Our vision is to foster an organization where sustained interactions between clinical patient database/samples, bench experiments combined with discoveries on inflammatory signaling maximize the opportunity to develop mechanistic insights into the body’s response to trauma, and improve clinical practice.
Our specific objectives during this cycle are to:
1. Investigate the inflammatory biology of mesenteric lymph after shock and resuscitation.
2. Investigate problems of blood products and current transfusion therapy
3. Investigate anti-inflammatorily effects of hyperosmolarity and apply to patient ventilator therapy.
4. Maintain and mine the patient MOF database.
5. Maintain and develop molecular tools to study patient samples
6. Maintain an administrative system that promotes interdisciplinary research in full compliance with regulations and prudent financial practice.
Our GOAL is to maintain a rich environment whereby the following OBJECTIVES are accomplished:
i. researchers (guests, fellows, experts, Project leaders) can discuss each other’s goals and results intensively (and repeatedly);
ii. equipment, reagents and experiments are shared to maximize resources;
iii. teams exchange their ‘core expertise’ with others, on a daily/weekly basis.
younger researchers and faculty are allowed to take the lead on limited aspects of Projects, while collaborating closely with experienced investigators, stimulating excitement and offering the best opportunity for serendipitous discovery. At the same time, it protects senior researchers from perpetuating any biases in their paradigms, while remaining in position to take full advantages of the findings and accomplish timely publication.
Our STRATEGIES: Our weekly Friday meeting remains intensive, open and with lively discussion. This meeting starts at 6:00am and traditionally runs 2-3 hrs. Residents, fellows, and PIs present for about 30 min to 1 hour each. During these sessions, the emphasis is to improve the presentation of the study, to solve methodological obstacles as a group, and to challenge data interpretation with alternative explanations and constructive suggestions. Techs, PRAs, students and attending guests are actively encouraged to take positions in the frequent debates. Repeated presentation (week after week) aids in familiarity among discussants, clarity of presentation, and the fostering of fresh perspectives. The spin-off from this process is lateral translation between projects. Scientific philosophy, epistemology and cultural ethics are inculcated during brief (5 minute) synopses of classical readings (usually from the Harvard Classics) with which every presenter must close. Subgroups hold meetings with PRAs and fellows to evaluate their weekly progress (Moore group with Silliman/Banerjee) and prepare for the larger Friday conference. These subgroup efforts are housed at separate institutions (Moore at Denver Health and Hospital Authority, Banerjee at UCDC and Silliman at Belle Bonfils Blood Center) and so profit by this extra meeting. All other project leaders meet regularly with their support staff and special collaborators.
With these strategies, objectives ii and iii are facilitated by the umbrella provided by the Center grant. Objective ii is achieved through a common budget, with monthly expenses broken by Project, and expensive orders are charged separately as appropriate. Objective iv, promoting younger researchers and faculty to take the lead is accomplished as part of the ground rules of the meetings on Friday (and others).