):2375-2384. doi: 10.1097/TP.0000000000001823. PMID: 28514251

Surgical Outcomes: Shifting the Focus from Measurement to Improvement. Bababekov YJ, Pomposelli JJ, Yeh H, Rudd RE, Chang DC. Ann Surg. 2017 Dec; 266(6):e103-e104. doi: 10.1097/SLA.0000000000001729. No abstract available. PMID: 27043741

Preoperative thrombelastography maximum amplitude predicts massive transfusion in liver transplantation. Lawson PJ, Moore HB, Moore EE, Stettler GR, Pshak TJ, Kam I, Silliman CC, Nydam TL. J Surg Res. 2017 Dec; 220:171-175. doi: 10.1016/j.jss.2017.05.115. Epub 2017 Jul 27. PMID: 29180179

A spontaneous pneumoperitoneum after Klebsiella-induced chronic granulomatous cholecystitis: Is the surgery warranted? Ibrahim-Zada I, Adams MA, Nydam T. J Trauma Acute Care Surg. 2017 Nov; 83(5):978-980. doi: 10.1097/TA.0000000000001643. No abstract available. PMID: 28697016

Impact of Pretransplant Bridging Locoregional Therapy for Patients with Hepatocellular Carcinoma within Milan Criteria Undergoing Liver Transplantation: Analysis of 3601 Patients from the US Multicenter HCC Transplant Consortium. Agopian VG, Harlander-Locke MP, Ruiz RM, Klintmalm GB, Senguttuvan S, Florman SS, Haydel B, Hoteit M, Levine MH, Lee DD, Taner CB, Verna EC, Halazun KJ, Abdelmessih R, Tevar AD, Humar A, Aucejo F, Chapman WC, Vachharajani N, Nguyen MH, Melcher ML, Nydam TL, Mobley C, Ghobrial RM, Amundsen B, Markmann JF, Langnas AN, Carney CA, Berumen J, Hemming AW, Sudan DL, Hong JC, Kim J, Zimmerman MA, Rana A, Kueht ML, Jones CM, Fishbein TM, Busuttil RW. Ann Surg. 2017 Sep; 266(3):525-535. doi: 10.1097/SLA.0000000000002381. PMID: 28654545


2016

Ethical issues with living donor liver transplantation. Pomfret E. Liver Transpl. 2016 Nov; 22(S1):40. doi: 10.1002/lt.24655. No abstract available. PMID: 27783892

Early Postoperative Pain and its Predictors in the Adult to Adult Living Donor Liver Transplantation Cohort Study. Mandell MS, Smith AR, Dew MA, Gordon DB, Holtzman S, Howell T, DiMartini AF, Butt Z, Simpson MA, Ladner DP, Freise CE, McCluskey SA, Fisher RA, Guarrera JV, Olthoff KM, Pomfret EA. Transplantation. 2016 Nov; 100(11):2362-2371. PMID: 27517726

Defining Benchmarks for Major Liver Surgery: A multicenter Analysis of 5202 Living Liver Donors. Rössler F, Sapisochin G, Song G, Lin YH, Simpson MA, Hasegawa K, Laurenzi A, Sánchez Cabús S, Nunez MI, Gatti A, Beltrame MC, Slankamenac K, Greig PD, Lee SG, Chen CL, Grant DR, Pomfret EA, Kokudo N, Cherqui D, Olthoff KM, Shaked A, García-Valdecasas JC, Lerut J, Troisi RI, De Santibanes M, Petrowsky H, Puhan MA, Clavien PA. Ann Surg. 2016 Sep; 264(3):492-500. doi: 10.1097/SLA.0000000000001849. PMID: 27433909

Corrigendum to "Management of the critically ill patients with cirrhosis: A multidisciplinary perspective". Nadim MK, Durand F, Kellum JA, Levitsky J, O'Leary JG, Karvellas CJ, Bajaj JS, Davenport A, Jalan R, Angeli P, Caldwell SH, Fernández J, Francoz C, Garcia-Tsao G, Ginès P, Ison MG, Kramer DJ, Mehta RL, Moreau R, Mulligan D, Olson JC, Pomfret EA, Senzolo M, Steadman RH, Subramanian RM, Vincent JL, Genyk YS. J Hepatol. 2016 May 27. pii: S0168-8278(16)30185-4. doi: 10.1016/j.jhep.2016.05.001. [Epub ahead of print] No abstract available. PMID: 27241199

Psychosocial Outcomes 3 to 10 Years after Donation in the Adult to Adult Living Donor Liver Transplantation Cohort Study. Dew MA, DiMartini AF, Ladner DP, Simpson MA, Pomfret EA, Gillespie BW, Merion RM, Zee J, Smith AR, Holtzman S, Sherker AH, Weinrieb R, Fisher RA, Emond JC, Freise CE, Burton JR Jr, Butt Z. Transplantation. 2016 Jun; 100(6):1257-69. doi: 10.1097/TP.0000000000001144. PMID: 27152918

