Physical Medicine and Rehabilitation

Activities

Current support
Centers for Disease Control (CDC)  (U50/CCU822319-03)
MD Starnet: Survey and tracking of Duchenne and Becker Muscular Dystrophy and other single gene disorders
Role: collaborator
1/1/04-present 

Centers for Disease Control (CDC)
The Colorado Spina Bifida Patient Registry Demonstration Project (1U01DD000385-01)
Role: Co-Investigator
10/1/2008-present

SMA foundation
BforSMA Biomarker study
Role: Co-Investigator
9/1/08-present

Completed Research Support
The Children’s Hospital Research Institute;  Denver, Colorado
Apolipoprotein E: A Major Predictor of Outcome in Pediatric Neurotrauma
Study to determine the role that Apolipoprotein E plays in pediatric traumatic brain and spinal cord injury.
Role: PI
11/1/02- 10/31-05

The Pediatric General Clinical Research Center, The  Children’s Hospital, Denver, Colorado
(NIH, NCRR MO1 RR00069-40; PI:  Richard D. Krugman, Program Director:  Ronald J. Sokol)
Subcontract grant award for:
A Pilot Study to Determine the Influence of the Apolipoprotein E Gene on Outcomes in Pediatric Neurotrauma
Study to determine the role that Apolipoprotein E plays in pediatric traumatic brain and spinal cord injury.
Role: PI
11/1/02-10/31/05

NIH
R01 NF40109-03  PI-Roderic L. Smith
Developmental Epilepsy and Conditional GABA Function
Study focused on the role that chloride homeostasis plays in regulation of GABAA function in the adult and developing nervous system.
Role: Senior Research Scientist/ Co-PI
4/1/2000-3/31/04

Doctorate: University of Colorado Health Sciences Center

Fellowship: Developmental and Molecular Neuroscience Dept. of Pediatric Neurology, Univ. of Colorado Health Sciences Center

Peer reviewed publications:

1.  Wilson PE, Oleszek JL, Clayton GH. Pediatric spinal cord tumors and masses. J Spinal Cord Med 2007;30 Suppl 1:S15-20.

2.  Balaban B, Matthews DJ, Clayton GH, Carry T. Corticosteroid treatment and functional improvement in Duchenne muscular dystrophy: long-term effect. Am J Phys Med Rehabil 2005;84(11):843-50.

3.  Schaack J, Bennett ML, Colbert JD, Torres AV, Clayton GH, Ornelles D et al. E1A and E1B proteins inhibit inflammation induced by adenovirus. Proc Natl Acad Sci U S A 2004;101(9):3124-9.

4.  Lamb FS, Graeff RW, Clayton GH, Smith RL, Schutte BC, McCray PB, Jr. Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium. Am J Respir Cell Mol Biol 2001;24(4):376-81.

5.  Roman RM, Smith RL, Feranchak AP, Clayton GH, Doctor RB, Fitz JG. ClC-2 chloride channels contribute to HTC cell volume homeostasis. Am J Physiol Gastrointest Liver Physiol 2001;280(3):G344-53.

6.  Smith RL, Traul DL, Schaack J, Clayton GH, Staley KJ, Wilcox CL. Characterization of promoter function and cell-type-specific expression from viral vectors in the nervous system. J Virol 2000;74(23):11254-61.

7.  Lamb FS, Clayton GH, Liu BX, Smith RL, Barna TJ, Schutte BC. Expression of CLCN voltage-gated chloride channel genes in human blood vessels. J Mol Cell Cardiol 1999;31(3):657-66.

8.  Moorhead JW, Clayton GH, Smith RL, Schaack J. A replication-incompetent adenovirus vector with the preterminal protein gene deleted efficiently transduces mouse ears. J Virol 1999;73(2):1046-53.

9.  Clayton GH, Staley KJ, Wilcox CL, Owens GC, Smith RL. Developmental expression of C1C-2 in the rat nervous system. Brain Res Dev Brain Res 1998;108(1-2):307-18.

