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Ann Olincy, MD, MPH

Associate Professor


Contact Info:

Email: Dr. Olincy

Clinical/Research Interests:

Dr. Olincy's interests center on schizophrenia, particularly the associated cognitive deficits, the neurological effects of nicotine in schizophrenia, and the genetics of the disorder.​

Brandeis University  BA  1983

UCLA School of Public Health  MPH  1986

Mayo Medical School  MD  1990      

Selected Peer-Reviewed Publications:

Olincy A, Harris JG, Johnson,LL, Pender V, Kongs S, Allensworth D, Ellis J Zerbe, GO, Leonard S, Stevens KE Stevens JO, Martin L, Adler LE, Soti F, Kem WR, Freedman R.  Proof-of-concept Trial of an α7 Nicotinic Agonist in Schizophrenia. Archives of General Psychiatry,63:630-38, 2006.

Calkins ME, Dobie DJ, Cadenhead KS, Olincy A, Freedman R, Green M, Greenwood TA, Gur RE, Gur RE, Light GA, Mintz J, Nuechterlein KH, Radant AD, Schork NJ, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Braff DL.  The Consortium on the Genetics of Endophenotypes in Schizophrenia (COGS): “Model” Recruitment, Assessment, and Endophenotyping Methods for a Multi-Site Colloboration. Schizophrenia Bulletin. 33:33-48, 2007.

Greenwood TA, Braff DL, Cadenhead KS, Calkins ME, Dobie DJ, Freedman R, Green M, Gur RE, Gur RE, Light GA, Mintz J, Nuechterlein KH, Olincy A, Radant AD, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Schork NJ.  The Consortium on the Genetics of Endophenotypes in Schizophrenia (COGS): Preliminary Heritability Analyses of Endophenotypic Measures for Schizophrenia. Archives of General Psychiatry, 64(11): 1242-1250, 2007.

Martin LF Hall MH, Ross RG, Zerbe G, Freedman R, Olincy A.  Physiology of schizophrenia, bipolar disorder, and schizoaffective disorder.  American Journal of Psychiatry.  164(12):1900-6, 2007.

Martin LF, Leonard S, Hall M-H, Tregellas JR, Freedman R, Olincy A.  Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type.  American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics. 144(5):611-4, 2007.

Radant AD, Dobie DJ, Calkins ME, Olincy A, Braff DL, Cadenhead KS, Freedman RF, Green MF, Greenwood TA, Gur RE, Light GA, Meichle SP, Mintz J,. Nuechterlein KH, Schork NJ, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang MT, Turesky BI, Tsuang DW Successful multi-site measurement of antisaccade performance deficits in schizophrenia Schizophrenia Research. 89(1-3):320-9, 2007.

Swerdlow NR, Sprock J, Light GA, Cadenhead K, Calkins ME, Dobie DJ, Freedman R, Green M, Greenwood TA, Gur RE, Gur RE, Mintz J, Nuechterlein KH, Olincy A, Radant AD, Schork NJ, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Braff DL.  Multi-site Studies of Acoustic Startle and Prepulse Inhibition in Humans: Initial Experience and Methodological Considerations based on Studies by the Consortium on the Genetics of Schizophrenia .  Schizophrenia Research.  92(1-3): 237-51, 2007.

Horan, W.P., Braff, D.L., Nuechterlein, K.H., Sugar, C.A., Cadenhead, K.S., Calkins, M.D., Dobie, D.J., Freedman, R., Greenwood, T.A., Gur, R.E., Gur, R., Light, G.A., Mintz, J., Olincy A, Radant, A.D., Schork, N.J., Seidman, L.J., Siever, L.J., Silverman, J.M., Stone, W.S., Swerdlow, N.R., Tsuang, D.W., Tsuang, M.T., Turetsky, B.I., Green, M.F. (in press).  Verbal Working Memory Impairments in Individuals with Schizophrenia and Their First-Degree Relatives: Findings From the Consortium on the Genetics of Schizophrenia. Schizophrenia Research. 103(1-3):218-28, 2008

