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Department of Psychiatry

Department of Psychology

Jason Tregellas, PhD
       Jason R. Tregellas, PhD

Bldg. 500, Level 2, Rm. E4311
Phone:  303-724-6232
Email:  Dr. Tregellas
 

Recent publications

 

 

 

Jason R. Tregellas, PhD

Associate Professor


ACADEMIC APPOINTMENTS, PROFESSIONAL POSITIONS, AND HONORS

Positions and Employment:

Postdoctoral Fellow, Institute for Cognitive Neuroscience, Univ. College London, 2004

Instructor/Fellow, Developmental Psychobiology Research Group, Department of Psychiatry, University of Colorado Health Sciences Center, 2004-2005

Associate Investigator, Denver Veterans Affairs Medical Center Research Service, 2006-2008

Assistant Professor, Department of Psychiatry, University of Colorado Denver, 2005-2011

Associate Professor, Department of Psychiatry, University of Colorado Denver, 2011-present

Member, Neuroscience Program, University of Colorado Denver, 2006-present

Associate Director, University of Colorado Denver, Brain Imaging Center, 2007-2012

Research Biologist, Denver Veterans Affairs Medical Center Research Service, 2008-present

Director, University of Colorado Denver, Brain Imaging Center, 2013-present

 

Honors:

Univ. of Colorado Health Sciences Center Graduate School Ph.D. Training Fellowship, 1999

National Research Service Award, National Institute of Mental Health. “FMRI of Cholinergic Dysfunction in Schizophrenia,” Grant Number # 1 F31 MH66533-01, 2002-2003

International Congress on Schizophrenia Research Young Investigator Award, 2005

National Alliance for Research on Schizophrenia and Depression (NARSAD), Young Investigator Award.  “fMRI of Auditory Gating in Schizophrenia.” 2005-2007 

Veterans Affairs Medical Center Research Service Associate Investigator Award, 2006-2009

Dana Foundation Program in Brain and Immuno-imaging Grant, Effect of Genotype on Brain Function and Structure in Schizophrenia, 2006-2010

American College of Neuropsychopharmacology Young Investigator Award, 2007

 

Teaching Activities:

“Biological Basis of Psychiatric and Neurological Disorders,” Course Director, University of Colorado Anschutz Medical Campus, 2009 - present

“Introduction to Neuroimaging,” University of Colorado at Denver and Health Sciences Center, 6/2006, 6/2007, 6/2008, 6/2009

“Introduction to Neuroimaging and Its use in Psychology,” Invited lecture for Clinical Psychology graduate program at the University of Denver, 5/2009

“Neurobiology of Psychiatric Disorders” Course co-director, University of Colorado at Denver and Health Sciences Center, 2008

“Functional Magnetic Resonance Imaging,” Invited lecture for “Physics of Life” course for the University of Denver, 9/2008

“Neuropsychology Seminar“ Intern lecture series, University of Colorado at Denver and Health Sciences Center, 1/2007

“Neuroimaging Research Applications”, Resident seminar,” University of Colorado at Denver and Health Sciences Center, 11/2006

“fMRI Data Analysis Workshop,” University of Colorado at Denver and Health Sciences Center, 8/2006

 

Clinical Activities:

Not applicable

 

SCHOLARSHIPS AND PUBLICATIONS

Selected Peer-Reviewed Publications:

Tregellas, J.R., Olincy, A., Johnson, L., Tanabe, J., Shatti, S., Martin, L.F., Singel, D., Du, Y.P., Soti, F., Kem, W.R., Freedman, R.  Functional Magnetic Resonance Imaging of Effects of a Nicotinic Agonist in Schizophrenia. Neuropsychopharmacology (In Press).

Tregellas, J.R., Ellis, J., Shatti, S., Du, Y.P., Rojas D.C. Increased Hippocampal, Thalamic, and Prefrontal Hemodynamic Response to an Urban Noise Stimulus in Schizophrenia.  Am J Psychiatry 2009; Mar;166(3):354-60.

Tregellas, J.R.  Connecting Brain Structure and Function in Schizophrenia.  Am J Psychiatry. 2009; Feb;166(2):134-6

Cornier, M.A., Salzberg, A.K., Endly, D.C., Bessesen, D.H., Rojas, D.C., Tregellas, J.R. The Effects of Overfeeding on the Neuronal Response to Visual Food Cues in Thin and Reduced-Obese Individuals. PLoS ONE (In Press).

Wilson, L.B., Tregellas, J.R., Hagerman, R.J., Rogers, S.J., Rojas, D.C.  A voxel-based morphometry comparison of regional gray matter between fragile X syndrome and autism.  Psychiatry Research: Neuroimaging (In Press).

Tanabe, J., Tregellas, J.R., Dalwani, M., Thompson, L., Owens, E. Crowley, T., Banich, M.  Medial orbitofrontal cortex gray matter is reduced in abstinent substance dependent individuals. Biol Psych. 2008; 65(2):160-164.

Tregellas, J.R., Shatti, S., Tanabe, J.L., Martin, L.F., Gibson, L., Wylie, K., Rojas, D.C.   Gray Matter Volume Differences and the Effects of Smoking on Gray Matter in Schizophrenia.  Schizophr Res. 2007; 97:242-249.

Tregellas, J.R., Davalos, D.B., Rojas, D.C., Waldo, M.C., Gibson, L., Wylie, K., Du, Y.P. & Freedman, R.  Increased hemodynamic response in the hippocampus, thalamus and prefrontal cortex during abnormal sensory gating in schizophrenia.  Schizophr Res. 2007; 92:262-272.