The International Liver Transplant Society Guideline on Living Liver Donation. Miller CM, Durand F, Heimbach JK, Kim-Schluger L, Lee SG, Lerut J, Lo CM, Quintini C, Pomfret EA. Transplantation. 2016 Jun; 100(6):1238-43. doi: 10.1097/ TP.0000000000001247. PMID: 27120453

Killing Two Birds with One Stone: Antineoplastic Immunosuppression. Pomfret EA. Transplantation. 2016 Jan; 100(1):14-5. doi: 10.1097/TP.0000000000001035. No abstract available. PMID: 26647108

Management of the critically ill patient with cirrhosis: A multidisciplinary perspective. Nadim MK, Durand F, Kellum JA, Levitsky J, O'Leary JG, Karvellas CJ, Bajaj JS, Davenport A, Jalan R, Angeli P, Caldwell SH, Fernández J, Francoz C, Garcia-Tsao G, Ginès P, Ison MG, Kramer DJ, Mehta RL, Moreau R, Mulligan D, Olson JC, Pomfret EA, Senzolo M, Steadman RH, Subramanian RM, Vincent JL, Genyk YS. J Hepatol. 2016 Mar; 64(3):717-35. doi: 10.1016/j.jhep.2015.10.019. Epub 2015 Oct 28. Review. No abstract available. PMID: 26519602

Hepatic Artery Thrombosis after Liver Transplant: Not a Surgical Problem? Pomposelli JJ. Transplantation. 2016 Nov; 100(11):2251. No abstract available. PMID: 27547869

Patterns of Early Allograft Dysfunction in Adult Live Donor Liver Transplantation: The A2ALL Experience. Pomposelli JJ, Goodrich NP, Emond JC, Humar A, Baker TB, Grant DR, Fisher RA, Roberts JP, Olthoff KM, Gillespie BW, Merion RM. Transplantation. 2016 Jul; 100(7):1490-9. doi: 10.1097/TP.0000000000001240. PMID: 27326811

Fibrin Sealant Patch (TachoSil) vs Oxidized Regenerated Cellulose Patch (Surgicel Original) for the Secondary Treatment of Local Bleeding in Patients Undergoing Hepatic Resection: A Randomized Controlled Trial. Genyk Y, Kato T, Pomposelli JJ, Wright JK Jr, Sher LS, Tetens V, Chapman WC. J Am Coll Surg. 2016 Mar; 222(3):261-8. doi: 10.1016/ j.jamcollsurg 2015.12.007. Epub 2015 Dec 18. PMID: 26776356

Predicting renal recovery after liver transplant with severe pretransplant subacute kidney injury: The impact of warm ischemia time. Laskey HL, Schomaker N, Hung KW, Asrani SK, Jennings L, Nydam TL, Gralla J, Wiseman A, Rosen HR, Biggins SW. Liver Transpl. 2016 Aug; 22(8):1085-91. doi: 10.1002/lt.24488. Epub 2016 Jul 12. PMID: 27302834

Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma vs lymph. D'alessandro A, Nemkov T, Moore HB, Moore EE, Wither M, Nydam T, Slaughter A, Silliman CC, Banerjee A, Hansen KC. Blood Transfus. 2016 May; 14(2):185-94. doi: 10.2450/2016.0208-15. Epub 2016 Apr 22. PMID: 27177401

Donor preoperative oxygen delivery and post-extubation hypoxia impact donation after circulatory death hypoxic cholangiopathy. Chirichella TJ, Dunham CM, Zimmerman MA, Phelan EM, Mandell MS, Conzen KD, Kelley SE, Nydam TL, Bak TE, Kam I, Wachs ME. World J Gastroenterol. 2016 Mar 28; 22(12):3392-403. doi: 10.3748/wjg.v22.i12.3392. PMID: 27022221

Transfemoral Transcatheter Aortic Valve Replacement for Mixed Aortic Valve Disease in Child's Class C Liver Disease Prior to Orthotopic Liver Transplantation: A Case Report. Wilkey BJ, Hanson R, Reece TB, Forman L, Burton JR Jr, Messenger JC, Kim MS, Cleveland JC Jr, Fiegel MJ, Nydam TL, Mandell MS. Semin Cardiothorac Vasc Anesth. 2016 Jun; 20(2):158-62. doi: 10.1177/1089253215619235. Epub 2015 Nov 29. PMID: 26620139

Pathologic sequelae of allosensitization in liver transplantation. Zimmerman MA, Schiller J, Kim J, Martin A, Selim M, Nydam TL, Cronin D 2nd, Hong JC. J Surg Res. 2016 Jan; 200(1):195-9. doi: 10.1016/j.jss.2015.06.047. Epub 2015 Jun 26. Review. PMID: 26253457

Current status of pancreas transplantation. Stites E, Kennealey P, Wiseman AC. Curr Opin Nephrol Hypertens. 2016 Nov; 25(6):563-569. Review. PMID: 27653421