10. Clayton GH, Perez GM, Smith RL, Owens GC. Expression of mRNA for the elav-like neural-specific RNA binding protein, HuD, during nervous system development. Brain Res Dev Brain Res 1998;109(2):271-80.

11. Clayton GH, Owens GC, Wolff JS, Smith RL. Ontogeny of cation-Cl- cotransporter expression in rat neocortex. Brain Res Dev Brain Res 1998;109(2):281-92.

12. Oberhaus SM, Smith RL, Clayton GH, Dermody TS, Tyler KL. Reovirus infection and tissue injury in the mouse central nervous system are associated with apoptosis. J Virol 1997;71(3):2100-6.

13. Smith RL, Clayton GH, Wilcox CL, Escudero KW, Staley KJ. Differential expression of an inwardly rectifying chloride conductance in rat brain neurons: a potential mechanism for cell-specific modulation of postsynaptic inhibition. J Neurosci 1995;15(5 Pt 2):4057-67.

14. Clayton GH, Mahalik TJ, Finger TE. Expression of GAP43 mRNA in normally developing and transplanted neurons from the rat ventral mesencephalon. J Comp Neurol 1994;347(3):470-80.

15. Mahalik TJ, Hahn WE, Clayton GH, Owens GP. Programmed cell death in developing grafts of fetal substantia nigra. Exp Neurol 1994;129(1):27-36.

16. Hudson JL, van Horne CG, Stromberg I, Brock S, Clayton J, Masserano J et al. Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats. Brain Res 1993;626(1-2):167-74.

17. Clayton GH, Mahalik TJ, Finger TE. GAP-43 and 5B4-CAM immunoreactivity during the development of transplanted fetal mesencephalic neurons. Exp Neurol 1991;114(1):1-10.

18. Mahalik TJ, Clayton GH. Specific outgrowth from neurons of ventral mesencephalic grafts to the catecholamine-depleted striatum of adult hosts. Exp Neurol 1991;113(1):18-27.

Book Chapters & Texts:

1.  Amitabh J, Lammertse DP, Charlifue SB, Clayton GH. A Review of Current Clinical Trials for Improving Neurological Outcomes. In: Alexander MS, editor. Issues Related to Performance of Clinical Trials in SCI. Thomas Land Publishers, Inc.; 2006. p 86-100.

2.  Wilson PE, Clayton GH. Health Industry and Product Information. In: Lin VW, editor. Spinal Cord Medicine Principles and Practice. New York: Demos; 2002.

3.   Wilson, PE, Clayton, GH. Sports and Disabilities. In: Moberg-Wolff, E editor. The Seventh Edition: Self-Directed Physiatric Education Program (SDPEP) 2009, AAPM&R Study Guide Focused Review.   IN PRESS 

Dissertations:

Clayton, G.H. (1993) Neuronal responses to lesioning and fetal transplantation within the nigrostriatal system:  A study of neuronal growth related protein expression. Pub. University of Colorado

Abstracts:

1)     Clayton, G.H., Dobyns, E. and Wilson, P.E., Pediatric Risk of Mortality Assessment in Critical Care and Correlation With Functional Outcomes., Archives of PM&R, 2005.

2)     Clayton, G.H., Wilson, P.E., McBride, L., Battan, K., Wathen, J. and Winston, K., Effect of Apolipoprotein E Genotype on Severity of Injury and Functional Recovery in Pediatric Neurotrauma: A Pilot Study. Archives of PM&R, 2005.

3)     Clayton, G.H., Wilson, P.E. and Olezeck, J., The Use of Push Rim Power Assist Wheels in Three Pediatric Patients. JSCM, Vol. 27, 2004, pp. S126.

4)     Wilson, P.E., Apkon, S., Clayton, G.H., Licht, K. and Matthews, D., Evaluation of ANoxic Brain Injuries in Children Using the Coma Near Coma Scale. Arch. PM&R, 2003.

5)     Wilson, P.E., Apkon, S., Clayton, G.H., Licht, K. and Matthews, D., The Utility of the Modified Coma Near Coma Scale in Evaluating Pediatric Brain Injuries. Archives of PM&R, 2003.