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MR Physics

Mark Brown, PhD

Yiping Du, PhD

Methodological Development of fMRI Techniques

Dr. Du has developed a volume-selective z-shim technique to reduce the susceptibility artifacts in fMRI studies. In this technique, z-shim compensation is applied only to a few selected slices in a whole brain fMRI study. As a result, the time penalty for multiple acquisitions at the z-shim slices is greatly reduced. Using this technique, BOLD activations can be effectively detected at the orbito-frontal cortex in whole brain fMRI with a TR of 2 seconds (see Fig. 1). This technique has currently being used in the fMRI studies of drug addiction, alcoholism, and behavioral disorders.

Quantitative Mapping of Myelin Water Fraction (MWF) in the brain
Artifact reduction in Echo-Planar Spectroscopic Images (EPSI)
Improving the accuracy of functional maps
Novel ROC Methods for Assessing Processing Techniques
Exploratory Analysis Using ICA