Sanders, Alan R. Duan, Jubao. Levinson, Douglas F. Shi, Jianxin. He, Deli. Hou, Cuiping. Burrell, Gregory J. Rice, John P. Nertney, Deborah A. Olincy, Ann. Rozic, Pablo. Vinogradov, Sophia. Buccola, Nancy G. Mowry, Bryan J. Freedman, Robert. Amin, Farooq. Black, Donald W. Silverman, Jeremy M. Byerley, William F. Crowe, Raymond R. Cloninger, C Robert. Martinez, Maria. Gejman, Pablo V.  No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics American Journal of Psychiatry. 165(4):497-506, 2008

Freedman R,  Olincy A, Buchanan RW, Harris JG,  Gold JM, Johnson L,  Allensworth D, Guzman A, Clement B, Ball P, Kutnick J, Pender V, Martin L, Stevens KE, Wagner B, Zerbe G, Soti, Kem WF. Initial Phase 2 Trial of a Nicotinic Agonist in Schizophrenia, American Journal of Psychiatry, 165(8):1040-7, 2008

Turetsky BI. Greenwood TA. Olincy A. Radant AD. Braff DL. Cadenhead KS. Dobie DJ. Freedman R. Green MF. Gur RE. Gur RC. Light GA. Mintz J. Nuechterlein KH. Schork NJ. Seidman LJ. Siever LJ. Silverman JM. Stone WS. Swerdlow NR. Tsuang DW. Tsuang MT. Calkins ME. Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia Probands.  Biological Psychiatry. 64(12):1051-9, 2008.

Shi J. Levinson DF. Duan J. Sanders AR. Zheng Y. Pe'er I. Dudbridge F. Holmans PA. Whittemore AS. Mowry BJ. Olincy A. Amin F. Cloninger CR. Silverman JM. Buccola NG. Byerley WF. Black DW. Crowe RR. Oksenberg JR. Mirel DB. Kendler KS. Freedman R. Gejman PV. Nature. 460(7256):753-7, 2009.

Olincy A, Braff DL,. Adler LE, Cadenhead KS, Calkins ME,. Dobie DJ, Green MF5, Greenwood TA,. Gur RE, Gur RC, GA, Mintz  J, NuechterleinKH, Radant AD,  Schork NJ, Seidman LJ, Siever LJ, Silverman JM , Stone WS,. Swerdlow NR,. Tsuang DW,. Tsuang MT,. Turetsky BI, Wagner BD, Freedman R.  Inhibition of the P50 Cerebral Evoked Response to Repeated Auditory Stimuli: Results from the Consortium on Genetics of Schizophrenia.  Schizophrenia Research.

Tregellas, J.R.Olincy, A., Johnson, L., Tanabe, J., Shatti, S., Martin, L.F., Singel, D., Du, Y.P., Soti, F., Kem, W.R., Freedman, R.  Functional Magnetic Resonance Imaging of Effects of a Nicotinic Agonist in Schizophrenia. Neuropsychopharmacology (In Press).

 

NIMH Co-Investigator, 5/06-4/11, 5 R01 MH61412-05 (P.I. Freedman, R), $1,7,83,653

"Nicotinic Agonists in Schizophrenia".  This grant is to determine the optimal dosing strategy for sustained use of DMXB-A in smokers and non-smokers with schizophrenia to treat cognitive deficits.

NIMH Co-Investigator, 8/01/2009- 7/31/2014, 1 P50 MH086383-01 (P.I. Freedman, R),   $2,102,458 

Basic to Clinical Molecular Neurobiology of Nicotinic Receptors in Schizophrenia” The aims of this Translational Conte Center are to characterize the role of the alpha7 nicotinic acetylcholine receptor in the brain.

Veterans Affairs Medical Research Service, VA Merit Review, Co-Investigator, 10/1/09 - 9/30/13 (P.I. Freedman. R).

“Nicotinic Receptors and Schizophrenia” This proposal will examine the effects of 3-2,4 dimethoxybenzylidene anabaseine (DMXB-A) and Neurocognitive improvement in Veterans with schizophrenia