2015

Safety using small grafts: Western perspective. Pomfret EA, Pomposelli JJ. Liver Transpl. 2015 Nov; 21 Suppl 1:S15-6. doi: 10.1002/lt.24314. Review. No abstract available. PMID: 26335959

Defining long-term outcomes with living donor liver transplantation in North America. Olthoff KM, Smith AR, Abecassis M, Baker T, Emond JC, Berg CL, Beil CA, Burton JR Jr, Fisher RA, Freise CE, Gillespie BW, Grant DR, Humar A, Kam I, Merion RM, Pomfret EA, Samstein B, Shaked A. Ann Surg. 2015 Sep;262(3):465-75; discussion 473-5. doi: 10.1097/ SLA.0000000000001383. PMID: 26258315

Impact of geography on organ allocation: Beyond the distance to the transplantation center. Ghaoui R, Garb J, Gordon F, Pomfret E. World J Hepatol. 2015 Jul 8; 7(13):1782-7. doi: 10.4254/wjh.v7.i13.1782. PMID: 26167251

President's Address: International Liver Transplantation Society. Chapman JR, Pomfret EA. Transplantation. 2015 Jul; 99(7):1301. doi: 10.1097/TP.0000000000000822. No abstract available. PMID: 26147130

Surgical resection and liver transplantation for hepatocellular carcinoma. Akoad ME, Pomfret EA. Clin Liver Dis. 2015 May; 19(2):381-99. doi: 10.1016/j.cld.2015.01.007. Epub 2015 Mar 2. Review. PMID: 25921669

Changes in liver and spleen volumes after living liver donation: a report from the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL). Emond JC, Fisher RA, Everson G, Samstein B, Pomposelli JJ, Zhao B, Forney S, Olthoff KM, Baker TB, Gillespie BW, Merion RM. Liver Transpl. 2015 Feb; 21(2):151-61. doi: 10.1002/lt.24062. PMID: 25488878

Murine Kidney Transplant Technique. Plenter R, Jain S, Ruller CM, Nydam TL, Jani AH. J Vis Exp. 2015 Oct 20; (105):e52848. doi: 10.3791/52848. PMID: 26555373

Hepatocellular carcinoma in patients listed for liver transplantation: Current and future allocation policy and management strategies for the individual patient. Wedd JP, Nordstrom E, Nydam T, Durham J, Zimmerman M, Johnson T, Thomas Purcell W, Biggins SW. Liver Transpl. 2015 Dec; 21(12):1543-52. doi: 10.1002/lt.24356. Review. PMID: 26457885

Revised Arterial Anastomosis for Improving Murine Kidney Transplant Outcomes. Plenter RJ, Jain S, Nydam TL, Jani AH. J Invest Surg. 2015; 28(4):208-14. doi: 10.3109/08941939.2014.1002641. Epub 2015 Jun 18. PMID: 26087146

The corrected donor age for hepatitis C virus-infected liver transplant recipients. Dirchwolf M, Dodge JL, Gralla J, Bambha KM, Nydam T, Hung KW, Rosen HR, Feng S, Terrault NA, Biggins SW. Liver Transpl. 2015 Aug; 21(8):1022-30. doi: 10.1002/lt.24194. PMID: 26074140

Inhibition of autophagy increases apoptosis during re-warming after cold storage in renal tubular epithelial cells. Jain S, Keys D, Nydam T, Plenter RJ, Edelstein CL, Jani A. Transpl Int. 2015 Feb;28(2):214-23. doi: 10.1111/tri.12465. Epub 2014 Oct 29. PMID: 25270002

Intrahepatic antiviral quantification in a patient undergoing orthotopic cadaveric liver transplantation. Moorehead KJ, Burton JR Jr, Everson GT, Zheng JH, Kerr BJ, Bushman LR, Wang M, Ju C, Nydam T, Kiser JJ. J Antimicrob Chemother. 2015 Jan; 70(1):315-7. doi: 10.1093/jac/dku334. Epub 2014 Sep 11. No abstract available. PMID: 25213274

BH3-only proteins contribute to steatotic liver ischemia-reperfusion injury. DuBray BJ Jr, Conzen KD, Upadhya GA, Gunter KL, Jia J, Knolhoff BL, Mohanakumar T, Chapman WC, Anderson CD. J Surg Res. 2015 Apr; 194(2):653-8. doi: 10.1016/j.jss.2014.10.024. Epub 2014 Oct 22. PMID: 25483735

Morbid obesity in liver transplant recipients adversely affects long-term graft and patient survival in a single-institution analysis. Conzen KD, Vachharajani N, Collins KM, Anderson CD, Lin Y, Wellen JR, Shenoy S, Lowell JA, Doyle MB, Chapman WC. HPB (Oxford). 2015 Mar; 17(3):251-7. doi: 10.1111/hpb.12340. Epub 2014 Oct 17. PMID: 25322849