Cornier, M.A., VonKaenel, S.S., Bessesen, D.H., Tregellas, J.R.  The effects of overfeeding on the neuronal response to visual food cues. Am J Clin.Nutr. 2007; 86:965-971.

Du, Y.P., Dalwani, M., Wylie, K., Claus, E, Tregellas, J.R.  Reducing Susceptibility Artifacts in fMRI Using Volume-Selective Z-Shim Compensation.  Magnetic Resonance in Medicine 2007; 57:396-404.

Rojas, D.C., Peterson, E., Winterrowd, E., Reite, M.L., Rogers, S.J., Tregellas, J.R.  Regional Gray Matter Volumetric Changes in Autism Associated with Social and Repetitive Behavior Symptoms.  BMC Psychiatry. 2006; Dec 13;6:56.

Martin, L.F., Leonard, S., Hall, M., Tregellas, J.R., Freedman, R., Olincy, A.  Sensory Gating and Alpha-7 Nicotinic Receptor Gene Allelic Variants in Schizoaffective Disorder, Bipolar Type.  Am J Med Genet B Neuropsychiatr Genet 2006.

Tregellas, J.R., Davalos, D.B., Rojas, D.C. Effect of Task Difficulty on the Functional Anatomy of Temporal Processing.  Neuroimage 2006; 32:307-315.

Peterson, E., Schmidt, G.L., Tregellas, J.R., Winterrowd, E., Kopelioff, L., Hepburn, S., Reite, M., Rojas, D.C.  A Voxel-Based Morphometry Study of Gray Matter in Parents of Children with Autism. Neuroreport 2006; 17:1289-1292.

Tanabe, J. L., Tregellas, J. R., Martin, L.F., Freedman, R.  Effects of Nicotine on Hippocampal and Cingulate Activity During Smooth Pursuit Eye Movement in Schizophrenia.  Biological Psychiatry 2006. 59(8):754-761.

Haynes, J., Tregellas, J., Rees, G.  Attentional Integration Between Anatomically Distinct Stimulus Representations in Early Visual Cortex.  Proc Natl Acad Sci USA. 2005 102(41):14925-14930.

Freedman, R., Ross, R., Leonard, S., Myles-Worsley, M., Adams, C.E., Waldo, M., Tregellas, J., Martin, L., Olincy, A., Tanabe, J., Kisley, M.A., Hunter, S., Stevens, K.E.  Early Biomarkers of Psychosis.  Dialogues in Clinical Neuroscience. 2005 7(1):17-29.

Tregellas, J. R., Tanabe, J. L., Martin, L. F. and Freedman, R. fMRI of Response to Nicotine During a Smooth Pursuit Eye Movement Task in Schizophrenia. Am J Psychiatry. 2005 Feb;162(2):391-3.

Harris JG, Kongs S, Allensworth D, Martin L, Tregellas J, Sullivan B, Zerbe G, Freedman R. Effects of Nicotine on Cognitive Deficits in Schizophrenia. Neuropsychopharmacology. 2004 Jul;29(7):1378-85.

Tregellas, J. R., Tanabe, J. L., Miller, D. S., Ross, R.G., Olincy, A. and Freedman, R. Neurobiology of Smooth Pursuit Eye Movement Deficits in Schizophrenia: An fMRI Study. Am J Psychiatry. 2004;161(2):315-21.

Tregellas, J. R., Tanabe, J L., Miller, D. S., and Freedman, R. Monitoring Eye Movements During fMRI Tasks with Echo Planar Images.  Hum Brain Mapp. 2002; 17(4):237-243.

Tanabe, J. L., Tregellas, J. R., Miller, D. S., Ross, R.G. and Freedman, R.  Brain activation during smooth pursuit eye movements. NeuroImage. 2002; 17, 1315–1324.

Tanabe,J., Miller,D., Tregellas,J., Freedman,R., and Meyer,F.G. Comparison of Detrending Methods for Optimal fMRI Preprocessing. Neuroimage. 2002; 15, 902-907.

 

Grants and Contracts:

Veterans Affairs Medical Center Research Service Merit Review Award, “fMRI of Cholinergic Mechanisms in Schizophrenia” (Tregellas, PI), 10/1/2008- 9/30/2011

Funding is provided to study the neuronal substrates of sensory gating deficits in schizophrenia and the mechanism by which clozapine and nicotine improve sensory gating.

 

Dana Foundation Program in Brain and Immuno-imaging Grant, “Effect of Genotype on Brain Function and Structure in Schizophrenia.” (Tregellas, PI), 7/1/2006 – 6/30/2010

Funding is provided to evaluate the effect of polymorphisms in the nicotinic receptor gene on brain function (using fMRI) and structure (using VBM).

 

NIH R01, 2007-2012 #DK072174 (Cornier, PI), 7/01/2007-6/30/2012

Funding is provided to study the effects of food intake on behavior and brain hemodynamic response in obese and obese-resistant individuals. 

 

NIH P50 MH086383-01, (Freedman, PI), 8/1/2009- 7/31/2014   

The aims of this Translational Conte Center are to characterize the role of the alpha7 nicotinic acetylcholine receptor in the brain and its dysfunction and to use this biology to continue development of a new therapeutic strategy to improve the treatment of cognitive dysfunction and negative symptoms in persons who have schizophrenia

 

NIH R01 MH081920 (Rojas,PI) 12/01/08-11/30/2013, Sensorimotor abnormalities in childhood onset psychotic disorders

The goal of this research is to refine the neurobiology of motor deficits in psychotic disorders across category and develop biomarkers for future family-based genetic risk.