ACADEMIC APPOINTMENTS, PROFESSIONAL POSITIONS, AND HONORS
Positions and Employment:
Course Instructor, Research Methods in Somatic Cell & Molecular Genetics, a Laboratory course offered by the Eleanor Roosevelt Institute, 1984-1986
Postdoctoral Fellow, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 1987-1992
Scientist, Eleanor Roosevelt Institute, Denver, CO, 1992-2003
Instructor, Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Denver, CO, 1992-2003
Graduate Faculty and Graduate Advisor, Department of Biology, University of Colorado at Denver, Denver, CO, 1994-Present
Faculty Member, Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, CO, 2000-2003
Assistant Professor, Eleanor Roosevelt Institute, University of Denver, Denver, CO, 2003-2005
Associate Research Professor, Eleanor Roosevelt Institute, University of Denver, Denver, CO, 2005-2007
Assistant Professor, University of Colorado at Denver and Health Sciences Center, Department of Psychiatry, Anschutz Medical Campus, Aurora, CO, 2007-Present
Other Experience and Professional Memberships:
American Board of Genetic Counseling
• Certified Genetic Counselor (C.G.C.)
American Heart Association of Colorado/Wyoming
• 1994-1997, Peer Review Committee
• 1996, 1997, Chairman, Peer Review Committee
• 1996-2001, Research Committee
National Institutes of Health
• 1997, Member, Ad hoc General Medicine B Study Section
Teaching Activities:
Invited lecturer in GENC6111, Topics in Medical Genetics II.
SCHOLARSHIPS AND PUBLICATIONS
Selected Peer-Review Publications:
Patterson D, Graw S and Jones C. Demonstration by somatic cell genetics, of coordinate regulation of genes for two enzymes of purine synthesis assigned to human chromosome 21. Proc. Natl. Acad. Sci USA 78:405-409 (1981).
Patterson D, Jones C, Scoggins C, Miller YE and Graw S. Somatic cell genetic approaches to Down syndrome. Ann. NY Acad. Sci. 396:69-81 (1982).
Hards RG, Benkovic SJ, Van Keuren ML, Graw SL, Drabkin HA and Patterson D. Assignment of a third purine biosynthetic gene (glycinamide ribonucleotide transformylase) to human chromosome 21. Am. J. Hum. Gen. 39:179-185 (1986).
Graw S, Davidson J, Gusella J, Watkins P, Tanzi R, Neve R and Patterson D. Irradiation-reduced human chromosome 21 hybrids. Somat. Cell & Molec. Genet. 14:233-242 (1988).
Emanuel JR, Graw S, Houseman D and Levenson R. Identification of a region within the Na,K-ATPase a subunit that contributes to differential Ouabain sensitivity. Molec. Cell Biol. 9:3744-3749 (1989).
Tam S-Y, Geissler EN, Graw SL and Housman DE. Functional expression of the genomic DNA sequences encoding mouse Na,K-ATPase a-1 gene by cotransfection of overlapping genomic DNA segments. Mol. Cell. Biol. 10:6619-6623 (1990).
Buckler AJ, Chang DD, Graw SL, Brook JD, Haber DA, Sharp PA and Housman DE. Exon amplification: A strategy to isolate mammalian genes based on RNA splicing. Proc. Natl. Acad. Sci. USA 88:4005 (1991).
Graw SL, Schalling M, Housman D, Callen DF, Klinger K, Landes G and Lerner T. Isolation and characterization of a candidate gene for autosomal dominant polycystic kidney disease. Contributions to Nephrology, eds. Berlyne GM and Giovannetti S. Vol. 97. Polycystic Kidney Disease. Eds. Breuning MH, Devoto M and Romeo G. Karger, New York, pp. 110-117 (1992).
Fountain WJ, Karayiorgou M, Taruscio D, Graw SL, Buckler AJ, Ward DC, Dracopoli NC and Housman DE. Genetic and physical map of the 'interferon region' on chromosome 9p. Genomics 14:105-112 (1992).
Jackson CL, Britt DE, Graw SL, Potts A, Santoro K, Buckler AJ, Housman DE and Mark HFL. Construction and characterization of radiation hybrids for chromosome 9, and their use in mapping cosmid probes on the chromosome. Somat. Cell & Molec. Genet. 18:285-301 (1992).
Graw SL, Buckler AJ, Britt DE, Jackson CL, Taruscio D, Baldini A, Ward DC and Housman DE. Generation and characterization of a human chromosome 9 cosmid library. Somat. Cell & Molec. Genet. 18:269-284 (1992).
Church DM, Banks LT, Rogers AC, Graw SL. Identification of human chromosome 9 specific genes using exon amplification. Hum. Mol. Genet. 2:1915-1920 (1993).
Graw SL and Kwiatkowski DJ. Three dinucleotide repeat polymorphisms on chromosome 9 (D9S200, D9S201, D9S199). Hum. Mol. Genet. 2:614 (1993).
Hunter KW, Ontiveros SD, Watson ML, Stanton Jr. VP, Gutierrez P, Bhat D, Rochelle J, Graw S, Ton C, Schalling M, Aburatani H, Brown SDM, Seldin MF, Housman DE. Rapid and efficient construction of yeast artificial chromosome contigs in the mouse genome with interspersed repetitive sequence PCR (IRS-PCR): Generation of a 5-cM, >5 megabase contig on mouse Chromosome 1. Mammalian Genome 5:597-607 (1994).
Soeda E, Hou DX, Osoegawa K, Atsuchi Y, Yamagata T, Shimokawa T, Kishida H, Okano S, Chumakov I, Cohen D, Raff M, Gardiner K, Graw SL, Patterson D, DeYong P, Ashworth LK, Slezak T, Carrano AV. Cosmid assembly and anchoring to human chromosome 21. Genomics 25:73-84 (1995).
Xu H, Wei H, Tassone F, Graw S, Gardiner K and Weissman SM. A search for genes from the dark band regions of human chromosome 21. Genomics 27:1-8 (1995).
Nahmias J, Hornigold N, Fitzgibbon J, Woodward K, Pilz A, Griffin D, Henske EP, Nakamura Y, Graw S, Florian P, Benham F, Povey S and Wolfe J. Cosmid contigs spanning 9q34 including the candidate region for TSC1. Eur. J. Hum. Genet. 3:65-77 (1995).
Graw SL, Gardiner K, Hall-Johnson K, Hart I, Joetham A, Walton K, Donaldson D and Patterson D. Molecular analysis and breakpoint definition of a set of human chromosome 21 somatic cell hybrids. Somat. Cell & Molec. Genet. 21:415-428 (1995).
Gardiner K, Graw S, Ichikawa H, Ohki M, Chumakov I and Patterson D. YAC analysis and minimal tiling path construction for chromosome 21q. Somat. Cell & Molec. Genet.21:399-414 (1995).
Bosch A, Guimera J, Graw S, Gardiner K, Chumakov I, Patterson D and Estivill X. Integration of 30 CA-repeat markers into the cytogenetics, genetic and YAC maps of human chromosome 21. European J Hum Genet 4:135-142 (1996).
Graw SL, Sample T, Bleskan J, Sujansky E, Patterson D. Cloning, sequencing, and analysis of Inv8 chromosome breakpoints associated with Recombinant 8 syndrome. Am J Hum Genet 66:1138-1144 (2000).
Giglio S, Graw SL, Gimelli G, Pirola B, Varone P, Voullaire L, Lerzo F, Dellavecchia C, Bonaglia MC, Digilio MC, Giannotti A, Marino B, Carrozzo R, Korenberg JR, Danesino C, Sujansky E, Dallapiccola B, Zuffardi O. Deletion of a 5 cM region at chromosome 8p23 is associated with a spectrum of congenital heart defects. Circulation 102:432-437 (2000).
Tsai C, Graw SL, McGavran L. 8p23 Duplication reconsidered: Is it a true variant with no clinical manifestion? J Med Genet 39:796-774 (2002).
Mullineaux LG, Castellano TM, Shar J, Axell L, Wood ME, Diab S, Klein C, Sitarik M, Deffenbaugh AE, Graw SL. Identification of Germline 185delAG BRCA1 mutations in non-Jewish Americans of Spanish Ancestry from the San Luis Valley, Colorado. Cancer 98:597-602(2003).
Makriyianni IG, Hamel N, Ward S, Foulkes WD, Graw S. BRCA1:185delAG found in the San Luis Valley probably originated in a Jewish founder. J Med Genet 42:e27(2005).
Carniel E, Taylor MRG, Sinagra G, Di Lenarda A, Ku L, Rain, RP, Boucek MM, Cavanaugh J, Miocic S, Slavov D, Graw SL, Feiger J, Zhong X, Dao D, Ferguson DA, Bristow MR, Mestroni L. a-myosin heavy chain. A sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy. Circulation 112:54-59(2005).
Taylor MR, Slavov D, Gajewski A, Vlcek S, Ku L, Fain PR, Carniel E, Di Lenarda A, Sinagra G, Boucek MM, Cavanaugh J, Graw SL, Ruegg P, Feiger J, Zhu X, Ferguson DA, Bristow MR, Gotzmann J, Foisner R, Mestroni L, Familial Cardiomyopathy Registry Research Group. Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy. Hum Mutat 26:566-74(2005).
Carniel E, Taylor MRG, Sinagra G, Di Lenarda A, Ku L, Fain PR, Boucek MM, Cavanaugh J, Miocic S, Slavov D, Graw SL, Feiger J, Zhu XZ, Dao D, Ferguson DA, Bristow MR, Mestroni L. Alpha-myosin heavy chain: a carcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy. Circulation 112:54-59(2005).
Taylor MRG, Slavov D, Ku L, Di Lenarda A, Sinagra G, Carniel E, Haubold K, Boucek M, Ferguson D, Graw SL, Zhu X, Cavanaugh J, Sucharov CC, Long CS, Bristow MR, Lavori, Mestroni L, for the Familial Cardiomyopathy Registry and the BEST (Beta-Blocker Evaluation of Survival Trial) DNA Bank. Prevalance of Desmin mutations in dilated cardiomyopathy. Circulation 115:1244-1251(2007).
Taylor MR, Ku L, Slavov D, Cavanaugh J, Boucek M, Zhu X, Graw S, Carniel E, Barnes C, Quan D, Prall R, Lovell MA, Mierau G, Ruegg P, Mandava N, Bristow MR, Towbin JA, Mestroni L, Familial Cardiomyopathy Registry. Danon disease presenting with dilated cardiomyopathy and a complex phenotype. J. Hum. Genet. 52:830-835(2007)
Grants and Contracts:
NIMH RO1 MH081177-01 (Leonard, P.I.), 7/01/07 to 6/30/12
“Regulation of the Human a7 Nicotinic Receptor Gene in Schizophrenia”
This proposal will study the transcription and translation of the human a7 nicotinic receptor gene in postmortem brain and tissue culture cell lines. Also proposed are genetic studies in the locus of the a7 gene. Role: Examining the influence of CHRFAM7a, a partial duplication of the a7 gene, on a7 transcription, translation, assembly, and function.